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Raphael Mechoulam, Israel’s ‘father of cannabis research,’ dies at 92

(JTA) — In the early 1960s, a Bulgarian-born scientist named Raphael Mechoulam was caught carrying five kilograms of, as he called it, “superb, smuggled Lebanese hashish” on a bus from Tel Aviv to Rehovot. But he wasn’t planning on smoking the stuff.

Mechoulam was a fledgling researcher keen on exploring the science behind cannabis, a stigmatized plant whose specific medical properties were not yet known. Over the decades he became a pioneer in cannabis research, whose findings about the psychoactive substance helped ease its entry out of the counterculture and into the mainstream. 

Mechoulam died in Israel at age 92; his death was announced Friday by American Friends of the Hebrew University, where Mechoulam helped form The Hebrew University Multidisciplinary Center for Cannabinoid Research in 2017.

“Most of the human and scientific knowledge about cannabis was accumulated thanks to Prof. Mechoulam,” Hebrew University President Asher Cohen said in a statement. “He paved the way for groundbreaking studies and initiated scientific cooperation between researchers around the world. Mechoulam was a sharp-minded and charismatic pioneer.”

As a professor in the Hebrew University School of Pharmacy, Mechoulam and his research team isolated THC, the psychoactive component of cannabis, as well as cannabidiol, or CBD, an active ingredient in cannabis with a range of medicinal benefits. 

He also pioneered the study of the body’s own cannabinoid system, which produces chemicals similar to THC to help regulate appetite, manage pain and operate the immune system.

As Mechoulam discovered more about cannabis and its efficacy in easing symptoms of cancer, epilepsy and other diseases, he lamented that strict drug laws in the United States and elsewhere suppressed research and kept the derivatives of cannabis off the market.

“Medicinal cannabis has to follow medical lines of thought and development and modern medical routes” in order to be part of proper drugs, he told the New York Times in 2017. “Israel has more [clinical trials] than the United States at the moment, which is ridiculous.”

Mechoulam was a founding member of the International Association for Cannabinoid Medicines and the International Cannabinoid Research Society. In 1994, he was elected to be a member of the Israel Academy of Sciences and Humanities.

Mechoulam was born in Bulgaria in 1930 and immigrated in 1949 with his family to Israel, where he later studied chemistry. He received his PhD at the Weizmann Institute in Rehovot, writing a thesis on the chemistry of steroids. After postdoctoral studies at the Rockefeller Institute in New York, he joined the scientific staff of the Weizmann Institute.

Mechoulam became a full professor at Hebrew University in 1972 and was named the Lionel Jacobson Professor of Medicinal Chemistry in 1975, serving as the university’s rector from 1979-1982. 

In 2022, the YIVO Institute for Jewish Research in New York City mounted its exhibition on Jewish contributions to the history of cannabis and highlighted the work of Mechoulam. He’s worked on cannabis his entire life, and in the 1990s he and his colleagues discovered the endocannabinoid system, which regulates homeostasis — a significant discovery on how the human body deals with cannabinoids,” Eddy Portnoy, who curated the exhibit, told the Jewish Telegraphic Agency at the time. “I read an interview with him where he says that because he was in a small country, he would have to find a niche that other people weren’t working in.”


The post Raphael Mechoulam, Israel’s ‘father of cannabis research,’ dies at 92 appeared first on Jewish Telegraphic Agency.

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Trump Wants Say on Iran’s Next Leader, Claims Tehran Calling US About a Deal

US President Donald Trump speaks on the day he honors reigning Major League Soccer (MLS) champion Inter Miami CF players and team officials with an event in the East Room of the White House in Washington, DC, US, March 5, 2026. Photo: REUTERS/Jonathan Ernst

US President Donald Trump claimed the right to join Iran in deciding its next leader as the war escalated on Thursday, with US and Israeli jets hitting areas across the country and Gulf cities coming under renewed bombardment.

In a phone interview with Reuters, Trump said Mojtaba Khamenei, the son of the late Supreme Leader Ali Khamenei – a hardliner who has been considered a favorite to succeed his father – was an unlikely choice.

“We want to be involved in the process of choosing the person who is going to lead Iran into the future,” he said.

Trump also encouraged ​Iranian Kurdish forces to go on the offensive.

