Features
CJC-1295 DAC Peptide: A Scientific Analysis of Its Properties

CJC-1295 DAC (Drug Affinity Complex) is a synthetic peptide analog of growth hormone-releasing hormone (GHRH). It has gained significant attention in the scientific community for its potential. The peptide is primarily studied for its potential to increase the secretion of growth hormone (GH) from the anterior pituitary gland. The structural modifications in CJC-1295 DAC appears to extend its half-life compared to endogenous GHRH, potentially offering prolonged biological activity. This article explores the properties, mechanisms of action, and hypothesized implications of CJC-1295 DAC.
CJC-1295 DAC Peptide: Structure and Mechanism of Action
CJC-1295 DAC comprises 30 amino acids and includes modifications that may support its stability and binding affinity. The addition of the Drug Affinity Complex (DAC) is particularly notable, as it is believed to bind to serum albumin, extending the peptide’s half-life. This modification might allow for less frequent exposure while maintaining sustained GH secretion.
Upon exposure, CJC-1295 DAC is believed to interact with the GHRH receptor on somatotropic cells in the anterior pituitary gland. This interaction is thought to stimulate the release of GH, subsequently influencing the production of insulin-like growth factor 1 (IGF-1) in the liver. IGF-1 is deemed a critical mediator of the growth-promoting impacts of GH, and it might play a part in many physiological processes, including cellular growth, metabolism, and repair mechanisms.
CJC-1295 DAC Peptide: Growth
CJC-1295 DAC is hypothesized to promote growth and development in organisms through its influence on GH and IGF-1 levels. GH is deemed crucial for normal growth and development, especially in skeletal and muscular systems. Research indicates that the peptide might support the multiplication and differentiation of chondrocytes, the cells considered responsible for cartilage formation. This might theoretically lead to increased bone growth and density.
CJC-1295 DAC Peptide: Metabolism
The peptide’s possible influence on GH and IGF-1 suggests potential metabolic regulatory properties. GH is believed to play a role in lipolysis, the breakdown of lipids, which may reduce fatty tissue. Moreover, GH may support protein synthesis and nitrogen retention, which are essential for muscle cell proliferation and tissue repair. Thus, CJC-1295 DAC might be explored for its potential to modulate composition by reducing fat mass and increasing lean muscle mass.
CJC-1295 DAC Peptide: Cell Aging and Longevity
GH levels naturally decline over time, leading to various physiological aging-related changes. It has been hypothesized that CJC-1295 DAC might counteract some of these changes by sustaining GH and IGF-1 levels. This might theoretically contribute to improved vitality and physical function in aging organisms.
The potential anti-aging action that CJC-1295 DAC might extend on a cellular level may also potentially be translatable to the stratum corneum of the skin barrier. GH and IGF-1 are involved in collagen synthesis and skin cell proliferation, processes that decline over time. By maintaining these processes, the peptide might help preserve skin elasticity and thickness.
CJC-1295 DAC Peptide: Muscle Cells
Studies suggest that CJC-1295 DAC might hold promise for supporting muscle function. GH is believed to stimulate the proliferation and differentiation of myoblasts, the precursor cells to muscle tissue. Additionally, it may support muscle protein synthesis, contributing to muscle hypertrophy and contractile force. The peptide’s potential to increase IGF-1 levels is also significant, as IGF-1 plays an apparently critical role in muscle repair and regeneration.
CJC-1295 DAC Peptide: Bone Density
Bone density and strength are closely linked to GH and IGF-1 levels. These hormones stimulate the activity of osteoblasts, the cells responsible for bone formation. CJC-1295 DAC might thus be considered for its potential to support bone mineral density and reduce the risk of fractures, particularly in cases of osteoporosis.
CJC-1295 DAC Peptide: Cognitive Research
Emerging research suggests that GH and IGF-1 might play cognitive function and neuroprotection roles. GH receptors are present in many brain areas, like the hippocampus, which is implicated in learning and memory. It has been hypothesized that CJC-1295 DAC might influence cognitive processes through its impacts on GH and IGF-1. IGF-1, in particular, is thought to promote neurogenesis and protect against neurodegenerative processes. While the precise mechanisms remain fully elucidated, the peptide might offer intriguing cognitive support and neuroprotection potential.
