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Could a Nuclear War with Iran Really Happen?
Military personnel stand guard at a nuclear facility in the Zardanjan area of Isfahan, Iran, April 19, 2024. Photo: West Asia News Agency via REUTERS
For the moment, as Iran remains “pre-nuclear,” an Israel-Iran nuclear exchange is out of the question. Nonetheless, if Israel is able to maintain its asymmetrical nuclear advantage, a one-sided nuclear war would still be possible. Circumstances could sometime arise in which Israel felt compelled to launch parts of its “ambiguous” nuclear arsenal against Iran. The most plausible rationale of any such launch would be to (1) prevent Iranian “escalation dominance;” and (2) keep Iran from “becoming nuclear.”
In offering suitable explanations, recent history will show that during April 2024, Israel and Iran engaged in a brief but direct interstate conflict. Looking ahead, it would be reasonable to expect additional rounds of direct warfare between these two bitter adversaries. Conflict durations could be much longer and more protracted. It follows that Israel would be under expanding pressures to dominate escalation during periods of hyper-warfare with Iran and that such potentially existential pressures could precipitate an Israeli resort to nuclear weapons use.
Above all else, Israel’s strategic objective vis-à-vis Iran should be nuclear war avoidance. In a near worst-case scenario, Israel could calculate that nothing short of massive non-nuclear preemption would halt Tehran’s ongoing nuclearization.
An Israeli nuclear preemption is inconceivable. But even if Israel’s determination to launch a non-nuclear preemption were analytically correct and law-enforcing, its tangible results could still be catastrophic.
What should now be done by Jerusalem? How should principal Israeli decision-makers balance these dissuasive results against all calculable risks and benefits?
A best answer should be drawn from conceptual and theoretical fundamentals. Israeli strategists should always examine their country’s available security options as an intellectual rather than political task.
There will be pertinent details, both conspicuous and inconspicuous. Any tactically successful conventional preemption against Iranian weapons and infrastructures could come at more-or-less unacceptable costs. In 2003-2004, when this writer’s Project Daniel Group presented an early report on Iranian nuclearization to then Prime Minister Ariel Sharon, prospective Iranian targets were already more directly threatening to Israel than Iraq’s nuclear Osirak reactor had been on June 7, 1981. That was the date of Israel’s law-based preemption, an operation code-named “Opera.”
To the extent that they could be estimated accurately, the risks of an Israel-Iran nuclear war would ultimately depend on whether the conflict was intentional, unintentional, or accidental. Apart from applying this critical three-part distinction, there would be no good reason to expect optimally useful strategic assessments from Tel Aviv (MOD/IDF).
Once applied, however, Israeli planners should fully understand that their complex subject is without any clarifying precedents, and that this absence would present an insurmountable prediction problem.
It will also be obligatory for Israeli strategists and war planners to bear in mind the timeless warnings of Prussian thinker Karl von Clausewitz on the role of “friction.” At its core, friction represents “the difference between war on paper and war as it actually is.”
Peremptory rules of logic and mathematics preclude any meaningful assignments of probability in matters that are unprecedented or sui generis. To come up with any logically-meaningful estimations of probability, these predictions would have to be based upon the determinable frequency of relevant past events. As there have been no occasions of an interstate nuclear exchange, there could be no relevant past events.
Competent Israeli strategic analysts must examine all current and future nuclear risks from Iran. Such a comprehensive examination should take special note of Iran’s radiation dispersal weapons and its potential capacity to attack Israel’s Dimona nuclear reactor with non-nuclear missiles. Also worth emphasizing is that North Korea, bolstered by Russia and China, has been a clamorous ally of Iran, and could sometime allow its national nuclear forces to serve as Iranian proxies during a protracted war with Israel.
If any Israeli planners should assume that a “Trump II” presidency could help in such unpredictable scenarios, they ought first to recall Trump’s ambiguous summarizing message after the Singapore Summit: “We [Trump and Kim] fell in love.”
Following their Singapore meeting, Trump and Kim each seemed to assume the other’s decisional rationality and also the mutual primacy of decisional intent. If such an assumption had not existed, it would have made no logical sense for either president to strike existential retaliatory fear in the other. But what are the derivative lessons of “Singapore” for Israel vis-à-vis Iran? Should Israel also assume a fully rational adversary in Iran? Though any such assumption would be more or less reassuring in Jerusalem’s decision-making circles, it could also be incorrect.
