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Raphael Mechoulam, Israel’s ‘father of cannabis research,’ dies at 92
(JTA) — In the early 1960s, a Bulgarian-born scientist named Raphael Mechoulam was caught carrying five kilograms of, as he called it, “superb, smuggled Lebanese hashish” on a bus from Tel Aviv to Rehovot. But he wasn’t planning on smoking the stuff.
Mechoulam was a fledgling researcher keen on exploring the science behind cannabis, a stigmatized plant whose specific medical properties were not yet known. Over the decades he became a pioneer in cannabis research, whose findings about the psychoactive substance helped ease its entry out of the counterculture and into the mainstream.
Mechoulam died in Israel at age 92; his death was announced Friday by American Friends of the Hebrew University, where Mechoulam helped form The Hebrew University Multidisciplinary Center for Cannabinoid Research in 2017.
“Most of the human and scientific knowledge about cannabis was accumulated thanks to Prof. Mechoulam,” Hebrew University President Asher Cohen said in a statement. “He paved the way for groundbreaking studies and initiated scientific cooperation between researchers around the world. Mechoulam was a sharp-minded and charismatic pioneer.”
As a professor in the Hebrew University School of Pharmacy, Mechoulam and his research team isolated THC, the psychoactive component of cannabis, as well as cannabidiol, or CBD, an active ingredient in cannabis with a range of medicinal benefits.
He also pioneered the study of the body’s own cannabinoid system, which produces chemicals similar to THC to help regulate appetite, manage pain and operate the immune system.
As Mechoulam discovered more about cannabis and its efficacy in easing symptoms of cancer, epilepsy and other diseases, he lamented that strict drug laws in the United States and elsewhere suppressed research and kept the derivatives of cannabis off the market.
“Medicinal cannabis has to follow medical lines of thought and development and modern medical routes” in order to be part of proper drugs, he told the New York Times in 2017. “Israel has more [clinical trials] than the United States at the moment, which is ridiculous.”
Mechoulam was a founding member of the International Association for Cannabinoid Medicines and the International Cannabinoid Research Society. In 1994, he was elected to be a member of the Israel Academy of Sciences and Humanities.
Mechoulam was born in Bulgaria in 1930 and immigrated in 1949 with his family to Israel, where he later studied chemistry. He received his PhD at the Weizmann Institute in Rehovot, writing a thesis on the chemistry of steroids. After postdoctoral studies at the Rockefeller Institute in New York, he joined the scientific staff of the Weizmann Institute.
Mechoulam became a full professor at Hebrew University in 1972 and was named the Lionel Jacobson Professor of Medicinal Chemistry in 1975, serving as the university’s rector from 1979-1982.
In 2022, the YIVO Institute for Jewish Research in New York City mounted its exhibition on Jewish contributions to the history of cannabis and highlighted the work of Mechoulam. “He’s worked on cannabis his entire life, and in the 1990s he and his colleagues discovered the endocannabinoid system, which regulates homeostasis — a significant discovery on how the human body deals with cannabinoids,” Eddy Portnoy, who curated the exhibit, told the Jewish Telegraphic Agency at the time. “I read an interview with him where he says that because he was in a small country, he would have to find a niche that other people weren’t working in.”
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Pope Leo Says God Rejects Prayers of Leaders Who Wage Wars
Pope Leo XIV delivers a homily during the Palm Sunday Mass in Saint Peter’s Square at the Vatican, March 29, 2026. REUTERS/Francesco Fotia
Pope Leo said on Sunday that God rejects the prayers of leaders who start wars and have “hands full of blood,” in unusually forceful remarks as the Iran war entered its second month.
Addressing tens of thousands in St. Peter’s Square on Palm Sunday, the celebration that opens the holy week leading up to Easter for the world’s 1.4 billion Catholics, the pontiff called the conflict “atrocious” and said Jesus cannot be used to justify any wars.
“This is our God: Jesus, King of Peace, who rejects war, whom no one can use to justify war,” Leo, the first US pope, told crowds in brilliant sunshine.
“(Jesus) does not listen to the prayers of those who wage war, but rejects them, saying: ‘Even though you make many prayers, I will not listen: your hands are full of blood,’” he said, citing a Bible passage.
Leo did not specifically name any world leaders, but he has been ramping up criticism of the Iran war in recent weeks.
During an appeal at the end of Sunday’s celebration, the pope lamented that Christians in the Middle East “are suffering the consequences of an atrocious conflict” and may not be able to celebrate Easter.
The pope, who is known for choosing his words carefully, has repeatedly called for an immediate ceasefire in the conflict and said on Monday that military airstrikes are indiscriminate and should be banned.
