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Raphael Mechoulam, Israel’s ‘father of cannabis research,’ dies at 92
(JTA) — In the early 1960s, a Bulgarian-born scientist named Raphael Mechoulam was caught carrying five kilograms of, as he called it, “superb, smuggled Lebanese hashish” on a bus from Tel Aviv to Rehovot. But he wasn’t planning on smoking the stuff.
Mechoulam was a fledgling researcher keen on exploring the science behind cannabis, a stigmatized plant whose specific medical properties were not yet known. Over the decades he became a pioneer in cannabis research, whose findings about the psychoactive substance helped ease its entry out of the counterculture and into the mainstream.
Mechoulam died in Israel at age 92; his death was announced Friday by American Friends of the Hebrew University, where Mechoulam helped form The Hebrew University Multidisciplinary Center for Cannabinoid Research in 2017.
“Most of the human and scientific knowledge about cannabis was accumulated thanks to Prof. Mechoulam,” Hebrew University President Asher Cohen said in a statement. “He paved the way for groundbreaking studies and initiated scientific cooperation between researchers around the world. Mechoulam was a sharp-minded and charismatic pioneer.”
As a professor in the Hebrew University School of Pharmacy, Mechoulam and his research team isolated THC, the psychoactive component of cannabis, as well as cannabidiol, or CBD, an active ingredient in cannabis with a range of medicinal benefits.
He also pioneered the study of the body’s own cannabinoid system, which produces chemicals similar to THC to help regulate appetite, manage pain and operate the immune system.
As Mechoulam discovered more about cannabis and its efficacy in easing symptoms of cancer, epilepsy and other diseases, he lamented that strict drug laws in the United States and elsewhere suppressed research and kept the derivatives of cannabis off the market.
“Medicinal cannabis has to follow medical lines of thought and development and modern medical routes” in order to be part of proper drugs, he told the New York Times in 2017. “Israel has more [clinical trials] than the United States at the moment, which is ridiculous.”
Mechoulam was a founding member of the International Association for Cannabinoid Medicines and the International Cannabinoid Research Society. In 1994, he was elected to be a member of the Israel Academy of Sciences and Humanities.
Mechoulam was born in Bulgaria in 1930 and immigrated in 1949 with his family to Israel, where he later studied chemistry. He received his PhD at the Weizmann Institute in Rehovot, writing a thesis on the chemistry of steroids. After postdoctoral studies at the Rockefeller Institute in New York, he joined the scientific staff of the Weizmann Institute.
Mechoulam became a full professor at Hebrew University in 1972 and was named the Lionel Jacobson Professor of Medicinal Chemistry in 1975, serving as the university’s rector from 1979-1982.
In 2022, the YIVO Institute for Jewish Research in New York City mounted its exhibition on Jewish contributions to the history of cannabis and highlighted the work of Mechoulam. “He’s worked on cannabis his entire life, and in the 1990s he and his colleagues discovered the endocannabinoid system, which regulates homeostasis — a significant discovery on how the human body deals with cannabinoids,” Eddy Portnoy, who curated the exhibit, told the Jewish Telegraphic Agency at the time. “I read an interview with him where he says that because he was in a small country, he would have to find a niche that other people weren’t working in.”
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Turkey’s Fidan: Gaza Governance Must Precede Hamas Disarmament in Ceasefire Deal
Turkish Foreign Minister Hakan Fidan attends a press conference following a meeting with Russian Foreign Minister Sergei Lavrov in Moscow, Russia, May 27, 2025. Photo: Pavel Bednyakov/Pool via REUTERS
Turkish Foreign Minister Hakan Fidan told Reuters on Saturday that not advancing the US-backed Gaza ceasefire plan to its next stage would be a “huge failure” for the world and Washington, noting that President Donald Trump had personally led the push.
In an interview on the sidelines of the Doha Forum, Fidan said a credible Palestinian civil administration and a vetted, trained police force needed to be in place to allow Hamas to disarm, and that the group was prepared to hand over control of the enclave.
“First of all, we need to see that the Palestinian committee of technical people are taking over the administration of Gaza, then we need to see that the police force is being formed to police Gaza – again, by the Palestinians, not Hamas.”
NATO member Turkey has been one of the most vocal critics of Israel’s assault on Gaza. It played a key role in brokering the ceasefire deal, signing the agreement as a guarantor. It has repeatedly expressed its willingness to join efforts to monitor the accord’s implementation, a move Israel strongly opposes.
Talks to advance the next phase of President Trump’s plan to end the two-year conflict in Gaza are continuing.
The plan envisages an interim technocratic Palestinian administration in the enclave, overseen by an international “board of peace” and supported by a multinational security force. Negotiations over the composition and mandate of that force have proven particularly difficult.
Fidan said the Gaza police force would be backed by the international stabilisation force. He added that Washington was pressing Israel over Turkey’s bid to join the force, to which it has voiced readiness to deploy troops if needed.
FIDAN SAYS KURDISH SDF IN SYRIA NOT WILLING TO INTEGRATE
Asked about a landmark deal in March in which the Kurdish-led Syrian Democratic Forces and Damascus agreed that the SDF would be integrated into Syria’s state structures, Fidan said signals from the SDF showed it had “no intention” of honouring the accord, and was instead seeking to sidestep it.
Ankara, which considers the SDF a terrorist organisation, has threatened military action if it does not comply, setting a deadline of the end of the year.