On several occasions during his presidential tenure, Donald Trump praised pretended irrationality as a potentially promising US nuclear strategy. But such a strategic preference could never be purposeful for Israel. This is the case despite Moshe Dayan’s much earlier musing about Israel and its enemies: “Israel must be seen as a mad dog, too dangerous to bother.”
Though neither Israel nor Iran might prefer conditions of a steadily escalating war, either or both “players” could still commit catastrophic errors during their obligatory searches for “escalation dominance.” If Jerusalem and Tehran undertake competitive risk-taking in extremis, Israel’s only reliable “ace in the hole” will be its continuing nuclear monopoly.
An unintentional or inadvertent nuclear war between Israel and Iran could take place not only as the result of misunderstandings or miscalculations between rational leaders, but also as the unintended consequence of mechanical, electrical, or computer malfunction. This includes hacking interference and should bring to mind corollary distinctions between unintentional or inadvertent nuclear war and an accidental nuclear war.
Though all accidental nuclear war would be unintentional, not every unintentional nuclear war would be caused by accident. An unintentional or inadvertent nuclear war could sometime be the result of certain misjudgments about enemy intentions.
“In war,” says Prussian strategist Carl von Clausewitz famously in On War, “everything is simple, but the simplest thing is difficult.” Fashioning a successful “endgame” to any impending future nuclear confrontation with Iran, Israel’s leaders will need to understand that a crisis in extremis is inevitably about more than maximizing any “correlation of forces” or “missile-interception” capabilities. It will be about variously antecedent Israeli triumphs of “mind over mind.”
As a nuclear war has never been fought, what will be needed in Jerusalem is more broadly intellectual guidance than Israel could ever reasonably expect from even its most senior and capable military officers.
The reason is simple.
There are no plausible experts on fighting an unprecedented kind of war, not in Jerusalem, not in Tehran, not anywhere. It was not by happenstance that the first serious theoreticians of nuclear war and nuclear deterrence in the 1950s were academic mathematicians, physicists, and political scientists. Having to deal with matters that lacked usable historic or empirical data, these thinkers were forced to rely essentially on deductive logic, deriving their essential strategic theories from meticulously assembled abstractions.
There remains one final point about still-estimable risks of an Israel-Iran nuclear war. From the standpoint of Jerusalem, the only truly successful outcome would be a crisis or confrontation that ends with a reduction of Iranian nuclear war fighting intentions and capabilities. It would represent a serious mistake for Israel to settle for any bloated boasts of “victory” based upon a one-time avoidance of nuclear war. In this geo-strategic conflict with Iran, potentially existential dangers to Israel are foreseeably continuous.
The Israel-Iran strategic conflict is self-propelling. For Jerusalem, providing Israeli national security vis-à-vis a steadily-nuclearizing Iran ought never to become an ad hoc or “seat-of-the-pants” struggle. Without any suitably long-term plan in place for avoiding an atomic war, a nuclear conflict that is deliberate, unintentional or accidental could “sometimes happen.”
At every stage of its corrosive competition with Tehran, Israel should avoid losing sight of the only rational use for its presumptive nuclear weapons and doctrine. That limited use is to maintain Israeli “escalation dominance” during military crisis and to prevent an operationally usable Iranian nuclear force. More generally, nuclear weapons can succeed only as instruments of strategic deterrence and nuclear war avoidance. By reasonable definition, any actual use of a state’s nuclear weapons would “automatically” signify their failure. Israel ought to view ongoing “asymmetrical” conflict with Iran as the preferred context for preventing Iranian nuclear weapons.
There is something else. In the absence of such conflict, an already nuclear Israel could still exercise a preemption option against a pre-nuclear Iran, but only as a “bolt-from-the-blue” attack. Though this particular sort of action could fulfil all authoritative expectations of “anticipatory self-defense” under international law, it would be vastly more difficult to support in political and public relations terms.
What if Israel and Iran were both “already nuclear”? In such a next-to-worst case scenario, Israel, having failed to act in a timely fashion, could have to strike preemptively against a more menacing adversary. In a worst case scenario, Israel would fail to prevent a nuclear Iran, and Iran would become the first adversary to fire its nuclear weapons. Certain specific Arab states could rush to join the “nuclear club.” In all likelihood, these states — potentially joined by Turkey — would be Egypt, Saudi Arabia and the United Arab Emirates (UAE).
