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Raphael Mechoulam, Israel’s ‘father of cannabis research,’ dies at 92

(JTA) — In the early 1960s, a Bulgarian-born scientist named Raphael Mechoulam was caught carrying five kilograms of, as he called it, “superb, smuggled Lebanese hashish” on a bus from Tel Aviv to Rehovot. But he wasn’t planning on smoking the stuff.

Mechoulam was a fledgling researcher keen on exploring the science behind cannabis, a stigmatized plant whose specific medical properties were not yet known. Over the decades he became a pioneer in cannabis research, whose findings about the psychoactive substance helped ease its entry out of the counterculture and into the mainstream. 

Mechoulam died in Israel at age 92; his death was announced Friday by American Friends of the Hebrew University, where Mechoulam helped form The Hebrew University Multidisciplinary Center for Cannabinoid Research in 2017.

“Most of the human and scientific knowledge about cannabis was accumulated thanks to Prof. Mechoulam,” Hebrew University President Asher Cohen said in a statement. “He paved the way for groundbreaking studies and initiated scientific cooperation between researchers around the world. Mechoulam was a sharp-minded and charismatic pioneer.”

As a professor in the Hebrew University School of Pharmacy, Mechoulam and his research team isolated THC, the psychoactive component of cannabis, as well as cannabidiol, or CBD, an active ingredient in cannabis with a range of medicinal benefits. 

He also pioneered the study of the body’s own cannabinoid system, which produces chemicals similar to THC to help regulate appetite, manage pain and operate the immune system.

As Mechoulam discovered more about cannabis and its efficacy in easing symptoms of cancer, epilepsy and other diseases, he lamented that strict drug laws in the United States and elsewhere suppressed research and kept the derivatives of cannabis off the market.

“Medicinal cannabis has to follow medical lines of thought and development and modern medical routes” in order to be part of proper drugs, he told the New York Times in 2017. “Israel has more [clinical trials] than the United States at the moment, which is ridiculous.”

Mechoulam was a founding member of the International Association for Cannabinoid Medicines and the International Cannabinoid Research Society. In 1994, he was elected to be a member of the Israel Academy of Sciences and Humanities.

Mechoulam was born in Bulgaria in 1930 and immigrated in 1949 with his family to Israel, where he later studied chemistry. He received his PhD at the Weizmann Institute in Rehovot, writing a thesis on the chemistry of steroids. After postdoctoral studies at the Rockefeller Institute in New York, he joined the scientific staff of the Weizmann Institute.

Mechoulam became a full professor at Hebrew University in 1972 and was named the Lionel Jacobson Professor of Medicinal Chemistry in 1975, serving as the university’s rector from 1979-1982. 

In 2022, the YIVO Institute for Jewish Research in New York City mounted its exhibition on Jewish contributions to the history of cannabis and highlighted the work of Mechoulam. He’s worked on cannabis his entire life, and in the 1990s he and his colleagues discovered the endocannabinoid system, which regulates homeostasis — a significant discovery on how the human body deals with cannabinoids,” Eddy Portnoy, who curated the exhibit, told the Jewish Telegraphic Agency at the time. “I read an interview with him where he says that because he was in a small country, he would have to find a niche that other people weren’t working in.”


The post Raphael Mechoulam, Israel’s ‘father of cannabis research,’ dies at 92 appeared first on Jewish Telegraphic Agency.

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US Hails Progress in Ukraine Peace Talks But Security Questions Unresolved

US Special Envoy Steve Witkoff, US Secretary of State Marco Rubio, US Army Secretary Daniel Driscoll and and other members of the US delegation, and Head of the Office of the President of Ukraine Andriy Yermak and other members of the Ukrainian delegation sit before closed-door talks on ending Russia’s war in Ukraine, at the US Mission in Geneva, Switzerland, November 23, 2025. Photo: REUTERS/Emma Farge

The United States said it had made significant progress on crafting a plan to end the war in Ukraine during talks on Sunday but no agreement was reached on how to guarantee Kyiv’s security amid concerns about the threat posed by Russia.

