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A German town built a granary atop its Jewish cemetery. Now the bones are yielding insights about Ashkenazi DNA.
BERLIN (JTA) – The city of Erfurt in central Germany is home to an impeccably restored medieval synagogue made possible because local Jews had been expelled long before the Nazis began their campaign to destroy Jewish sites.
Now, Erfurt’s long-hidden Jewish past is again offering new insights — this time about the genetic history of Ashkenazi Jews.
Human remains from a medieval Jewish cemetery in Erfurt have allowed what researchers say is the largest ancient Jewish DNA study to date. Conducted without disinterring any remains, in keeping with Jewish law, the study published Wednesday in the scientific journal Cell found that Erfurt’s medieval Jewish community was more genetically diverse than their modern-day cousins, and carried many of the same Jewish genetic diseases — such as Tay Sachs and cystic fibrosis — that affect Ashkenazi Jews today.
“There have been many previous DNA studies, but not of Jews,” said geneticist Shai Carmi, a professor at the Hebrew University of Jerusalem, whose search for study material led him to an archaeological dig at the Jewish cemetery in Erfurt. He and his collaborators were able to analyze DNA of 33 individuals who died between 1270 and 1400, using teeth they found there.
The study follows a similar analysis revealed in August by researchers in England, who studied the DNA from skeletons found at the bottom of a medieval well and concluded that the remains were likely of victims of an antisemitic massacre in 1190. Analysis of six individuals prior to their identification as Jewish revealed that Ashkenazi Jews developed a unique genetic variation centuries earlier than realized.
The Erfurt analysis also includes samples from before the epidemic of Black Death that was until recently understood to have created the genetic “bottleneck” that created the genetic markers common among Ashkenazi Jews today.
Erfurt’s Jewish settlement existed from the 11th to 15th century, with a brief gap following a 1349 massacre perpetrated after the Jews were falsely blamed for causing the bubonic plague. Surviving Jews returned there, but after all Jews were expelled once and for all in 1454, the city built a granary on top of the Jewish cemetery.
Karin Sczech participates in the excavation at the medieval Jewish cemetery of Erfurt. (Courtesy of TLDA Ronny Krause)
In 2013, the city approved the repurposing of the unused granary into a parking lot. Because it was an historic site, a rescue excavation was initiated, overseen for the State of Thuringia by German archaeologist Karin Sczech.
Meanwhile, Carmi had been looking for Jewish cemeteries anywhere in the world “where we could analyze remains already excavated,” he told JTA in a telephone interview from Jerusalem. “I consulted historians and eventually reached the archeologist in Erfurt.” Fortunately, he said, “they still hadn’t reburied the remains.”
He approached Sczech, who later became a co-author of the new study. In 2018, with a supportive judgment from Rabbi Ze’ev Litke — an Israeli expert on genetics and Jewish law — and permission from Erfurt’s then-rabbi, Benjamin Kochan, work began to extract and analyze DNA from detached teeth found in the graves. (About 500 Jews live in Erfurt today, most of them having migrated from the former Soviet Union since 1990.)
American geneticist David Reich picked up the teeth and brought them back to the department of human evolutionary biology at Harvard University in Cambridge, Massachusetts, where drilling and DNA extraction took place.
While the skeletons were reburied, the teeth are still stored at the research institutes where they have been analyzed, in case scientists need to retest to verify the result.
The project provides an ethical basis for studies of ancient Jewish DNA, Carmi said. “Of course we couldn’t just go to a cemetery and dig and take out skeletons; this would be prohibited,” he said, referring to Jewish law prohibiting the removal of bones from where someone was buried.
But Litke opined that the study could be done, because the bones already had been disturbed for an unrelated reason. “He recommended using teeth, as the analysis does almost no damage,” Carmi said.
There are many motivations to study Jewish DNA: One can find lost relatives going back a few generations, and answer questions about Jewish origin of partners intending to marry. But the goal of Carmi’s team was “to fill the gaps in our understanding of Ashkenazi Jewish early history.”
There are several non-destructive ways to obtain DNA from human remains, said Carmi, who also works as a consultant to an Israeli firm that helps clients trace their genetic roots.