Summarizing all these “strategy of conflict” issues in policy-relevant terms, Israel’s only cost-effective strategy would be to prevent Iranian nuclearization and correlative Arab state nuclearization by dominating escalations during a non-nuclear war or an asymmetrical nuclear war. Ideally, such a strategy would be exercised during the course of an already-ongoing armed conflict, though Israel could, as last resort, plan “bolt-from-the-blue” strikes against Iranian hard targets that are convincingly lawful expressions of national survival options. Under international law, these permissible strikes would be examples of “anticipatory self-defense.”
In the end, we are all creatures of biology. For Israel and Iran, a nuclear war would resemble any other incurable disease. For both, therefore, the only reasonable survival strategies must lie in prevention.
Louis René Beres was educated at Princeton (Ph.D., 1971) and is the author of many books, monographs, and scholarly articles dealing with military nuclear strategy. In Israel, he was Chair of Project Daniel. Over recent years, he has published on nuclear warfare issues in Harvard National Security Journal (Harvard Law School); Bulletin of the Atomic Scientists; International Journal of Intelligence and Counterintelligence; Israel Journal of Foreign Affairs; The Atlantic; Israel Defense; Jewish Website; The New York Times; Israel National News; The Jerusalem Post; The Hill and other sites. A different version of this article was originally published by Israel National News.
The post Could a Nuclear War with Iran Really Happen? first appeared on Algemeiner.com.
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As Gaza War Continues, Hamas Calls for Global Protests While Israel Marks Breakthroughs in Medical Innovation

A pro-Hamas march in London, United Kingdom, Feb. 17, 2024. Photo: Chrissa Giannakoudi via Reuters Connect
As the Palestinian terrorist group Hamas calls for global protests amid stalled Gaza ceasefire talks, Israel has broken new ground despite the ongoing conflict, achieving a major medical breakthrough in synthetic human kidney development.
The contrast illustrates a stark contrast between the priorities of Hamas, an international designated terrorist group that has ruled Gaza for nearly two decades, and Israel, the lone democracy in the Middle East that has long been a leader in tech and medical innovation.
On Wednesday, Hamas urged worldwide protests in support of Palestinians, calling on the international community “to denounce Israel’s genocidal war and starvation policy in Gaza.”
“We call for continuing and escalating the popular pressure in all cities and squares on Friday, Saturday, and Sunday … through rallies, demonstrations and sit-ins outside the embassies of the Israeli regime and its allies, particularly in the US,” the statement read.
The Palestinian terrorist group also called to expose what it described as “the terrorism of the Zio-Nazi occupation against defenseless civilians.”
Hamas’s latest move against Israel comes amid stalled indirect negotiations over a proposed 60-day ceasefire and hostage release deal, which collapsed last month after the group vowed it would not disarm unless an independent Palestinian state is established — rejecting a key Israeli demand to end the war in Gaza.
In its statement, Hamas demanded the opening of all border crossings to allow immediate aid into the war-torn enclave and urged a global condemnation of “the international community’s inaction on the Israeli crimes.”
Amid mounting international pressure to address the humanitarian crisis in Gaza, Israel announced new measures to facilitate the delivery of aid, including temporary pauses in fighting in certain areas and the creation of protected routes for aid convoys.
Israeli officials have previously accused Hamas of diverting aid for terrorist activities and selling supplies at inflated prices to civilians, while also blaming the United Nations and other foreign organizations for enabling this diversion.
Hamas’s statement also emphasized that the “global resistance movement must continue until Israeli aggression on Gaza ends and the siege on the coastal strip is lifted.”
Meanwhile, as Israel faces escalating hostilities and the heavy toll of war, the Jewish state continues to push the boundaries of innovation and resilience, achieving new medical breakthroughs while confronting ongoing challenges.
In a major medical breakthrough, scientists at Sheba Medical Center and Tel Aviv University have successfully grown a synthetic 3D miniature human kidney in a lab using specialized stem cells derived from kidney tissue — one of the most promising advances in regenerative medicine.
Dr. Dror Harats, chairman of Sheba’s Research Authority, described this achievement as a reflection of Israel’s leading role in global medical innovation.
“Despite growing efforts to isolate Israel from international science, breakthroughs like this prove our impact is both lasting and essential,” he said.