CJC-1295 DAC Peptide: Immunity
Research indicates that the immune system is another area where CJC-1295 DAC might exert influence. GH and IGF-1 are believed to affect immune cell proliferation and function. GH may modulate the activity of T-cells, B-cells, and macrophages, deemed critical immune response components. By sustaining GH levels, CJC-1295 DAC is hypothesized to support immune surveillance and response, potentially improving the organism’s ability to combat infections and diseases.
CJC-1295 DAC Peptide: Conclusion
CJC-1295 DAC for sale represents a promising peptide with various implications based on its potential to stimulate GH and IGF-1 secretion. The DAC modification’s extended half-life might make it a valuable tool for sustained biological impacts. The peptide’s properties suggest potential roles in promoting growth, regulating metabolism, supporting muscle cell development and bone function, and possibly enhancing cognitive and immune functions. However, further research is necessary to fully understand the mechanisms and validate the hypothesized implications of CJC-1295 DAC in various physiological processes.
References
[i] N. J. Lemme, N. Y. Li, S. F. DeFroda, J. Kleiner, and B. D. Owens, “Epidemiology of Achilles Tendon Ruptures in the United States: Athletic and Nonathletic Injuries From 2012 to 2016,” Orthop. J. Sports Med., vol. 6, no. 11, p. 2325967118808238, Nov. 2018, doi: 10.1177/2325967118808238.
[ii] M. Ionescu and L. A. Frohman, “Pulsatile secretion of growth hormone (GH) persists during continuous stimulation by CJC-1295, a long-acting GH-releasing hormone analog,” J. Clin. Endocrinol. Metab., vol. 91, no. 12, Art. no. 12, Dec. 2006, doi: 10.1210/jc.2006-1702.
[iii] M. Alba et al., “Once-daily administration of CJC-1295, a long-acting growth hormone-releasing hormone (GHRH) analog, normalizes growth in the GHRH knockout mouse,” Am. J. Physiol. Endocrinol. Metab., vol. 291, no. 6, pp. E1290-1294, Dec. 2006, doi: 10.1152/ajpendo.00201.2006.
[iv] S. L. Teichman, A. Neale, B. Lawrence, C. Gagnon, J.-P. Castaigne, and L. A. Frohman, “Prolonged stimulation of growth hormone (GH) and insulin-like growth factor I secretion by CJC-1295, a long-acting analog of GH-releasing hormone, in functiony adults,” J. Clin. Endocrinol. Metab., vol. 91, no. 3, pp. 799–805, Mar. 2006, doi: 10.1210/jc.2005-1536.
Features
Winnipeg Beach Synagogue about to celebrate 75th anniversary

By BERNIE BELLAN (July 13) In 1950 a group of cottage owners at Winnipeg Beach took it upon themselves to relocate a one-room schoolhouse that was in the Beausejour area to Winnipeg Beach where it became the beach synagogue at the corner of Hazel and Grove.
There it stayed until 1998 when it was moved to its current location at Camp Massad.
On August 2nd members of the synagogue will be holding a 75th anniversary celebration.

As part of the celebration anyone who is a descendant or relative of any of the original members of the first executive committee (as seen in the photo here) is invited to attend the synagogue that morning.
If you are a relative please contact Abe Borzykowski at wpgbeachshule@shaw.ca or aborzykowski@shaw.ca to let Abe know you might be attending or for more information about the 75th anniversary celebration.
We will soon be publishing a story about the history of the beach synagogue, which is something I’ve been writing about for over 25 years.
Features
Kinzey Posen: CBC Winnipeg’s former “go-to guy”

By GERRY POSNER If former Winnipegger Lawrence Wall was the CBC go-to guy in Ottawa, CBC Winnipeg had its own version of a go-to guy for many years with none other than the very well known Kinzey Posen. Of course, many readers will recognize that name from his career with Finjan, the Klezmer group so famous across Canada and beyond. It has been written about Posen and his wife Shayla Fink that they have been involved in music since they got out of diapers. And, as an aside, their love and ability in music has now been transmitted to the next generation as in their son, Ariel Posen (but that’s another story).
Kinzey Posen (not to be confused with Posner, or maybe we are to be confused, but who knows for sure?), was a graduate of Peretz School, having attended there from nursery right until Grade 7, graduating in1966. That was followed by Edmund Partridge and West Kildonan Collegiate. Musically, he was in large part self taught. However, he did have some teachers along the way. After moving to Vancouver – from 1974-78, he had the chance to study acoustic classical bass with a member of the Vancouver Symphony Orchestra. When Kinzey lived in Vancouver, he also worked as a jazz musician.
