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CJC-1295 DAC Peptide: A Scientific Analysis of Its Properties

CJC-1295 DAC (Drug Affinity Complex) is a synthetic peptide analog of growth hormone-releasing hormone (GHRH). It has gained significant attention in the scientific community for its potential. The peptide is primarily studied for its potential to increase the secretion of growth hormone (GH) from the anterior pituitary gland. The structural modifications in CJC-1295 DAC appears to extend its half-life compared to endogenous GHRH, potentially offering prolonged biological activity. This article explores the properties, mechanisms of action, and hypothesized implications of CJC-1295 DAC.

CJC-1295 DAC Peptide: Structure and Mechanism of Action

CJC-1295 DAC comprises 30 amino acids and includes modifications that may support its stability and binding affinity. The addition of the Drug Affinity Complex (DAC) is particularly notable, as it is believed to bind to serum albumin, extending the peptide’s half-life. This modification might allow for less frequent exposure while maintaining sustained GH secretion.

Upon exposure, CJC-1295 DAC is believed to interact with the GHRH receptor on somatotropic cells in the anterior pituitary gland. This interaction is thought to stimulate the release of GH, subsequently influencing the production of insulin-like growth factor 1 (IGF-1) in the liver. IGF-1 is deemed a critical mediator of the growth-promoting impacts of GH, and it might play a part in many physiological processes, including cellular growth, metabolism, and repair mechanisms.

CJC-1295 DAC Peptide: Growth

CJC-1295 DAC is hypothesized to promote growth and development in organisms through its influence on GH and IGF-1 levels. GH is deemed crucial for normal growth and development, especially in skeletal and muscular systems. Research indicates that the peptide might support the multiplication and differentiation of chondrocytes, the cells considered responsible for cartilage formation. This might theoretically lead to increased bone growth and density.

CJC-1295 DAC Peptide: Metabolism

The peptide’s possible influence on GH and IGF-1 suggests potential metabolic regulatory properties. GH is believed to play a role in lipolysis, the breakdown of lipids, which may reduce fatty tissue. Moreover, GH may support protein synthesis and nitrogen retention, which are essential for muscle cell proliferation and tissue repair. Thus, CJC-1295 DAC might be explored for its potential to modulate composition by reducing fat mass and increasing lean muscle mass.

CJC-1295 DAC Peptide: Cell Aging and Longevity

GH levels naturally decline over time, leading to various physiological aging-related changes. It has been hypothesized that CJC-1295 DAC might counteract some of these changes by sustaining GH and IGF-1 levels. This might theoretically contribute to improved vitality and physical function in aging organisms.

The potential anti-aging action that CJC-1295 DAC might extend on a cellular level may also potentially be translatable to the stratum corneum of the skin barrier. GH and IGF-1 are involved in collagen synthesis and skin cell proliferation, processes that decline over time. By maintaining these processes, the peptide might help preserve skin elasticity and thickness.

CJC-1295 DAC Peptide: Muscle Cells

Studies suggest that CJC-1295 DAC might hold promise for supporting muscle function. GH is believed to stimulate the proliferation and differentiation of myoblasts, the precursor cells to muscle tissue. Additionally, it may support muscle protein synthesis, contributing to muscle hypertrophy and contractile force. The peptide’s potential to increase IGF-1 levels is also significant, as IGF-1 plays an apparently critical role in muscle repair and regeneration.

CJC-1295 DAC Peptide: Bone Density

Bone density and strength are closely linked to GH and IGF-1 levels. These hormones stimulate the activity of osteoblasts, the cells responsible for bone formation. CJC-1295 DAC might thus be considered for its potential to support bone mineral density and reduce the risk of fractures, particularly in cases of osteoporosis.

CJC-1295 DAC Peptide: Cognitive Research

Emerging research suggests that GH and IGF-1 might play cognitive function and neuroprotection roles. GH receptors are present in many brain areas, like the hippocampus, which is implicated in learning and memory. It has been hypothesized that CJC-1295 DAC might influence cognitive processes through its impacts on GH and IGF-1. IGF-1, in particular, is thought to promote neurogenesis and protect against neurodegenerative processes. While the precise mechanisms remain fully elucidated, the peptide might offer intriguing cognitive support and neuroprotection potential.