Some US officials have invoked Christian language to justify the joint US-Israeli strikes on Iran on February 28 that initiated the expanding war.
US Defense Secretary Pete Hegseth, who has started leading Christian prayer services at the Pentagon, prayed at a service on Wednesday for “overwhelming violence of action against those who deserve no mercy.”
In his homily on Sunday, Leo referenced a Bible passage in which Jesus, about to be arrested ahead of his crucifixion, rebuked one of his followers for striking the person arresting him with a sword.
“(Jesus) did not arm himself, or defend himself, or fight any war,” Leo said. “He revealed the gentle face of God, who always rejects violence. Rather than saving himself, he allowed himself to be nailed to the cross.”
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Netanyahu: Israel to Expand Security Zone in Lebanon
Israeli Prime Minister Benjamin Netanyahu speaks during a press conference, amid the US-Israel conflict with Iran, in Jerusalem, March 19, 2026. Photo: REUTERS/Ronen Zvulun/Pool
i24 News – Prime Minister Benjamin Netanyahu said on Sunday that Israel is conducting a multi-sector campaign against Iran and its proxies, including Hezbollah and Hamas, while expanding security belts in Lebanon, Syria, and Gaza. He made the remarks following a situation assessment at Northern Command with top military officials.
Speaking to commanders, Netanyahu said the Israel Defense Forces (IDF) are “the active side, we are the attacking side, we are the initiating side – and we are deep in their territory.” He added that the campaign has caused “visible cracks in the terrorist regime in Tehran” and is fundamentally changing the security dynamics in the region.
Netanyahu detailed the creation of three security belts: in Syria, from the crest of Mount Hermon to Yarmouk; across more than half of the Gaza Strip; and in Lebanon, where he instructed further expansion to reduce the risk of anti-tank missile attacks on Israel’s border.
The prime minister emphasized the destruction of Hezbollah’s missile capabilities, saying, “We eliminated Nasrallah. We eliminated thousands of Hezbollah terrorists, and above all, we eliminated the enormous threat of 150,000 missiles and rockets, which were intended to destroy Israeli cities.” He acknowledged that Hezbollah still retains a residual ability to launch rockets and said the military is developing plans to address the remaining threat.
Netanyahu addressed northern residents directly, urging patience and resilience, noting that the government ministries had been instructed to provide assistance. He expressed condolences to the families of fallen soldiers and thanked IDF personnel, reservists, and their families for their service.
He said the operations reflect a new Israeli security concept focused on initiative and offensive action against threats and reiterated the government’s determination to continue the campaign until the threats are neutralized. “We are determined, we are fighting, and with God’s help – we are winning,” Netanyahu said.
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‘JD or Marco?’: Iran War Raises 2028 Stakes as Trump Weighs Vance Vs. Rubio
U.S. President Donald Trump takes questions from reporters while Vice President JD Vance and Secretary of State Marco Rubio look on, as they attend a meeting with oil industry executives, at the White House in Washington, D.C., U.S., January 9, 2026. REUTERS/Kevin Lamarque
As the war in Iran threatens to imperil President Donald Trump’s legacy, the political stakes also are rising for two of his top lieutenants: Vice President JD Vance and Secretary of State Marco Rubio.
The pair, widely viewed as potential successors to Trump, have been thrust into still-developing negotiations to end the war at a moment when the Republican Party is already weighing its post-Trump future.
Vance has taken a cautious approach, reflecting his skepticism toward prolonged US military involvement, while Rubio has aligned himself closely with Trump’s hawkish stance and emerged as one of the administration’s most vocal defenders of the campaign.
Trump has said both men were involved in efforts to force Iran to accept US demands to dismantle its nuclear and ballistic missile programs and allow oil traffic to pass freely through the Strait of Hormuz.
With the next presidential election due in 2028 and term limits barring Trump from running again, the president has been putting the succession question to allies and advisers in private, asking “JD or Marco?,” two people familiar with his views said.
The outcome of the US military operation now in its fifth week could shape the two men’s 2028 prospects, political analysts and Republican officials said. A swift end to the war that favors the US might bolster Rubio, who also serves as Trump’s national security adviser and could be seen as a steady hand during a crisis. A prolonged conflict could give Vance space to argue he reflected the anti-war instincts of Trump’s base without openly breaking with the president.
Trump’s own standing is also at stake. His approval rating fell in recent days to 36 percent, its lowest point since he returned to the White House, hit by a surge in fuel prices and widespread disapproval of the Iran war, a four-day Reuters/Ipsos poll completed last week found.