“You can take an almost microscopic slice of bone and extract DNA in a solution, or put the entire bone in a solution and extract the DNA without drilling, without disturbing the dead. This opens the way to doing studies even without teeth,” he added.
His team found that the Erfurt community appeared to fit into two genetically distinct groups, descending either from Middle Eastern or European populations. This genetic variability no longer exists, Carmi said.
At the same time, Carmi said, the analysis found remarkable continuity in the local community, as well. “One third of the Erfurt individuals descended from one woman through their maternal lines,” he said, adding that evidence suggested that she lived between 1,000 and 2,000 years ago.
In a press statement, geneticist Reich of Harvard said the work “also provides a template for how a co-analysis of modern and ancient DNA data can shed light on the past. Studies like this hold great promise not only for understanding Jewish history, but also that of any population.”
The research team, with more than 30 scientists, included Hebrew University’s Shamam Waldman, a doctoral student in Carmi’s group, who performed most of the data analysis.
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US-Israeli Attack Triggers Fear and Panic in Iran
Buildings stand, after Israel and the US launched strikes on Iran, in Tehran, Iran, February 28, 2026. Photo: Majid Asgaripour/WANA (West Asia News Agency) via REUTERS
Iranians fled cities in search of safety, and long queues formed at fuel stations as an attack on Iran by the United States and Israel spread fear and panic throughout the country.
When the strikes began on Saturday morning, explosions rocked Tehran and columns of smoke rose into the sky, shaking the city at the start of the Iranian working week.
Residents reached by phone described scenes of chaos and alarm as they rushed to collect their children from school or made preparations to leave home for now.
“We are going to our hometown in Yazd, Tehran is not safe anymore. They said roads are safe, but I am worried,” said Gholamreza, a Tehran shopkeeper and father of two. “I am leaving everything behind in Tehran.”
It marks the latest upheaval for Iranians weeks after thousands of people were killed in a government crackdown on nationwide unrest, and comes just eight months after last year’s 12-day war with Israel, during which the United States bombed Iranian nuclear sites.
Iran’s top security body said it expected attacks to continue on Tehran and some other cities, and urged people to “travel to other cities where possible so that you may remain safe from the harm of these two regimes’ acts of aggression.” Schools and universities would be closed until further notice.
“We are scared, we are terrified. My children are shaking, we have nowhere to go, we will die here,” said Minou, a 32-year-old mother of two from the northern city of Tabriz, one of many areas where explosions were reported.
“What is going to happen to my children?” she said, crying as she spoke by phone.
US President Donald Trump said the operation would end a security threat to the United States and offer Iranians a chance to topple their rulers. The Pentagon said that US strikes against Iran were named “OPERATION EPIC FURY.”
An Iranian from the central city of Yazd said he hoped the attack would topple the clerical establishment that has run the country since the 1979 Islamic Revolution. “Let them bomb,” the resident of Yazd said.
Samira Mohebbi, speaking from the northern city of Rasht, disagreed.
“I am against this regime, to hell with them. But I don’t want my country to be attacked by foreign forces, I don’t want my Iran to turn into Iraq,” she said, referring to the neighboring country that suffered years of chaos and bloodshed following the U.S.-led invasion that toppled Saddam Hussein.
‘THEY FOOLED US AGAIN’
Security forces blocked roads in the area of Tehran that is home to the offices of Supreme Leader Ayatollah Ali Khamenei, President Masoud Pezeshkian and parliament, witnesses said.
The latest round of negotiations between the United States and Iran in Geneva on Thursday failed to secure a breakthrough over Tehran’s nuclear programme, though Omani mediators reported progress.
“They said the nuclear talks are going well. They fooled us again,” said a resident of Tehran.
Zohreh, 28, said she would leave the port city of Bushehr with her three-year-old daughter and go to her parents’ home in a village in northern Iran.
“Why are we paying this price? I want my daughter to grow up safe and in peace,” she said.
Western governments have long suspected Iran aims to build a nuclear bomb. Tehran has always denied this.
Witnesses said people were rushing to buy hard currency.
In Isfahan, another area where attacks were reported, some said they were unable to withdraw cash from ATMs.
Reza Saadati, 45, said he was taking his family to the city of Urumieh near the Turkish border. “If the border is open, we will cross and then fly to Istanbul,” he said.