US Secretary of State Marco Rubio led the talks in Geneva with a high-level Ukrainian delegation after Kyiv and its allies voiced alarm about a US-backed plan because of what they saw as major concessions to Russia, and pressed for changes.

Rubio said work remained to be done on questions including the role of NATO and security guarantees for Ukraine, but that his team had narrowed down unresolved issues in a 28-point peace plan for Ukraine championed by President Donald Trump.

“And we have achieved that today in a very substantial way,” Rubio told reporters at the US mission in Geneva.

Earlier, Trump said Ukraine had not been grateful for American efforts over the war, prompting Ukrainian officials to stress their gratitude to the US president for his support.

European officials joined the US and Ukrainian delegations for talks late on Sunday after crafting a modified version of the US plan for Ukraine that pushes back on proposed limits to Kyiv’s armed forces and mooted territorial concessions.

The European plan proposes that Ukraine be granted a larger military than under the US plan and that talks on land swaps should start from the front line rather than a pre-determined view of which areas should be considered Russian.

On Friday, Trump said Ukrainian President Volodymyr Zelensky had until Thursday to approve the plan, which calls on Ukraine to cede territory, accept limits on its military and renounce ambitions to join NATO.

For many Ukrainians, including soldiers fighting on the front lines, such terms would amount to capitulation after nearly four years of fighting in Europe’s deadliest conflict since World War Two. On Saturday, Trump said the current proposal for ending the war is not his final offer.

Rubio said the United States still needed time to address the pending issues. He hoped a deal could be reached by Thursday but suggested that it could also take longer.

US and Ukrainian officials were discussing the possibility of Zelensky traveling to the United States, maybe as early as this week, to discuss the peace plan with Trump, two sources familiar with matter said on Sunday.

The main idea is that they would discuss the most sensitive issues in the peace plan, such as the matter of territory, one of the sources said. There is no confirmed date for now, the source added.

ORIGIN OF U.S. PLAN STIRS CONTROVERSY

The main talks between US and Ukrainian officials got under way in a stiff atmosphere at the US mission, soon after Trump complained in a Truth Social post that Ukraine’s leadership had shown “zero gratitude” to the US for its efforts and Europe continued to buy Russian oil.

Rubio interrupted the meeting to speak to reporters, saying the talks had been probably the best the US had held with Ukraine since Trump returned to power.

He said changes would be made to the plan to work towards a solution that both Ukraine and the US could support.

“Obviously this will ultimately have to be signed off with our presidents, although I feel very comfortable about that happening given the progress we’ve made,” said Rubio.

Andriy Yermak, head of the Ukrainian delegation, was at pains to thank Trump for his commitment to Kyiv during the brief interlude. Minutes later, Zelensky also thanked Trump.

Yermak did not reappear with Rubio when the talks ended.

Since the US plan was announced, there has been confusion about who was involved in drawing it up. European allies said they had not been consulted.

Before heading to Geneva, Rubio insisted on X that Washington had authored the plan after remarks from some US senators suggesting otherwise.

Senator Angus King said Rubio had told senators the plan was not the administration’s position, but “essentially the wish-list of the Russians.”

A PERILOUS MOMENT FOR UKRAINE

The draft US plan, which includes many of Russia’s key demands and offers only vague assurances to Ukraine of “robust security guarantees,” comes at a perilous moment for Kyiv.

Russia has been making gains on parts of the front, albeit slowly and, according to Western and Ukrainian officials, the advances have been extremely costly in terms of lives lost.

The transportation hub of Pokrovsk has been partially taken by Russian forces and Ukrainian commanders say they do not have enough soldiers to prevent small, persistent incursions.

Ukraine’s power and gas facilities have been pummeled by drone and missile attacks, meaning millions of people are without water, heating and power for hours each day.

