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Raphael Mechoulam, Israel’s ‘father of cannabis research,’ dies at 92
(JTA) — In the early 1960s, a Bulgarian-born scientist named Raphael Mechoulam was caught carrying five kilograms of, as he called it, “superb, smuggled Lebanese hashish” on a bus from Tel Aviv to Rehovot. But he wasn’t planning on smoking the stuff.
Mechoulam was a fledgling researcher keen on exploring the science behind cannabis, a stigmatized plant whose specific medical properties were not yet known. Over the decades he became a pioneer in cannabis research, whose findings about the psychoactive substance helped ease its entry out of the counterculture and into the mainstream.
Mechoulam died in Israel at age 92; his death was announced Friday by American Friends of the Hebrew University, where Mechoulam helped form The Hebrew University Multidisciplinary Center for Cannabinoid Research in 2017.
“Most of the human and scientific knowledge about cannabis was accumulated thanks to Prof. Mechoulam,” Hebrew University President Asher Cohen said in a statement. “He paved the way for groundbreaking studies and initiated scientific cooperation between researchers around the world. Mechoulam was a sharp-minded and charismatic pioneer.”
As a professor in the Hebrew University School of Pharmacy, Mechoulam and his research team isolated THC, the psychoactive component of cannabis, as well as cannabidiol, or CBD, an active ingredient in cannabis with a range of medicinal benefits.
He also pioneered the study of the body’s own cannabinoid system, which produces chemicals similar to THC to help regulate appetite, manage pain and operate the immune system.
As Mechoulam discovered more about cannabis and its efficacy in easing symptoms of cancer, epilepsy and other diseases, he lamented that strict drug laws in the United States and elsewhere suppressed research and kept the derivatives of cannabis off the market.
“Medicinal cannabis has to follow medical lines of thought and development and modern medical routes” in order to be part of proper drugs, he told the New York Times in 2017. “Israel has more [clinical trials] than the United States at the moment, which is ridiculous.”
Mechoulam was a founding member of the International Association for Cannabinoid Medicines and the International Cannabinoid Research Society. In 1994, he was elected to be a member of the Israel Academy of Sciences and Humanities.
Mechoulam was born in Bulgaria in 1930 and immigrated in 1949 with his family to Israel, where he later studied chemistry. He received his PhD at the Weizmann Institute in Rehovot, writing a thesis on the chemistry of steroids. After postdoctoral studies at the Rockefeller Institute in New York, he joined the scientific staff of the Weizmann Institute.
Mechoulam became a full professor at Hebrew University in 1972 and was named the Lionel Jacobson Professor of Medicinal Chemistry in 1975, serving as the university’s rector from 1979-1982.
In 2022, the YIVO Institute for Jewish Research in New York City mounted its exhibition on Jewish contributions to the history of cannabis and highlighted the work of Mechoulam. “He’s worked on cannabis his entire life, and in the 1990s he and his colleagues discovered the endocannabinoid system, which regulates homeostasis — a significant discovery on how the human body deals with cannabinoids,” Eddy Portnoy, who curated the exhibit, told the Jewish Telegraphic Agency at the time. “I read an interview with him where he says that because he was in a small country, he would have to find a niche that other people weren’t working in.”
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High-Stakes US Special Forces Mission Rescues Airman From Iran After F-15 Crash
FILE PHOTO: A U.S. Air Force F-15E Strike Eagle aircraft takes off for a mission supporting Operation Epic Fury during the Iran war at an undisclosed location, March 9, 2026. U.S. Air Force/Handout via REUTERS/File Photo
US forces staged the audacious rescue of an airman behind enemy lines after Iran downed his fighter jet, officials said on Sunday, resolving a crisis for President Donald Trump as he weighs escalating the war, now in its sixth week.
The airman rescued by special operations forces, who Trump said was a colonel, was the weapons-systems officer on the downed F-15, a US official told Reuters.
“Over the past several hours, the United States Military pulled off one of the most daring Search and Rescue Operations in US History,” Trump said in a statement, adding that the airman was injured but “he will be just fine.”
The officer was the second of two crew members on the warplane that Iran said on Friday had been brought down by its air defenses. Iran’s Revolutionary Guards said several aircraft were destroyed during the US rescue mission, Tasnim news agency reported.
Reuters reported on Friday that the first crew member had been retrieved, triggering a high-profile search by both Iran and the United States for the remaining airman.
Iranian officials had urged citizens to help find him, hoping to gain leverage against Washington in the war Trump and Israel launched on February 28.
Trump has threatened to escalate the conflict in the coming days with attacks on Iran’s energy infrastructure.
Had Iran captured the airman, the ensuing hostage crisis could have shifted American public perception of a conflict that opinion polls show was already unpopular.
Trump said the airman was rescued “in the treacherous mountains of Iran” in what he said was the first time in military memory that two US pilots had been rescued, separately, deep in enemy territory.
