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The Fall of Assad: A Tectonic Shift in the Middle East

A person gestures next to a burning picture of President Bashar al-Assad, after rebels seized the capital and ousted the president, in Qamishli, Syria, Dec. 8, 2024. Photo: REUTERS/Orhan Qereman
The collapse of Bashar al-Assad’s regime in Syria has sent shockwaves across the Middle East, with experts suggesting it has dismantled Iran’s “ring of fire” strategy and created both opportunities and challenges for Israel.
Prime Minister Benjamin Netanyahu wasted no time in hailing the moment as a “historic” victory for Israeli strategy and security, calling it “a pivotal step toward regional stability and peace.”
“The Assad regime is a central link in Iran’s axis of evil — this regime has fallen,” he said on Sunday.
Speaking during a visit to Mount Bental on Israel’s border with Syria, Netanyahu described the regime’s downfall as the culmination of years of coordinated efforts to counter Iranian influence in Syria. “This is a strategic achievement for Israel, the fruit of our resolute actions against Iran’s entrenchment in the region.”
A Fragmented Syria
The vacuum left by Assad’s downfall has fragmented Syria into competing zones of control. Dina Lisnyansky, an expert in political Islam and terrorism, explained the current dynamics and said there was reason for “cautious optimism.”
“We’re seeing three main factions taking hold: Druze forces in the south, Kurds in the northeast, and Salafi Islamists elsewhere, including parts of Damascus,” she told The Algemeiner.
According to Lisnyansky, this mosaic of power offers Israel a rare diplomatic opening. “This could be an opportunity for Israel to establish relations with individual factions or a new Syrian government.”
However, she cautioned against unbridled optimism against the Salafis, represented by the Hayat Tahrir al-Sham rebel group which led the raid on the Syrian capital of Damascus on Sunday. “The Salafi Islamists remain a branch of al-Qaeda, despite their leader [Abu Mohammed] al-Golani’s rhetoric about good relations with Syria’s neighbors — Jordan, Lebanon, and Israel,” she said. “It’s no coincidence that they received congratulations today from the Taliban, who enthusiastically backed their achievements and the overthrow of Assad.”
Diaspora Affairs Minister Amichai Chikli similarly cautioned Israelis against premature celebrations.
“These are jihadists and Islamists who have done some of the worst things, of the ilk of ISIS and al-Qaeda,” he said, warning that Syria could “look like Afghanistan in no time.”
But, he said, the silver lining was the Kurdish control in the northeast region.
Lisnyansky warned that Turkey’s role in facilitating the overthrow adds another layer of complexity for Israel. Turkey’s growing influence in Syria even carries a potential risk of invasion, Lisnyansky said, referencing Turkish President Recep Tayyip Erdoğan’s threats earlier this year that if Turkey shared a border with Israel, he would have already demonstrated his country’s capabilities, implying retaliation over Israel’s war in Gaza.
“Turkey is, without a doubt, hostile to Israel today. While we very much hope to improve relations with Turkey on one hand, we’re not under any illusions, This means they could currently place forces on our border that might even invade our territory,” she warned.
“We need to proceed with very cautious optimism and understand that what’s happening in the region is still extremely unclear,” she concluded.
Iran’s Setback
The Assad regime’s collapse has struck a significant blow to Iran’s regional ambitions. Assad’s government was a crucial link in Tehran’s efforts to arm and fund terrorist proxies from Lebanon to Gaza, forming a so-called “ring of fire” around Israel. With Damascus now fractured and Iranian proxies weakened, the Islamic Republic’s influence in Syria has been severely undermined.
Issam Zeitoun, a former Syrian opposition figure and founder of the Syrian Peace Initiative, highlighted the importance of regional efforts in this shift. “There is an obvious international and regional decision to keep Iran out,” he said. He credited Israel with playing a central role in curbing Iran’s influence, emphasizing the broader international agreement driving these developments.
Zeitoun also highlighted the humanitarian consequences of the regime’s fall, emphasizing the urgent need to support civilians in southern Syria. “We need to take care of them,” he said.
Zeitoun, speaking to The Algemeiner en route to Israel from Germany — where he fled following the Assad regime’s crackdown — outlined his plans to arrive in Jerusalem to discuss the renewal of the Good Neighbor project, which provided essential supplies and humanitarian aid, including medical treatment, to thousands of Syrians in border communities during the height of the civil war.
During his remarks at Mount Bental, Netanyahu also addressed the program, announcing Israel’s intent to resume it and highlighting its impact, noting that “hundreds of Syrian children were born here in Israel.” At the same time, he reaffirmed Israel’s policy of avoiding direct involvement in Syria’s internal conflicts.