In a landmark study, a team from Sheba’s Safra Children’s Hospital and Tel Aviv University’s Sagol Center for Regenerative Medicine created synthetic kidney organs that matured and remained stable for 34 weeks — the longest-lasting and most refined kidney organoids developed to date.
Nearly a decade ago, the research team became the first to successfully isolate human kidney tissue stem cells — the cells responsible for the organ’s development and growth.
Previous attempts to grow kidneys in a lab using general-purpose stem cells were short-lived, typically lasting only a few weeks and often producing unwanted cell types that compromised research accuracy.
However, this Israeli research team used stem cells taken directly from kidney tissue — cells that naturally develop into kidney parts — allowing them to create a much purer and more stable model with key features found in real kidneys.
This medical breakthrough could have far-reaching implications, redefining the current understanding of kidney diseases and advancing the development of innovative treatments.
Researchers believe the model could help assess how medications impact fetal kidneys during pregnancy and move science closer to repairing or replacing damaged kidney tissue with lab-grown cells.
The discovery came days after researchers from Hebrew University of Jerusalem and international partners discovered a way to boost the immune system’s cancer-fighting ability by reprogramming how T cells, which are white blood cells critical to the immune system, produce energy.
The researchers explained in a study published in the peer-reviewed Nature Communications that disabling a protein known as Ant2 in T cells greatly enhances their effectiveness against tumors.
“By disabling Ant2, we triggered a complete shift in how T cells produce and use energy,” Prof. Michael Berger of Hebrew University’s Faculty of Medicine, who co-led the study with doctorate student Omri Yosef, told the Tazpit Press Service. “This reprogramming made them significantly better at recognizing and killing cancer cells.”
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Netherlands to Push EU to Suspend Israel Trade Deal but Won’t Recognize Palestinian State ‘At This Time’

Netherlands Foreign Affairs Minister Caspar Veldkamp addresses a press conference, in New Delhi on April 1, 2025. Photo: ANI Photo/Sanjay Sharma via Reuters Connect
The Netherlands is spearheading efforts to suspend the European Union-Israel trade agreement amid rising EU criticism of Israel’s actions in Gaza, while simultaneously refusing to recognize a Palestinian state, contrasting with other member states as international pressure mounts.
On Thursday, Dutch Foreign Minister Caspar Veldkamp announced that the Netherlands will push the EU to suspend the trade component of the EU-Israel Association Agreement — a pact governing the EU’s political and economic ties with the Jewish state.
This latest anti-Israel initiative follows a recent EU-commissioned report accusing Israel of committing “indiscriminate attacks … starvation … torture … [and] apartheid” against Palestinians in Gaza during its military campaign against Hamas, an internationally designated terrorist group.
Following calls from a majority of EU member states for a formal investigation, this report built on Belgium’s recent decision to review Israel’s compliance with the trade agreement, a process initiated by the Netherlands and led by EU High Representative for Foreign Affairs and Security Policy Kaja Kallas.
According to the report, “there are indications that Israel would be in breach of its human rights obligations” under the 25-year-old EU-Israel Association Agreement.
While the document acknowledges the reality of violence by Hamas, it states that this issue lies outside its scope — failing to address the Palestinian terrorist group’s role in sparking the current war with its bloody rampage across southern Israel on Oct. 7, 2023.
Israeli officials have slammed the report as factually incorrect and morally flawed, noting that Hamas embeds its military infrastructure within civilian targets and Israel’s army takes extensive precautions to try and avoid civilian casualties.
In a Dutch parliamentary debate on Gaza on Thursday, Veldkamp also announced that the government would not recognize a Palestinian state for now — a position that stands in sharp contrast to the recent moves by several other EU member states to extend recognition.
“The Netherlands is not planning to recognize a Palestinian state at this time,” the Dutch diplomat said.
“This war has ceased to be a just war and is now leading to the erosion of Israel’s own security and identity,” he continued.
This latest decision goes against the position of several EU member states, including France, which has committed to recognizing Palestinian statehood in September.
The United Kingdom has likewise indicated it will do so unless Israel acts to ease the humanitarian crisis in Gaza and agrees to a ceasefire.
For its part, Germany said it was not planning to recognize a Palestinian state in the short term, and Italy argued that recognition must occur simultaneously with the recognition of Israel by the new entity.
Spain, Norway, Ireland, and Slovenia all recognized a Palestinian state last year.