“I think they (SDF) should understand that the command and control should come from one place,” Fidan added. “There can be no two armies in any given country. So there can only be one army, one command structure … But in local administration, they can reach a different settlement and different understandings.”
Almost a year after the fall of president Bashar al-Assad, Fidan said some issues of minority rights were unresolved, insisting that Turkey’s backing of the new Syrian government was not a “blank cheque” to oppress any groups.
He said Damascus was taking steps toward national unity, but that Israeli “destabilisation policies” were the chief obstacle.
Israel has frequently struck southwestern Syria this year, citing threats from militant groups and the need to protect the Druze community near the frontier. Prime Minister Benjamin Netanyahu said on Tuesday he expected Syria to establish a demilitarised buffer zone from Damascus to the border.
TURKEY: U.S. COULD REMOVE SANCTIONS ‘VERY SOON’
Fidan also said Washington’s initial 28-point plan to end the Russia-Ukraine war was just a “starting point,” and that it was now evolving in a new format. He said mediation by US officials was “on the right path.”
“I just hope that nobody leaves the table and the Americans are not frustrated, because sometimes the mediators can be frustrated if they don’t see enough encouragement from both sides.”
Asked about efforts to lift US sanctions imposed in 2020 over Ankara’s purchase of Russian S-400 air defense systems, he said both sides were working on it, adding: “I believe we’ll soon find a way to remove that obstacle.”
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German-Israeli Ties Are on the Upward Trend, Says FM Sa’ar Welcoming Chancellor Merz on First State Visit
German Chancellor Friedrich Merz attends celebrations of the newly completed renovation of Reichenbach Strasse synagogue in Munich, Germany, Sept. 15, 2025. Photo: REUTERS/Angelika Warmuth
i24 News – German Chancellor Friedrich Merz landed in Israel on Saturday for his first visit since taking office, aiming to reaffirm traditionally solid ties that took a hit during the Gaza war.
“Relations between the countries are on an upward trend,” Israeli Foreign Minister Gideon Sa’ar pointed out welcoming Merz at the Ben Gurion airport.
The ties were shaken during the Gaza war set off by the October 7, 2023 Hamas-led massacre, the deadliest antisemitic atrocity since the Holocaust. Merz, who took office in May this year, has repeatedly criticized Israel’s military campaign.
“This trend is reflected in the removal of the partial embargo, Germany’s clear opposition to all types of boycotts against Israel, and its abstention at the UN from supporting the extension of UNRWA’s mandate. Last week, an Israeli Arrow battery for defense against ballistic missiles was deployed in Germany for the first time,” Sa’ar further added.
The $4.5 billion deal represents the largest arms export agreement in Israeli history, and Berlin has also turned to Israeli firms for help in drone defense.
“Germany is an important friend, and I am convinced that the Chancellor’s visit will contribute to the strengthening of the special relations between the countries.”
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Gaza Talks at Critical Moment, Ceasefire Not Complete, Qatar’s Prime Minister Says
Qatar’s Prime Minister and Minister for Foreign Affairs Sheikh Mohammed bin Abdulrahman bin Jassim Al-Thani speaks on the first day of the 23rd edition of the annual Doha Forum, in Doha, Qatar, December 6, 2025. Photo: REUTERS/Ibraheem Abu Mustafa
Negotiations on consolidating the US-backed truce in the war in Gaza are at a “critical” moment, Qatari Prime Minister Sheikh Mohammed bin Abdulrahman al-Thani said on Saturday.
Mediators are working to force the next phase of the ceasefire forward, al-Thani, whose country has been a key mediator in the war, said during a panel discussion at the Doha Forum conference in Qatar.
Violence has subsided but not stopped since the Gaza truce took effect on October 10, and at least seven people were reported killed on Saturday.
“We are at a critical moment. It’s not yet there. So what we have just done is a pause,” al-Thani said.
“We cannot consider it yet a ceasefire. A ceasefire cannot be completed unless there is a full withdrawal of the Israeli forces – (until) there is stability back in Gaza, people can go in and out – which is not the case today.”
TALKS ON INTERNATIONAL SECURITY FORCE
Negotiations on the next stages of US President Donald Trump’s plan to end the two-year war in the Palestinian enclave have been continuing.
On Thursday, an Israeli delegation held talks in Cairo with mediators on the return of the last hostage held in Gaza, which would complete an initial part of Trump’s plan.
Since the truce started, Hamas has returned all 20 living hostages and 27 bodies in exchange for around 2,000 Palestinian detainees and convicted prisoners.
Israel said this week it would open the Rafah Crossing for exit through Egypt soon, and that it would allow entry through Rafah into Gaza once the last remaining deceased hostage was returned.
Trump’s plan calls for an interim technocratic Palestinian government in Gaza, overseen by an international “board of peace” and backed by an international security force. Agreeing on the makeup and mandate of that force has been particularly challenging.
Although fighting has diminished, Israel has continued to attack Gaza and demolish what it says is Hamas infrastructure. Hamas and Israel have traded blame for violations.
The Israeli military said that in two separate incidents on Saturday, forces deployed in northern Gaza behind the so-called yellow line of withdrawal agreed in the ceasefire had fired on Palestinian terrorists who crossed the line, killing three.
The military was unaware of any drone strike, a spokesperson said.