Zeitoun expressed hope for a new era, emphasizing the potential of the Abraham Accords in reshaping regional alliances, and adding that they could potentially include Syria’s new leadership, depending on its trajectory. “We would love to join the Abraham Accords,” he said, referring to a series of US-brokered normalization agreements between Israel and several countries in the Arab world in 2020.
“Everyone is happy. I’m getting calls from everywhere with congratulations. It’s been a very, very bad half-century for Syria,” he said.
“If something happens that we don’t like, we can change it,” he added, expressing confidence that Syrians have learned from the past and will not allow another dictator to take power.
Focus on Israel’s Security
While Netanyahu struck a celebratory tone, he also stressed the importance of vigilance. He gave the order for the Israel Defense Forces to be deployed in the buffer zone between Israel and Syria, he said, marking the first time since the end of the Yom Kippur War in 1973 that Israeli forces have been present in the area for more than a few hours. Israeli forces on Sunday also captured the Syrian side of Mount Hermon.
“We are acting first and foremost to protect our border,” he said. “This area has been controlled for nearly 50 years by a buffer zone agreed upon in 1974, the Separation of Forces Agreement. This agreement has collapsed; the Syrian soldiers have abandoned their positions.”
Nir Boms, chairman of the Syria Research Forum, also struck a cautiously optimistic note, pointing to the potential for renewed cooperation with moderate Syrian groups.
“We’ve seen success in working with opposition figures in the past, particularly in the south. Whether such collaboration can be replicated in this new Syria remains uncertain, but the opportunities are there,” he told The Algemeiner.
“This war is not over yet, but for those who follow the war in Syria and those who see Assad’s downfall as a victory, it is at least a small reason to raise a toast,” he said.
Minorities in the Post-Assad Era
Israeli Maj. Shadi Khalloul (res), an expert on the region and Aramaic Christian activist, emphasized the importance of securing the areas captured by Israel over the weekend. “We will take what we need according to our security needs until there is a safe and different reality,” he told The Algemeiner.
Khalloul reflected on the broader implications for Christians in the region, highlighting their historical suffering under Assad’s regime, which he described as a “vicious enemy” to Israel and to Lebanon’s Aramaic and Maronite communities. Now, with Assad’s fall, communities across Lebanon — including Sunnis, Christians, and Druze — are celebrating, he said.
He noted the significance of Israel’s role in shaping this outcome: “Lebanon and Syria should thank Israel for liberating them, because without Israel this would not have happened today,” he told i24News.
But like the others, Khalloul warned of the risks tied to Syria’s uncertain future, pointing to the potential for instability if secular and Islamist factions fail to reach a power-sharing agreement.
“If these two sections find a deal to divide the power in Syria and rule Syria together, then we will have stability. But if not, we might see a civil war develop between these sides,” he said.
The post The Fall of Assad: A Tectonic Shift in the Middle East first appeared on Algemeiner.com.
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As Gaza War Continues, Hamas Calls for Global Protests While Israel Marks Breakthroughs in Medical Innovation

A pro-Hamas march in London, United Kingdom, Feb. 17, 2024. Photo: Chrissa Giannakoudi via Reuters Connect
As the Palestinian terrorist group Hamas calls for global protests amid stalled Gaza ceasefire talks, Israel has broken new ground despite the ongoing conflict, achieving a major medical breakthrough in synthetic human kidney development.
The contrast illustrates a stark contrast between the priorities of Hamas, an international designated terrorist group that has ruled Gaza for nearly two decades, and Israel, the lone democracy in the Middle East that has long been a leader in tech and medical innovation.
On Wednesday, Hamas urged worldwide protests in support of Palestinians, calling on the international community “to denounce Israel’s genocidal war and starvation policy in Gaza.”
“We call for continuing and escalating the popular pressure in all cities and squares on Friday, Saturday, and Sunday … through rallies, demonstrations and sit-ins outside the embassies of the Israeli regime and its allies, particularly in the US,” the statement read.
The Palestinian terrorist group also called to expose what it described as “the terrorism of the Zio-Nazi occupation against defenseless civilians.”
Hamas’s latest move against Israel comes amid stalled indirect negotiations over a proposed 60-day ceasefire and hostage release deal, which collapsed last month after the group vowed it would not disarm unless an independent Palestinian state is established — rejecting a key Israeli demand to end the war in Gaza.
In its statement, Hamas demanded the opening of all border crossings to allow immediate aid into the war-torn enclave and urged a global condemnation of “the international community’s inaction on the Israeli crimes.”
Amid mounting international pressure to address the humanitarian crisis in Gaza, Israel announced new measures to facilitate the delivery of aid, including temporary pauses in fighting in certain areas and the creation of protected routes for aid convoys.
Israeli officials have previously accused Hamas of diverting aid for terrorist activities and selling supplies at inflated prices to civilians, while also blaming the United Nations and other foreign organizations for enabling this diversion.