Mohammad Esmaili, 63, speaking from the town of Ilam, some 500 km (300 miles) from Tehran, said he would leave the town with his family. “God knows what will happen to us. Pray for us,” he said.
“People are shocked, scared. What is going to happen to us? Save us please,” said a woman from Tehran.
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Prior to Iran attacks, CIA assessed Khamenei Would Be Replaced by IRCG Elements if Killed
Members of the Islamic Revolutionary Guard Corps (IRGC) attend an IRGC ground forces military drill in the Aras area, East Azerbaijan province, Iran, Oct. 17, 2022. Photo: IRGC/WANA (West Asia News Agency)/Handout via REUTERS
In the run-up to the US and Israeli attacks on Saturday, the US Central Intelligence Agency assessed that even if Iran’s Supreme Leader Ayatollah Ali Khamenei was killed in the operation, he would likely be replaced by hardline figures from the Islamic Revolutionary Guard Corps (IRGC), two sources briefed on the intelligence said.
The assessments, which were produced over the past two weeks, looked broadly at what could occur in Iran following a US intervention and the extent to which a military operation could trigger regime change in the Islamic Republic — now a pronounced objective for Washington.
The IRGC is an elite military force whose purpose is to protect Shi’ite Muslim clerical rule in Iran.
The intelligence agency reports did not conclude any scenario with certainty, said the sources, who spoke on condition of anonymity to discuss intelligence matters.
The Central Intelligence Agency declined to comment.
President Donald Trump has for weeks signaled the US was interested in seeing regime change in Iran, but has not given in any detail Washington’s thinking on who could lead the country.
In an early morning video address on Saturday, Trump described Tehran as a “terrorist regime” and encouraged the Iranian people to take over the government, saying the US military strikes would set the stage for an uprising.
The US and Israeli assault comes after weeks of deliberation inside the US government about whether to strike Iran following the deadly protests that broke out there in December.
US officials in recent weeks have tried to strike a nuclear deal with Tehran in an attempt to stave off intervention.
In a briefing last week, Secretary of State Marco Rubio told top congressional lawmakers known as the Gang of Eight that a US operation would likely move forward, but that Trump could change his mind, particularly if nuclear negotiations were successful. Those talks in Geneva did not result in an agreement.
Rubio notified the Gang of Eight on Friday night that the operation to attack Iran was likely to commence in the following hours but said Trump could still change his mind, two sources familiar with the matter said.
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US and Israel Launched Military Operation Against Islamic Republic: This Is What We Know So Far
Iranian mourners wave the country’s flags while participating in a memorial ceremony for IRGC commanders, nuclear scientists, and civilians killed in the Iran-Israel war at the Imam Khomeini Grand Mosque in downtown Tehran, Iran, on July 2, 2025. Photo: Morteza Nikoubazl via Reuters Connect.
i24 News – It’s been just over ten hours since the US and Israel launched operations “Epic Fury” and “Roaring Lion” against the Islamic Republic. And while this is still a developing story, here is what we know.
Just after 8 am local time the US and Israel launched a series of strikes on Iranian military targets across Iran. The main targets were Iran’s leaders and IRGC senior commanders in Iran and some targets in Iraq.
The IDF says it struck hundreds of targets, including ready-to-fire ballistic missile launchers. While there is no official confirmation of any specific eliminations, Iran’s foreign minister confirmed that some senior commanders were eliminated.
As Israeli and US strikes continued, Iran launched numerous ballistic missile barrages across Israel, and against six Arab countries, namely Saudi Arabia, the UAE, Qatar, Jordan, Kuwait and Bahrain, who all condemned the Iranian strikes on their territory. Iran claims it targeted US military bases in the region.
The escalation also saw a rare sign of unity between Riyadh and Abu Dhabi, who have suffered from tense relations in recent weeks.
Iran has vowed to continue its strikes across the region, with Israeli officials saying they expect the strikes against Iran to continue for at least a few days.
While Iran has already turned this into a regional conflict, it still has potential to expand further. So far, neither Hezbollah in Lebanon nor Pro-Iranian militias in Iraq have joined the fray.
Lebanese Prime Minister Nawaf Salam sent a warning message to Hezbollah not to drag the country into, quote, “adventures that threaten its security and unity.”