CJC-1295 DAC Peptide: Immunity

Research indicates that the immune system is another area where CJC-1295 DAC might exert influence. GH and IGF-1 are believed to affect immune cell proliferation and function. GH may modulate the activity of T-cells, B-cells, and macrophages, deemed critical immune response components. By sustaining GH levels, CJC-1295 DAC is hypothesized to support immune surveillance and response, potentially improving the organism’s ability to combat infections and diseases.

CJC-1295 DAC Peptide: Conclusion

CJC-1295 DAC for sale represents a promising peptide with various implications based on its potential to stimulate GH and IGF-1 secretion. The DAC modification’s extended half-life might make it a valuable tool for sustained biological impacts. The peptide’s properties suggest potential roles in promoting growth, regulating metabolism, supporting muscle cell development and bone function, and possibly enhancing cognitive and immune functions. However, further research is necessary to fully understand the mechanisms and validate the hypothesized implications of CJC-1295 DAC in various physiological processes.

References

[i] N. J. Lemme, N. Y. Li, S. F. DeFroda, J. Kleiner, and B. D. Owens, “Epidemiology of Achilles Tendon Ruptures in the United States: Athletic and Nonathletic Injuries From 2012 to 2016,” Orthop. J. Sports Med., vol. 6, no. 11, p. 2325967118808238, Nov. 2018, doi: 10.1177/2325967118808238.

[ii] M. Ionescu and L. A. Frohman, “Pulsatile secretion of growth hormone (GH) persists during continuous stimulation by CJC-1295, a long-acting GH-releasing hormone analog,” J. Clin. Endocrinol. Metab., vol. 91, no. 12, Art. no. 12, Dec. 2006, doi: 10.1210/jc.2006-1702.

[iii] M. Alba et al., “Once-daily administration of CJC-1295, a long-acting growth hormone-releasing hormone (GHRH) analog, normalizes growth in the GHRH knockout mouse,” Am. J. Physiol. Endocrinol. Metab., vol. 291, no. 6, pp. E1290-1294, Dec. 2006, doi: 10.1152/ajpendo.00201.2006.

[iv] S. L. Teichman, A. Neale, B. Lawrence, C. Gagnon, J.-P. Castaigne, and L. A. Frohman, “Prolonged stimulation of growth hormone (GH) and insulin-like growth factor I secretion by CJC-1295, a long-acting analog of GH-releasing hormone, in functiony adults,” J. Clin. Endocrinol. Metab., vol. 91, no. 3, pp. 799–805, Mar. 2006, doi: 10.1210/jc.2005-1536.

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Features

Gambling Statistics Shine Light on Canadian Gambling Culture

Explore pivotal statistics that highlight Canada’s gambling culture. Get a concise overview of the trends shaping the nation’s betting landscape.

Canada’s gambling culture is as diverse as its landscape, and recent statistics shed light on this thriving sector. From coast to coast, Canadians engage in various forms of betting, each with its own set of trends and numbers. This article delves into the data, uncovering the patterns and preferences defining gambling nationwide.

Canadian Gambling Statistics

User penetration refers to the percentage of consumers engaging with a product or service beyond the expected audience. Despite a 47% decline in 2023, the online gambling industry is projected to expand.

By 2027, it’s forecasted that the gambling market will cater to 20.38 million individuals. This trend suggests an increasing preference among Canadians for online gambling over traditional brick-and-mortar casinos.

The industry boasted a 97% return on investment in 2022, outperforming land-based casinos, which only saw a 61% return. With the rising interest in online betting, Canada’s online casino industry is experiencing the highest user penetration rate.

What Is the Average Expenditure on Gambling by Canadians?

Many enjoy the thrill of the occasional game of chance. The fact that you can retain all of your earnings, as there are no taxes on gambling profits in Canada, adds to the allure of gambling. In Canada, winnings are subject to taxation only for professional gamblers with a sustained winning streak.

In recent years, the trend toward online casinos has changed. The pandemic-induced closures of land-based casinos accelerated this change. It’s a profitable industry, as 60% of Canadians say they spend money gambling each month.

Canadian gambling statistics:

  • Six out of ten Canadians have gambled.
  • The monthly average expenditure for gaming and gambling in Canada is $6.75.
  • A month’s worth of gaming expenses is reported by 63% of males and 57% of women.
  • According to 73% of Canadians, gambling-related issues have gotten worse in their region.