“I’d be all for it,” said Trump, whose administration has had contact with Iranian Kurdish groups since the US-Israeli strikes began. He would not say whether the United States would provide air cover for any Kurdish offensive.

The attack is a major political gamble for the Republican president, with opinion polls showing little public support and Americans concerned about the rise in gasoline prices caused by disruption to energy supplies. Trump dismissed that concern.

He said later in the day that Tehran was reaching out to the United States about making a deal amid US and Israeli strikes on Iran, adding that further action to reduce pressure on oil was imminent.

“They’re calling, they’re saying ‘how do we make a deal?’ I said you’re being a little bit late,” said Trump, speaking at an event with the Inter Miami soccer team at the White House.

Trump touted the US military actions in Iran, saying they were destroying Tehran’s missile and drone capability and that “their navy is gone – 24 ships in three days,” as he called on Iranian diplomats to request asylum and help shape a better country.

“We also urge Iranian diplomats around the world to request asylum and to help us shape a new and better Iran,” he said.

ISRAELIS WARN TEHRAN RESIDENTS

On the war’s sixth day, Iran launched a series of attacks on Israel, the United Arab Emirates, and Qatar. Fire crews in Bahrain extinguished a blaze at a refinery following a missile strike.

Two drone attacks targeted an Iranian opposition camp in Iraqi Kurdistan, as well as an oil field operated by an American firm, security sources said.

The Israeli military warned residents to evacuate areas including eastern Tehran, while Iranian media reported blasts were heard in various parts of the capital. An air attack killed 17 people in a guest house on a road northwest of the capital, Iranian state television said.

MANY MUNITIONS, IRAN‘S ATTACKS DROPPED

US Defense Secretary Pete Hegseth and Admiral Brad Cooper, who leads US forces in the Middle East, said that the US has enough munitions to continue its bombardment indefinitely.

Iran is hoping that we cannot sustain this, which is a really bad miscalculation,” Hegseth told reporters at Central Command headquarters in Florida. “Our munitions are full up and our will is ironclad.”

Cooper said the US had now hit at least 30 Iranian ships, including a large drone carrier that he said was the size of a World War Two aircraft carrier. He added that B-2 bombers had in the past few hours dropped dozens of 2,000 penetrator bombs targeting deeply buried ballistic missile launchers, and that bombings were also targeting Iran‘s missile production facilities.

Iran‘s ballistic missile attacks had decreased by 90% since the first day of the war, while drone attacks had decreased by 83% in that time frame, he said.

WARNING SIRENS BLARE IN MULTIPLE NATIONS

Azerbaijan on Thursday became the latest country drawn in, as it accused Iran of firing drones at its territory and ordered its southern airspace closed for 12 hours. Iran, which has a significant Azeri minority, denied it had targeted its neighbor, but the episode underlined how rapidly the war has spread since the surprise US and Israeli airstrikes that killed Khamenei on Saturday.

Along with the gleaming cities of the Gulf, in easy range of Iranian drones and missiles, Cyprus and Turkey have both been targeted. European nations have pledged to deploy ships to the eastern Mediterranean and hostilities have been seen as far afield as waters off Sri Lanka, where a US submarine sank an Iranian warship on Tuesday, killing 80 crew members.

In Iran, at least 1,230 people have been killed, according to the Iranian Red Crescent Society, including 175 schoolgirls and staff killed at a primary school in Minab in the country’s south on the first day of the war. Another 77 have been killed in Lebanon, its Health Ministry says. Thousands fled southern Beirut on Thursday after Israel warned residents to leave.

NETANYAHU SAYS ‘MUCH WORK STILL LIES AHEAD’

Shares on Wall Street fell on Thursday, weighed by surging oil prices, as the economic impact of the campaign intensified, with countries around the world cut off from a fifth of global supplies of oil and liquefied natural gas and air transport still facing chaos and global logistics increasingly snarled.

On Thursday, Iran‘s Revolutionary Guards said they had hit a US tanker in the northern part of the Gulf and the vessel was on fire, the latest of numerous reports of such attacks.

Visiting an air force base in the south of the country, Israeli Prime Minister Benjamin Netanyahu said Israel’s achievements so far in Iran had been “great” but that “much work still lies ahead.”

Iran‘s foreign minister said Washington would “bitterly regret” the precedent it had set by sinking a ship in international waters without warning. A commander of the Revolutionary Guards, General Kioumars Heydari, told state TV: “We have decided to fight Americans wherever they are.”