Hamas’s statement also emphasized that the “global resistance movement must continue until Israeli aggression on Gaza ends and the siege on the coastal strip is lifted.”
Meanwhile, as Israel faces escalating hostilities and the heavy toll of war, the Jewish state continues to push the boundaries of innovation and resilience, achieving new medical breakthroughs while confronting ongoing challenges.
In a major medical breakthrough, scientists at Sheba Medical Center and Tel Aviv University have successfully grown a synthetic 3D miniature human kidney in a lab using specialized stem cells derived from kidney tissue — one of the most promising advances in regenerative medicine.
Dr. Dror Harats, chairman of Sheba’s Research Authority, described this achievement as a reflection of Israel’s leading role in global medical innovation.
“Despite growing efforts to isolate Israel from international science, breakthroughs like this prove our impact is both lasting and essential,” he said.
In a landmark study, a team from Sheba’s Safra Children’s Hospital and Tel Aviv University’s Sagol Center for Regenerative Medicine created synthetic kidney organs that matured and remained stable for 34 weeks — the longest-lasting and most refined kidney organoids developed to date.
Nearly a decade ago, the research team became the first to successfully isolate human kidney tissue stem cells — the cells responsible for the organ’s development and growth.
Previous attempts to grow kidneys in a lab using general-purpose stem cells were short-lived, typically lasting only a few weeks and often producing unwanted cell types that compromised research accuracy.
However, this Israeli research team used stem cells taken directly from kidney tissue — cells that naturally develop into kidney parts — allowing them to create a much purer and more stable model with key features found in real kidneys.
This medical breakthrough could have far-reaching implications, redefining the current understanding of kidney diseases and advancing the development of innovative treatments.
Researchers believe the model could help assess how medications impact fetal kidneys during pregnancy and move science closer to repairing or replacing damaged kidney tissue with lab-grown cells.
The discovery came days after researchers from Hebrew University of Jerusalem and international partners discovered a way to boost the immune system’s cancer-fighting ability by reprogramming how T cells, which are white blood cells critical to the immune system, produce energy.
The researchers explained in a study published in the peer-reviewed Nature Communications that disabling a protein known as Ant2 in T cells greatly enhances their effectiveness against tumors.
“By disabling Ant2, we triggered a complete shift in how T cells produce and use energy,” Prof. Michael Berger of Hebrew University’s Faculty of Medicine, who co-led the study with doctorate student Omri Yosef, told the Tazpit Press Service. “This reprogramming made them significantly better at recognizing and killing cancer cells.”
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Netherlands to Push EU to Suspend Israel Trade Deal but Won’t Recognize Palestinian State ‘At This Time’

Netherlands Foreign Affairs Minister Caspar Veldkamp addresses a press conference, in New Delhi on April 1, 2025. Photo: ANI Photo/Sanjay Sharma via Reuters Connect
The Netherlands is spearheading efforts to suspend the European Union-Israel trade agreement amid rising EU criticism of Israel’s actions in Gaza, while simultaneously refusing to recognize a Palestinian state, contrasting with other member states as international pressure mounts.
On Thursday, Dutch Foreign Minister Caspar Veldkamp announced that the Netherlands will push the EU to suspend the trade component of the EU-Israel Association Agreement — a pact governing the EU’s political and economic ties with the Jewish state.
This latest anti-Israel initiative follows a recent EU-commissioned report accusing Israel of committing “indiscriminate attacks … starvation … torture … [and] apartheid” against Palestinians in Gaza during its military campaign against Hamas, an internationally designated terrorist group.
Following calls from a majority of EU member states for a formal investigation, this report built on Belgium’s recent decision to review Israel’s compliance with the trade agreement, a process initiated by the Netherlands and led by EU High Representative for Foreign Affairs and Security Policy Kaja Kallas.
According to the report, “there are indications that Israel would be in breach of its human rights obligations” under the 25-year-old EU-Israel Association Agreement.
While the document acknowledges the reality of violence by Hamas, it states that this issue lies outside its scope — failing to address the Palestinian terrorist group’s role in sparking the current war with its bloody rampage across southern Israel on Oct. 7, 2023.
Israeli officials have slammed the report as factually incorrect and morally flawed, noting that Hamas embeds its military infrastructure within civilian targets and Israel’s army takes extensive precautions to try and avoid civilian casualties.
In a Dutch parliamentary debate on Gaza on Thursday, Veldkamp also announced that the government would not recognize a Palestinian state for now — a position that stands in sharp contrast to the recent moves by several other EU member states to extend recognition.
“The Netherlands is not planning to recognize a Palestinian state at this time,” the Dutch diplomat said.
“This war has ceased to be a just war and is now leading to the erosion of Israel’s own security and identity,” he continued.
This latest decision goes against the position of several EU member states, including France, which has committed to recognizing Palestinian statehood in September.