The Increasing Attraction to Online Casino Gambling in Canada

An increasing number of Canadians are using online casinos, particularly in the wake of the pandemic. They offer various benefits regular casinos do not and are more convenient. Over time, land-based casinos’ revenue has decreased due to the growing popularity of online gambling sites.

The pandemic shutdowns accelerated the drop. For instance, the land-based casinos in Alberta no longer make as much money as they once did. Consequently, the Albertan government opened an online casino, and other governments quickly adopted similar strategies.

Casino Games at Online Casinos in Canada

Online casinos in Canada offer various games that cater to different preferences. Some of the most popular casino games at Canadian online casinos include:

  • Slots: These are the most common and varied, with themes ranging from classic fruit machines to the latest online slot games with advanced graphics and features.
  • Table Games: Classics like blackjack, roulette, craps, and baccarat are available in multiple variations.
  • Live Dealer Games: These provide an immersive experience, allowing players to interact with real dealers and other players in real time.
  • Video Poker: A favourite for many, combining elements of slots and poker in a unique format.
  • Progressive Jackpots: Games that offer the chance to win life-changing sums of money with a single spin.
  • Canadian Legalities for Online Gambling Sites
  • Casinos are legal in Canada, but each province and territory has the authority to establish its gaming regulations and issue online gambling website licences. Saskatchewan is the only province that does not host multiple online gaming sites.
  • Authorities in British Columbia, Ontario, Quebec, and Manitoba issue licences without a specific requirement, but these online casinos must operate exclusively within their respective provincial borders. Online gaming sites seeking to operate beyond these borders need a special agreement.
  • In Canada, only land-based casinos face penalties; foreign operators can only function by obtaining local licenses. Although offshore casinos cannot legally target Canadian players, they can accept them.
  • Statistics on Gambling Addiction in Canada
  • While the majority of gamblers do so without experiencing issues, there are hazards and health issues associated with it for some people. Because of this, the Canadian Centre on Substance Use and Addiction (CCSA) carries out studies and creates resources aimed at assisting Canadians in making wise decisions regarding their gambling, both generally and, in particular, high-risk scenarios, like when they’re using alcohol or other drugs.
  • Here are some key statistics on gambling addiction in Canada for the year 2024:
  • 64.5% of Canadians aged 15 or older actively participated in gambling activities within the past year.
  • 1.6% of Canadian gamblers, representing approximately 304,400 individuals, face moderate-to-severe gambling addiction risks.
  • Canadian males reported higher gambling participation and addiction risks compared to females.
  • Indigenous Canadians showed a higher tendency to gamble (72.4%) and experienced greater susceptibility to gambling problems (4.5%) than non-Indigenous people.
  • In Canada, responsible gambling is promoted through various programs and initiatives, ensuring that individuals engage in betting activities within their means and maintain control. The emphasis is on providing resources and support to prevent gambling addiction and encourage safe, enjoyable gaming experiences.
  • Reflecting on Canada’s Responsible Gambling Journey
  • The statistics we’ve explored offer a revealing glimpse into Canada’s gambling culture, highlighting both the widespread appeal and the responsible practices of Canadian bettors. As the industry evolves, it reflects the country’s commitment to balancing entertainment with economic benefit and social responsibility. The future of gambling in Canada seems poised to be driven by informed choices and a clear understanding of the risks and rewards involved.
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Features

Caesars Windsor Reduces Operating Hours for Sports Betting Counter

Sports betting has rapidly evolved into a major attraction, drawing a diverse audience ranging from casual participants to dedicated enthusiasts, and its popularity is only increasing with the proliferation of online platforms. In particular, Canada has seen a notable rise in sports betting activities since the legalization of single-event sports betting in August 2021, which opened doors to a multitude of betting avenues, both in physical locations and online. 

The shift towards online sportsbooks has been especially significant, marking a notable change in the landscape of sports betting. Given the expansive range of online sportsbooks available to Canadians, experts like Neil Roarty provide critical reviews and comparisons that guide bettors through the complex array of online options. These sites delve into the nuances of each platform, evaluating everything from user interface and betting options to the perks and security features they offer (source: bestsportsbettingcanada.ca/).  

Despite the rising trend in online betting, traditional sportsbooks like those in casinos are adjusting to the new landscape. Caesars Windsor, for instance, has recently made significant changes to its sports betting services. Initially projected to increase job opportunities and enhance visitor footfall, thereby boosting various service-related positions within the casino, the reality has somewhat shifted. 