Israel has been facing growing pressure from several EU member states seeking to undermine its defensive campaign against the Palestinian terrorist group Hamas in Gaza.
On Thursday, European Commission Vice President Teresa Ribera strongly condemned Israel’s actions in the war-torn enclave, describing the situation as a “grave violation of human dignity.”
“What we are seeing is a concrete population being targeted, killed and condemned to starve to death,” Ribera told Politico. “If it is not genocide, it looks very much like the definition used to express its meaning.”
Until now, the European Commission has refrained from accusing Israel of genocide, but Ribera’s comments mark one of the strongest European condemnations since the outbreak of the war in Gaza.
She also called on the EU to take decisive action by considering the suspension of its trade agreement with Israel and the implementation of sanctions, while emphasizing that such measures would require unanimous approval from all member states.
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Graduate Student Unions Promoting Antisemitism, Reform Group Says

Students listen to a speech at a protest encampment at Stanford University in Stanford, California US, on April 26, 2024. Photo: Carlos Barria via Reuters Connect.
Higher-education-based unions controlled by United Electrical, Radio, and Machine Workers of America (UE) are rife with antisemitism and anti-Zionist discrimination, according to a new letter imploring the US Congress’s House Committee on Education and the Workforce to address the matter.
“Tracing its roots to communism in the 1930s, the UE is a radical, pro-Hamas labor union that has a long history of antisemitism,” the National Right to Work Foundation (NRTW), one of the US’s leading labor reform groups, wrote on July 30 in a message obtained by The Algemeiner. “The UE openly supports the boycott, divestment, and sanctions (BDS) movement, which is designed to cripple and destroy Israel economically. Today, the UE furthers its antisemitic agenda by unionizing graduate students on college campuses and using its exclusive representation powers to create a hostile environment for Jewish students. The hostile environment includes demanding compulsory dues to fund the UE’s abhorrent activities.”
NRTW went on to describe a litany of alleged injustices to which UE members subject Jewish student-employees in the US’s most prestigious institutions of higher education, from the Massachusetts Institute of Technology (MIT) to Cornell University. At MIT, the letter said, “union officers” aided a riotous group which illegally occupied a section of campus with a “Gaza Solidarity Encampment,” participating in the demonstration and even denying access to campus buildings. UE members at Stanford University, meanwhile, allegedly denied religious accommodations to Jewish students who requested exemption from union dues over that branch’s supporting the BDS movement. And Cornell University UE was accused of denying religious exemptions in several cases as well and followed up the rejection with an intrusive “questionnaire” which probed Jewish students for “legally-irrelevant information.”
The situation requires federal oversight and intervention, NRTW said, including Congress’s possibly clarifying that student-employees are not traditional employees and are therefore afforded protections under sections of the Civil Rights Act which apply to the campus.
“These continuing patterns of antisemitism are illegal, immoral, and must be stopped,” the letter continued. “We encourage you to do all that is in your power to investigate and help bring an end to the UE and its affiliates’ nonstop harassment and intimidation of Jewish students … The Trump administration can also use tools available to it under Title VI and Title VI of the Civil Rights Act against colleges who work with unions to create a hostile environment for Jewish students.”
July’s letter is not the first time NRTW has publicized alleged antisemitic abuse in unions representing higher education employees.
In 2024, it represented a group of six City University of New York (CUNY) professors, five of whom are Jewish, who sued to be “freed” from CUNY’s Professional Staff Congress (PSC-CUNY) over its passing a resolution during Israel’s May 2021 war with Hamas which declared solidarity with Palestinians and accused the Jewish state of ethnic cleansing, apartheid, and crimes against humanity. The group contested New York State’s “Taylor Law,” which it said chained the professors to the union’s “bargaining unit” and denied their right to freedom of speech and association by forcing them to be represented in negotiations by an organization they claim holds antisemitic views.
That same year, NRTW prevailed in a discrimination suit filed to exempt another cohort of Jewish MIT students from paying dues to the Graduate Student Union (GSU). The students had attempted to resist financially supporting GSU’s anti-Zionism, but the union bosses attempted to coerce their compliance, telling them that “no principles, teachings, or tenets of Judaism prohibit membership in or the payment of dues or fees” to the union.
“All Americans should have a right to protect their money from going to union bosses they don’t support, whether those objections are based on religion, politics, or any other reason,” NRTW said at the time.
Follow Dion J. Pierre @DionJPierre.