The body of Supreme Leader Ayatollah Ali Khamenei, killed in the first hours of the US-Israeli air campaign in the first assassination of a country’s top ruler by an airstrike, had been due to lie in state in a Tehran prayer hall from Wednesday evening to launch three days of mourning.

But the memorial, expected to draw many thousands of mourners to the streets, was abruptly postponed.

Two sources familiar with Israel’s battle plans said that Israel, having killed many Iranian leaders, was now planning to enter a second phase when it would target underground bunkers where Iran stores its missiles.

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Israel Decided to Kill Khamenei in November, Defense Minister Says

Israel’s Defense Minister Israel Katz and his Greek counterpart Nikos Dendias make statements to the press, at the Ministry of Defense in Athens Greece, Jan. 20, 2026. Photo: REUTERS/Louisa Gouliamaki

Israel took the decision to kill Iran’s Supreme Leader Ali Khamenei in November and was planning to carry out the operation around six months later, Defense Minister Israel Katz said on Thursday.

Khamenei was killed in the first hours of the US-Israeli air campaign that began on Saturday in the first assassination of a country’s top ruler by an airstrike.

The joint air assault is nearing the end of its first week after opening salvos killed the country’s leaders and set off a regional war, with Iranian attacks in Israel, the Gulf and Iraq, and Israeli attacks against Iran’s ally Hezbollah in Lebanon.

“Already in November we were convened with the prime minister in a very tight forum and the prime minister [Benjamin Netanyahu] set the goal of eliminating Khamenei,” Katz told Israel‘s N12 TV news. The timing was set for mid-2026, he said.

The plan was eventually shared with the Washington and brought forward around January after protests broke out Iran, when Israel was concerned its pressured clerical rulers might launch an attack against Israel and US assets in the Middle East, Katz said.

Israel has said its aim is to eliminate the existential threat it sees in Iran’s nuclear program and ballistic missile project, and to bring about regime change. Iran’s rulers have so far shown no sign of relinquishing power.

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China in Talks With Iran to Allow Safe Oil and Gas Passage Through Hormuz, Sources Say

An oil tanker unloads crude oil at a crude oil terminal in Zhoushan, Zhejiang province, China, July 4, 2018. Picture taken July 4, 2018. Photo: REUTERS/Stringer

China is in talks with Iran to allow crude oil and Qatari liquefied natural gas vessels safe passage through the Strait of Hormuz as the US-Israeli war on Tehran intensifies, three diplomatic sources told Reuters.

The war, which entered its sixth day on Thursday, has left the critical shipping passageway all-but shut, with countries around the world cut off from a fifth of global oil and liquefied natural gas supplies.

China, which has friendly relations with Iran and relies heavily on Middle Eastern supplies, is unhappy about the Islamic Republic’s move to paralyze shipping through the Strait and is pressing Tehran to allow safe passage for the vessels, according to the sources.

The world’s second-largest economy gets about 45% of its oil from the Strait.

Ship tracking data showed a vessel called the Iron Maiden passed through the Strait overnight after changing its signaling to “China-owner,” but far more sailings will be needed to calm global markets.

Crude oil prices are up more than 15% since the conflict began amid production stoppages as Tehran attacks energy facilities in the Gulf as well as ships crossing the Strait.

Its missiles have also reached as far afield as Cyprus, Azerbaijan, and Turkey, destabilizing global markets and prompting major economies to warn about inflation risks.

Crude ​tanker transits through the strait fell ​to ⁠four vessels on March 1, the day after hostilities broke out, versus an average of 24 a day ⁠since ​January, Vortexa vessel-tracking data showed.

Around 300 oil tankers remain inside the Strait, according to Vortexa and ship tracker Kpler.

Sugar industry veteran Mike McDougall told Reuters that Middle East sugar executives say there are some ships transiting the Strait at the moment, all of which are either Chinese or Iranian-owned.

Jamal Al-Ghurair, the managing director of Dubai-based Al Khaleej Sugar, told Reuters some ships carrying sugar are currently allowed to pass through the Strait while others are not, without giving further details.

Iran‘s government said earlier in the week that no vessels belonging to the United States, Israel, European countries or their allies would be allowed to pass through the Strait of Hormuz, but the statement made no mention of China.

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