The casino’s CEO, Kevin Laforet, had expressed optimism at the sportsbook’s inauguration in January 2023, citing anticipated growth in employment opportunities due to expected higher traffic. This optimism was rooted in the broader economic benefits typically associated with casino expansions, such as increased employment for local and migrant communities including roles like dealers, bartenders, and security staff.

However, recent developments have seen Caesars Windsor recalibrating its approach to sports betting. According to a spokesperson from the casino, after a detailed review of betting trends at their facility, adjustments were necessary to align the sportsbook’s operations with actual guest preferences and patterns. 

As a result, the sportsbook has scaled back its operating hours to 3 p.m. to 11 p.m. each day, which has led to minor staffing changes. Importantly, all affected staff members have been retained, and the sportsbook continues to operate during peak times, especially during significant sporting events, with kiosk betting available 24/7.

Jessica Welman, editor of the Canadian Gaming Business, remarks on the overwhelming preference for online sports gambling over traditional brick-and-mortar sportsbooks. The convenience of placing bets via a smartphone or computer is a significant draw for many, enhancing the accessibility and appeal of online betting. 

Welman further noted that the market for online betting in Ontario has expanded consistently each quarter since its legalization, highlighting a robust growth trajectory that underscores the market’s potential.

However, the relationship between online gambling and its impact on physical casino revenues is complex and not well-documented. Sports betting reporter Greg Warren pointed out that most casinos do not specifically track how much of their revenue comes from sports betting as opposed to other gambling activities, which muddles the ability to analyze precise trends. 

Yet, experiences from the United States suggest that both in-person and online sportsbooks can experience growth simultaneously, indicating a synergistic relationship rather than a competitive one. According to Warren, the distinct experiences offered by online platforms and physical sportsbooks mean they can coexist and cater to different preferences.

Welman supports this view, suggesting that despite the convenience of online options, there is an enduring appeal for the physical experience of in-person betting. She argues that brick-and-mortar casinos provide a unique atmosphere that can’t be replicated online, serving as a draw for those who prefer the tangible excitement of a live betting environment. 

In line with its diverse offerings, Caesars Entertainment also maintains an online gaming app, which complements its physical sportsbook operations. This app is designed to offer users a seamless integration between the convenience of digital betting and the engaging atmosphere of in-person wagering. 

While specific details on the app’s impact on the casino’s overall business were not disclosed, it represents an integral part of Caesars’ strategy to bridge the gap between traditional and digital gambling experiences. This dual approach not only caters to a broader range of consumer preferences but also positions Caesars to capitalize on the growing trend of mobile and online betting.

As the landscape of sports betting continues to evolve, the interaction between online and in-person gambling platforms will undoubtedly remain a key area of focus for industry observers and participants alike. By maintaining a strong presence in both arenas, Caesars is well-equipped to adapt to changing consumer habits and technological advancements that have seen real money online casinos cornering many gambling markets worldwide, ensuring that it remains at the forefront of the gambling industry. 

This strategic integration highlights the potential for more synchronized growth and innovation within the gambling sector, shaping the future of how sports betting is experienced across different platforms.

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Features

“Ain’t No Grave” – new novel set in Deep South in early 20th century combines interracial love story with searing description of the Leo Frank trial and lynching