Zelensky himself has been under pressure domestically after a major corruption scandal broke, ensnaring some of his ministers and people in his close entourage.

He has warned that Ukraine risked losing its dignity and freedom – or Washington’s backing – over the US plan.

Kyiv had taken heart in recent weeks after the United States tightened sanctions on Russia’s oil sector, the main source of funding for the war, while its own long-range drone and missile strikes have caused considerable damage to the industry.

But the draft peace plan appears to hand the diplomatic advantage back to Moscow. Ukraine relies heavily on US intelligence and weapons to sustain its war against Russia.

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Who Was Tabtabai, Hezbollah’s Military Leader Killed by Israel?

People inspect a damaged building, after Israeli military said on Sunday that it struck a militant from the Lebanese Iran-aligned Hezbollah group, in Beirut’s southern suburbs, Lebanon November 23, 2025. Photo: REUTERS/Mohammed Yassin

The Israeli military on Sunday killed Hezbollah’s top military official, Haytham Ali Tabtabai, in a strike on the outskirts of the Lebanese capital that came despite a year-long ceasefire.

His killing was announced by Israel’s military. Hezbollah later confirmed his death, hailing him as “the great jihadist commander” who had “worked to confront the Israeli enemy until the last moment of his blessed life.”

Israel had already eliminated most of Iran-backed Hezbollah’s leadership during a war that raged between October 2023 and November 2024, when a US-brokered truce was agreed.

But Tabtabai, who was appointed as the group’s chief of staff after its recent war with Israel, was killed in a rare post-ceasefire operation against a senior Hezbollah figure.

MILITARY LEADER ROSE THROUGH HEZBOLLAH’S RANKS

Tabtabai was born in Lebanon in 1968 to a father with Iranian roots and a Lebanese mother, according to a senior Lebanese security source. He was not a founding member of Hezbollah but was part of its “second generation,” deploying with the group to fight alongside its allies in Syria and Yemen, the source said.

Israel’s military said Tabtabai joined Hezbollah in the 1980s and held several senior posts, including in its Radwan Force, an elite fighting unit. Israel killed most Radwan figures last year ahead of its ground invasion into Lebanon.

During last year’s war, Tabtabai led Hezbollah’s operations division and rose in rank as other top commanders were eliminated, the Israeli military’s statement said.

Once the ceasefire came into force, Tabtabai was appointed chief of staff and “worked extensively to restore their readiness for war with Israel,” according to the statement.

The Lebanese security source confirmed Tabtabai was swiftly promoted as other top Hezbollah officials were killed, and had been appointed chief of staff over the last year.

The Alma Center, a security research and teaching organization in Israel, said Tabtabai had survived other Israeli attacks both in Syria and during the war in Lebanon.

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Netanyahu, Smotrich to Meet on Israeli 2026 Budget that Faces Battle for Approval

Israeli Prime Minister Benjamin Netanyahu speaks with Minister of Finance Bezalel Smotrich during the weekly cabinet meeting at the Defense Ministry in Tel Aviv, Israel, January 7, 2024. Photo: REUTERS/Ronen Zvulun/Pool

Israeli Finance Minister Bezalel Smotrich and senior ministry officials will present Prime Minister Benjamin Netanyahu later on Sunday with the state budget and planned structural reforms for 2026, Smotrich’s office said.

“The Finance Minister will present to the Prime Minister the necessary measures to ensure continued economic growth and to combat the high cost of living,” it said.

It added that cabinet ministers would vote on the budget on Dec. 4 but it is unlikely the budget would be approved by year end.

According to Israeli law, the budget must be approved by parliament by the end of March or new elections are triggered.

Its final approval faces an uphill battle that could ultimately lead to new elections.

The government has splintered in the past two years over the Gaza war, the ceasefire which has halted it and demands by ultra-Orthodox Jewish parties to exempt Jewish seminary students from mandatory military service.

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