Upon returning to Winnipeg, Kinzey enrolled as a mature student at the University of Winnipeg, where he obtained a Bachelor of Urban Studies degree. Although the degree was in no way connected to the career that followed, his attending the University of Winnipeg was critical to his connecting with the CBC. Why? you ask. Kinzey had a position after graduation working for the Institute of Urban Studies. While there, he met someone who invited him to work for the Department of Continuing Education as one of their program directors. At the time the Department of Continuing Education was located at 491 Portage Avenue, which was also known as the TJ Rice Building. The CBC also leased some space in the same building. According to Kinzey, the CBC part of the building “included HR, different shows and other support offices. Continuing Education was located in the basement and main floor and that’s where I worked.”
KInzey had long had an interest in the CBC, which made the fact that the CBC had some offices in the same building where he was working serendipitous. That Kinzey might be interested in visiting the CBC was not an accident. As a young boy he had a nightly connection to CBC, as it was his ritual to listen to CBC Radio (as well as all sorts of other radio stations across the USA) on his transistor radio every night in bed. He became enamoured of one particular CBC host, Bill Guest, so that when going to sleep, he imagined that he was Guest doing interviews with imaginary guests. That dream of working for CBC became a reality when he had a chance to do a one week gig with Jack Farr’s network program.
Kinzey took a week off from his Continuing Education job and spent five days at the CBC. That week was a training session for Posen, as he had to create ideas, research, pre-interview, write the script, and set up the studio for Farr’s interview. He was almost in his dream job – although not quite – since it was only for one week. His opportunity, however, came in 1988, when he was offered a one-year term as a production assistant – the lowest guy on the ladder, for a show called “ Simply Folk,” with the late Mitch Podolak as the host. Although he was indeed at the bottom as far as those working on the show were concerned, he took a chance and gave his notice to the U of W. The rest is history. In his new job, Kinzey learned how to become a producer. Lucky for him, at the end of the year, when the person he replaced was supposed to come back, she never returned (just like the song, “MTA,” by the Kingston Trio). At that point, Kinzey was hired full time at the CBC.
Kinzey was a fixture at the CBC for 27 years. During those years, Kinzey had the chance to work with Ross Porter, a respected former CBC host and producer, also with Karen Sanders – on the “Afternoon Edition.” One aspect of Kinzey’s job on the Afternoon Edition was to come up with ideas, mix sound effects, arrange interviews and music, to create a two-hour radio experience. In addition, he covered jazz and folk festivals and, as a result, was exposed to some of the best musicians in the world. With Ross Porter in the 1990s, he worked on a network jazz show called “ After Hours,” which was on from 8-10 PM five nights a week. Kinzey was involved with writing the scripts, picking the music, and recording the shows, as well as editing them and then presenting them to the network for playback.
Of course, over his career, Kinzey had many memorable moments. He told me about one of them. The story revolved around the National Jazz Awards one year in particular. The awards were to be broadcasted after the National News which, in those days, began much earlier in the evening, and were over by 8:00 pm. The legendary Oscar Peterson was lined up to play a half hour set at the awards, starting at 7:30. But, as Kinzey told me, Oscar Peterson had a “hate on” for the CBC ecause one of his recorded performances was wrongly edited and he refused to appear on CBC under any circumstances. As the time neared 8:05 PM, which was when the CBC was to begin its broadcast of the jazz awards, it became apparent that Oscar was not going to finish on time. As the producer of the awards show, Kinzey was tasked with telling Oscar Peterson to wrap it up and get off the stage. There was Kinzey Posen, a huge fan of Oscar Peterson, now faced with the prospect of telling Oscar – while he was still playing – with 500 people in the audience, to stop and get off the stage. Not often was or is Kinzey Posen frozen, but that was one such moment. There was one loud “Baruch Hashem” from Kinzey when Oscar completed his set literally just in time.
Clearly, Kinzey was part of a very successful run with After Hours as it was on the air for 14 years. It was easily one of the most popular shows on CBC Radio 2, and a winner of several broadcasting awards. Kinzey also played a major role in producing a two part documentary about legendary guitarist Lenny Breau.
When After Hours ended, Posen became one of the contributing producers to Canada Live and specialized in producing live radio specials for the network, such as the Junos, for CBC Radio One and Two. Needless to say, his career planted Posen in the world of some top notch musicians, including his time spent working with Robert Plant (Led Zeppelin), Dave Brubeck, Randy Bachman, Chantal Kreviazuk and a list of prominent names in the Canadian, American and European music spheres. Locally, the CBC came to refer to Kinzey as the Jewish expert. I would add music expert to that title.