Book cover/author Mary Glickman

Reviewed by BERNIE BELLAN In 1975, American novelist E. L. Doctorow made waves with “Ragtime,” a novel that interspersed true historical American figures from the first part of the 20th century with fictitious characters. The novel explored the overt racism faced by Blacks in America at that time, along with the antisemitism that was also prevalent.
Now, with a new novel by Mary Glickman, who has specialized in writing historical fiction centering around Jewish characters in the Deep South of the U.S., the themes of anti-Black and antisemitic prejudice in the South reach a traumatic apex, culminating with the lynching of New York-born Leo Frank in Georgia, in 1915.
But – since I don’t like to read too much about what a novel is about before I delve into it, I really didn’t know to what extent the Leo Frank case was going to play a role in this particular book. I prefer to be surprised. Unfortunately, if you’re also of a similar mind, I’m afraid I’ve already let the cat out of the bag.
The story opens, however, not in Atlanta, which is where Leo Frank was framed for the murder of 13-year-old Mary Phagan, but in a part of backwoods Georgia known as Heard County, where we meet the two central characters of the book: Young Max Sassaport, the son of the only Jewish couple in his small rural village, and Max’s best friend, an equally young Ruby Johnson, the Black daughter of a sharecropper.
The two children – though from totally dissimilar backgrounds, share a deep bond – which they keep hidden from all around them. Glickman’s lilting prose and her depiction of rural Georgia life reminded me of another wonderful novel, also set in the Deep South: “Where the Crawdads Sing.”
Of course, a relationship between a Black girl and a White boy (and a Jew no less) is bound to come asunder – and even as youngsters, Ruby and Max are aware that they are fated to be split apart. Yet, with the introduction of a fascinating character known as Mayhayley Lancaster, who is described as a “witch,” but who later turns out to be a real person who actually played somewhat of a role in the Leo Frank trial, the children’s fate is foretold. (Again, I don’t want to give too much of the story away, but Mayhayley Lancaster’s transformation later in the novel turned out to be one of the biggest surprises of the book.)
As the first part of the story develops – and it becomes apparent that Ruby and Max are destined to take different roads in their lives, one of the interesting aspects of the story for Jewish readers will be what life would have been like for the only Jewish family in a small Southern town. The Sassaports operate a general dry goods store – as did many Jews in rural locations throughout the U.S. and Canada, but their connection to Judaism is tenuous at best.
In time, both Max and Ruby make their way to Atlanta, but with Ruby leaving when she is only 12 years old and Max waiting another six years before he ends up in Atlanta, neither one of them holds much hope that they will ever see each other again.
Max, however, meets up with a reporter for the Atlanta Journal known as Harold Ross (who would later go on, in real life, to found The New Yorker). Ross takes Max under his wing as a cub reporter and it’s in Max’s capacity as a reporter that he finds himself enmeshed in the Leo Frank trial.
As a press release for the novel explains: “1913. The year heart-sick Max travels to Atlanta to find Ruby, his lost love and childhood friend. And the year New York Jew, Leo Frank, is charged with the murder of a child laborer at the National Pencil Factory. Max is Jewish and Ruby’s Black. Their reunion takes place just as Frank is arrested, a racially charged event that sparks an explosion of antisemitism across the city of Atlanta.”
Although I had somewhat of a recollection of reading about the Leo Frank trial, reading about the events surrounding that trial and its aftermath comes as somewhat of a shock. Leo Frank was framed for the murder of a 13-year-old White girl but the degree to which the police and the prosecutor were determined to pursue a totally made-up case against an innocent Jewish businessman is still jarring to read. As well, when one contemplates how comfortable Donald Trump is with telling one lie after another to suit his agenda, it becomes much easier to understand how so many White authority figures in “Ain’t No Grave” were willing to engage in a total frame-up so as to enrage their White base. The role that many newspapers at the time played in stoking antisemitism also provides a salutary experience in how easy it has always been to dupe a huge proportion of the American public though fictitious media reporting. In 1915 it was through newspapers; today, it’s through the internet.
As the book’s press release notes the parallels between what was happening in the early years of the 20th century and what we are seeing playing out around the world today, “With global antisemitism on the rise, “Ain’t No Grave” draws attention to the fact that garden variety antisemitism can be stoked by bad actors and quickly explode into violence. Sometimes, the media play a role.”
The Jewish community of Atlanta in 1915 was so terrified by what was happening to Leo Frank that events at the time led to the creation of B’nai Brith’s Anti-Defamation League.
The juxtaposition of vicious antisemitism and anti-Black hatred in the Deep South with a love story between a White Jew and a Black woman makes for a compelling read. As a member of the Southeast ADL by the name of Sandra Brett noted after reading “Ain’t No Grave,” “Mary Glickman vividly captures milestones in the Leo Frank saga through sympathetic characters as real as the events surrounding them. She deftly intertwines Leo Frank’s trial and lynching with the founding of the ADL, the rebirth of a moribund KKK, and an interracial love story. Meticulously researched, fast-paced, and thoroughly original, Ain’t No Grave is a moving, satisfying read.”
And, as Pat Conroy, author of another best selling novel set in the Deep South – “Prince of Tides”, wrote about Mary Glickman: “Mary Glickman is a wonder.”

Buy this book on Amazon

Ain’t No Grave
By Mary Glickman
280 Pages,
Publication Date: July 2024
Open Road Integrated Media, Inc.


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