Some Republicans say they are watching closely for which senior aide Trump appears to favor as the Iran conflict unfolds. Some see signs of Trump leaning toward Rubio but note he could change his mind quickly.
“Everyone is watching the body language that Trump makes on Rubio and not seeing the same on Vance,” a Republican with close ties to the White House said.
The White House rejected the idea that Trump is signaling a preference.
“No amount of crazed media speculation about Vice President Vance and Secretary Rubio will deter this administration’s mission of fighting for the American people,” spokesman Steven Cheung said.
FROM TRUMP RIVALS TO LIKELY HEIRS
Vance, 41, a former Marine who served in Iraq, has long argued against US entanglements in foreign wars. His public comments on Iran have been limited and calibrated, and Trump has noted the two have “philosophical differences” on the conflict.
Once a self-described “never-Trumper,” Vance wrote an opinion piece in the Wall Street Journal in 2023 saying Trump’s best foreign policy was not starting any wars during his first four years in office between 2017 and 2021.
The White House has downplayed any rift between the president and vice president. Standing alongside Trump in the Oval Office earlier this month, Vance said he supported Trump’s handling of the war and agreed with him that Iran should not obtain a nuclear weapon.
Vance could take on a more direct role in negotiations if Trump’s special envoy Steve Witkoff and son-in-law Jared Kushner make sufficient progress, a person with knowledge of the matter said.
“Vice President Vance is proud to be a part of a highly effective team that, under President Trump’s bold leadership, has had incredible success in making America safer, more secure and more prosperous,” a Vance spokeswoman said.
A senior White House official, who like others in this story was granted anonymity to speak freely about a sensitive topic, said Trump tolerates ideological differences as long as aides remain loyal, adding that Vance’s skeptical views have helped inform Trump about where part of his voter base stands.
A person familiar with Vance’s views told Reuters the vice president will wait until after the November midterm elections before deciding on whether to run in 2028.
Vance won the straw poll at the Conservative Political Action Conference’s annual gathering, with about 53 percent of the more than 1,600 attendees who voted favoring him as the next Republican nominee. The results released on Saturday also showed Rubio gaining ground, finishing second at 35 percent, up from just 3 percent last year.
Rubio, 54, has said he will not run for president if Vance does, and sources familiar with Rubio’s views say he would be content as Vance’s running mate.
But any perceived vulnerability for Vance could encourage Rubio and other Republicans eyeing bids.
“Trump has a long memory,” said Republican strategist Ron Bonjean. “And he may call out Vance for his lack of allegiance. And if Trump remains popular with the MAGA base, that could hurt him by not getting the endorsement of the president.”
Trump has floated the idea of Vance and Rubio running together, suggesting they would be hard to beat.
“Trump doesn’t want to anoint anyone,” the senior White House official said.
A March Reuters/Ipsos poll found that 79 percent of Republicans have a favorable view of Vance, while 19 percent viewed him negatively. Some 71 percent had a positive view of Rubio, while 15 percent viewed him unfavorably.
In comparison, 79 percent of Republicans viewed Trump favorably and 20% unfavorably.
Rubio, whose 2016 presidential aspirations were snuffed out after a bitter confrontation with Trump, has long since set aside any frictions with the president.
State Department spokesman Tommy Pigott said Rubio “has a great relationship, both professionally and personally” with Trump’s team.
Rubio and the White House were forced into damage control after he angered some of Trump’s conservative backers when he suggested that Israel pushed the United States into the war. But in the weeks since, Trump has praised Rubio’s efforts.
Asked whether Rubio was concerned that a protracted war might damage his political future, a senior State Department official said, “He has not spent a second thinking about this.”
DIFFERENCES ON DISPLAY
Matt Schlapp, a conservative leader who runs CPAC, said the Iran campaign will have big political consequences.
“If it is seen as successful at getting the job done… I think people will be politically rewarded for doing the right thing,” Schlapp said. “If it goes on and on and on… I think the politics are tough.”
Republicans remain broadly supportive of the US military strikes against Iran, with 75 percent approving compared to just 6 percent of Democrats and 24 percent of independents, Reuters/Ipsos polling showed.
At a televised Cabinet meeting on Thursday, the contrast between Rubio and Vance was on display.
Rubio gave a full-throated defense of Trump’s attack on Iran. “He’s not going to leave a danger like this in place,” the secretary of state said.
Vance was more measured, focusing on options for depriving Iran of a nuclear weapon. He closed by wishing Christians and US troops in the Gulf a blessed Holy Week and Easter.
“We continue to stand behind you,” he said to servicemembers, “and continue to support you every step of the way.”