After his 27 year run at the CBC – and before he fully retired, Kinzey went on to work for the Rady JCC as a program director for a year and a half. Of course, to say that Kinzey Posen is retired is a major contradiction in terms. You really can’t keep him down and he has his hand in a variety of programs and projects – most of which he remains silent about, as is his style.
When I realized the full depth and talent of Kinzey Posen, I quickly concluded that he must certainly be related to me. Even if he isn’t, I now tell people he is.
Features
History of a Holocaust Survivor Turning Eighty

By HENRY SREBRNIK On July 19, I turn 80 years old. This is indeed a milestone, but for me, an even bigger one was just being born. My parents were Holocaust survivors, and I found out just a few months ago that, technically, so am I. My parents were from Czestochowa, Poland, where I was born in 1945. By 1943 most Jews in the city, including their own families, had been murdered by the Nazis, at Treblinka, and after the uprising in the Jewish ghetto, my parents, by now married, became slave labour in a major Nazi munitions plant, the HASAG-Pelcery concentration camp, in the city.
The Russian army liberated Czestochowa January 16-17, 1945, and I was born July 19, six months later. You can do the math. My mother was emaciated and didn’t even know she was pregnant, but another month, and it would have been obvious, and she would have been killed. (I never asked how this happened but found out when listening to her testimony for the Shoah Foundation in 1995. The men and women were housed in different barracks, but one night the Germans were delousing one of the buildings and allowed married couples to sleep together in the other.)

In 1945 the 9th of Av fell on July 19, and the Jewish world had just gone through our worst period in history. I was born in a makeshift hospital at the Jasna Gora, the famed Pauline Catholic monastery in the city. The actual city hospital had been destroyed in the fighting. It is home to the Matka Boska Czestochowska, (“the mother of God”), a very beautiful and large icon of Mary and the baby Jesus. Other women giving birth were surprised and one said, “Ona jest Zydowka” (She’s a Jew). So, though I am a proud Polish Jew, this could only have helped! The doctor who delivered whispered to my mother that he was Jewish but added that he wanted it kept quiet because he wasn’t going to leave Poland. It also took awhile for a mohel to come to the city for me.
The next few years were spent in Pocking-Waldstadt, a DP camp in the American zone in Bavaria, Germany, and then on to Pier 21 in Halifax and Canada. We lived in Montreal, though at home we were to all intents and purposes in Czestochowa, Jewish Poland.
As I was packing up my books in May because we all had to vacate our offices for the summer due to repairs in our building, I came across a book that I had never read – I don’t even recall where I got it — by the Polish historian Lucjan Dobroszycki, Survivors of the Holocaust in Poland: A Portrait Based on Jewish Community Records 1944-1947 (Armonk, New York: M.E. Sharpe, 1994). Chapter 5 is comprised of “Lists of Jewish Children Who Survived,” in alphabetical order. I am listed on p. 146 (Heniek Srebrnik, 1945). I sent in a form to the Claims Conference in New York informing them. So, at age 80, I’ve become a Holocaust survivor! Compared to that start, the next decades have been easy street! As the Aussies say, “no worries! But the Jewish world has grown darker. Like many others, were I to write a memoir, I’d call it From Hitler to Hamas.
I grew up in Montreal, and have lived in Calgary and Charlottetown, as well as London, England, and four American cities. But I’ve only been to Winnipeg twice, in 1982 and, more dramatically, the weekend of Sept. 7-10, 2001. I presented a paper on “Birobidzhan on the Prairies: Two Decades of Pro-Soviet Jewish Movements in Winnipeg,” to a conference on “Jewish Radicalism in Winnipeg, 1905-1960,” organized by the Jewish Heritage Centre of Western Canada. I left the morning of Sept. 11. An hour into the flight to Toronto we were told all airplanes had to land at the nearest major airport. I spent the next three days in Sault Ste. Marie, Ont., with fellow passengers. We mostly watched the television reporting on the 9/11 catastrophe.
Though an academic, I have always written for newspapers, including Jewish ones, in Canada and the United States. Some, like the Jewish Free Press of Calgary, the Jewish Tribune of Toronto, and the previous version of the Canadian Jewish News, no longer exist, which is a shame. Fortunately, the Jewish Post still does.
Henry Srebrnik is a professor of political science at the University of Prince Edward Island.