The United Kingdom has likewise indicated it will do so unless Israel acts to ease the humanitarian crisis in Gaza and agrees to a ceasefire.
For its part, Germany said it was not planning to recognize a Palestinian state in the short term, and Italy argued that recognition must occur simultaneously with the recognition of Israel by the new entity.
Spain, Norway, Ireland, and Slovenia all recognized a Palestinian state last year.
Israel has been facing growing pressure from several EU member states seeking to undermine its defensive campaign against the Palestinian terrorist group Hamas in Gaza.
On Thursday, European Commission Vice President Teresa Ribera strongly condemned Israel’s actions in the war-torn enclave, describing the situation as a “grave violation of human dignity.”
“What we are seeing is a concrete population being targeted, killed and condemned to starve to death,” Ribera told Politico. “If it is not genocide, it looks very much like the definition used to express its meaning.”
Until now, the European Commission has refrained from accusing Israel of genocide, but Ribera’s comments mark one of the strongest European condemnations since the outbreak of the war in Gaza.
She also called on the EU to take decisive action by considering the suspension of its trade agreement with Israel and the implementation of sanctions, while emphasizing that such measures would require unanimous approval from all member states.
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Graduate Student Unions Promoting Antisemitism, Reform Group Says

Students listen to a speech at a protest encampment at Stanford University in Stanford, California US, on April 26, 2024. Photo: Carlos Barria via Reuters Connect.
Higher-education-based unions controlled by United Electrical, Radio, and Machine Workers of America (UE) are rife with antisemitism and anti-Zionist discrimination, according to a new letter imploring the US Congress’s House Committee on Education and the Workforce to address the matter.
“Tracing its roots to communism in the 1930s, the UE is a radical, pro-Hamas labor union that has a long history of antisemitism,” the National Right to Work Foundation (NRTW), one of the US’s leading labor reform groups, wrote on July 30 in a message obtained by The Algemeiner. “The UE openly supports the boycott, divestment, and sanctions (BDS) movement, which is designed to cripple and destroy Israel economically. Today, the UE furthers its antisemitic agenda by unionizing graduate students on college campuses and using its exclusive representation powers to create a hostile environment for Jewish students. The hostile environment includes demanding compulsory dues to fund the UE’s abhorrent activities.”
NRTW went on to describe a litany of alleged injustices to which UE members subject Jewish student-employees in the US’s most prestigious institutions of higher education, from the Massachusetts Institute of Technology (MIT) to Cornell University. At MIT, the letter said, “union officers” aided a riotous group which illegally occupied a section of campus with a “Gaza Solidarity Encampment,” participating in the demonstration and even denying access to campus buildings. UE members at Stanford University, meanwhile, allegedly denied religious accommodations to Jewish students who requested exemption from union dues over that branch’s supporting the BDS movement. And Cornell University UE was accused of denying religious exemptions in several cases as well and followed up the rejection with an intrusive “questionnaire” which probed Jewish students for “legally-irrelevant information.”
The situation requires federal oversight and intervention, NRTW said, including Congress’s possibly clarifying that student-employees are not traditional employees and are therefore afforded protections under sections of the Civil Rights Act which apply to the campus.
“These continuing patterns of antisemitism are illegal, immoral, and must be stopped,” the letter continued. “We encourage you to do all that is in your power to investigate and help bring an end to the UE and its affiliates’ nonstop harassment and intimidation of Jewish students … The Trump administration can also use tools available to it under Title VI and Title VI of the Civil Rights Act against colleges who work with unions to create a hostile environment for Jewish students.”
July’s letter is not the first time NRTW has publicized alleged antisemitic abuse in unions representing higher education employees.
In 2024, it represented a group of six City University of New York (CUNY) professors, five of whom are Jewish, who sued to be “freed” from CUNY’s Professional Staff Congress (PSC-CUNY) over its passing a resolution during Israel’s May 2021 war with Hamas which declared solidarity with Palestinians and accused the Jewish state of ethnic cleansing, apartheid, and crimes against humanity. The group contested New York State’s “Taylor Law,” which it said chained the professors to the union’s “bargaining unit” and denied their right to freedom of speech and association by forcing them to be represented in negotiations by an organization they claim holds antisemitic views.
That same year, NRTW prevailed in a discrimination suit filed to exempt another cohort of Jewish MIT students from paying dues to the Graduate Student Union (GSU). The students had attempted to resist financially supporting GSU’s anti-Zionism, but the union bosses attempted to coerce their compliance, telling them that “no principles, teachings, or tenets of Judaism prohibit membership in or the payment of dues or fees” to the union.
“All Americans should have a right to protect their money from going to union bosses they don’t support, whether those objections are based on religion, politics, or any other reason,” NRTW said at the time.
Follow Dion J. Pierre @DionJPierre.