The official told Reuters that as the weapons-systems officer was moved from near a mountain to a transport aircraft parked within Iran, US forces had to destroy at least one of the aircraft because it had malfunctioned.
U.S. AIRCRAFT HIT
The rescue effort, involving dozens of military aircraft, encountered fierce resistance from Iran.
Reuters reported on Friday that two Black Hawk helicopters involved in the search were hit by Iranian fire but escaped from Iranian airspace.
Separately, a pilot ejected from an A-10 Warthog fighter aircraft after it was hit over Kuwait and crashed, the officials said, though the extent of crew injuries was unclear.
Still, Trump was triumphant.
“The fact that we were able to pull off both of these operations, without a SINGLE American killed, or even wounded, just proves once again, that we have achieved overwhelming Air Dominance and Superiority over the Iranian skies,” he said in his statement.
US air crews are trained in what to do if they go down behind enemy lines, measures known as Survival, Evasion, Resistance and Escape, but few are fluent in Persian and face a challenge in staying undetected while seeking rescue.
The conflict has killed 13 US military service members, with more than 300 wounded, US Central Command says. No US troops have been taken prisoner by Iran.
While Trump has repeatedly sought to portray the Iranian military as being in tatters, they have repeatedly been able to hit US aircraft.
Reuters reported on US intelligence showing that Iran retains large amounts of missile and drone capability. Until just over a week ago, the US could only determine with certainty that it had destroyed about one-third of Iran’s missile arsenal.
The status of about another third was less clear, but bombings probably damaged, destroyed or buried those missiles in underground tunnels and bunkers, Reuters sources said.
The US and Israeli war on Iran has spread across the Middle East, killing thousands and hitting the global economy with soaring energy prices that are fueling fears of inflation.
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On Easter, Pope Leo Urges World Leaders to End Wars, Renounce Conquest
Pope Leo XIV waves from the main balcony of St. Peter’s Basilica after delivering his “Urbi et Orbi” (To the city and the world) message, on Easter Sunday at the Vatican, April 5, 2026. Photo: REUTERS/Remo Casilli
Pope Leo urged global leaders in his Easter message on Sunday to end the conflicts raging across the world and abandon any schemes for power, conquest or domination.
The pope, who has emerged as an outspoken critic of the Iran war, lamented in a special message to the thousands gathered in St. Peter’s Square that people “are growing accustomed to violence, resigning ourselves to it, and becoming indifferent.”
“Let those who have weapons lay them down!” the first US pope exhorted. “Let those who have the power to unleash wars choose peace!”
Leo did not mention any specific conflicts in the message, known as the “Urbi et Orbi” (to the city and the world) blessing. It was unusually brief and direct.
The pope said that the story of Easter, when the Bible says Jesus rose from the dead three days after not resisting his execution by crucifixion, shows that Christ was “entirely nonviolent.”
“On this day of celebration, let us abandon every desire for conflict, domination, and power, and implore the Lord to grant his peace to a world ravaged by wars,” Leo urged.
Leo, who is known for choosing his words carefully, has been forcefully decrying the world’s violent conflicts in recent weeks and ramping up his criticism of the Iran war.
In a sermon for the Easter vigil on Saturday night, he urged people not to feel numbed by the scope of the conflicts raging across the world but to work for peace.
The pope made a rare direct appeal to US President Donald Trump on Tuesday, urging him to find an “off-ramp” to end the Iran war.
In his address from the balcony of St. Peter’s Basilica on Sunday to the Square below, decorated with thousands of brightly colored flowers for the holiday, Leo offered brief Easter greetings in ten languages, including Latin, Arabic and Chinese.
The pope also announced he would return to the Basilica on April 11 to host a prayer vigil for peace.
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Temple Mount Set for Limited Reopening to Jews and Muslims
Israeli National Security Minister and head of Jewish Power party Itamar Ben-Gvir gives a statement to members of the press, ahead of a possible ceasefire between Israel and Hamas, in Jerusalem, Jan. 16, 2025. Photo: REUTERS/Oren Ben Hakoon
i24 News – Israeli authorities are preparing to partially reopen the Temple Mount in Jerusalem to both Jewish and Muslim worshipers for the first time since the start of the war with Iran, under a tightly controlled and highly restricted security arrangement, i24NEWS has learned.
According to details obtained by i24NEWS, the Israeli police, backed by National Security Minister Itamar Ben-Gvir, are also expected to permit limited access for Jewish worshipers to the Western Wall as part of the same phased plan.
Under the framework, access to the Temple Mount and surrounding holy sites would be restricted to small groups of up to 150 people at a time. In the event of a missile alert, all visitors would be immediately evacuated in accordance with emergency protocols.
The decision follows a recent Supreme Court ruling allowing demonstrations in a limited format. Police argue that a consistent standard must apply across both civic gatherings and religious sites, with Ben-Gvir insisting that “there cannot be one rule for demonstrations and another for the Temple Mount.”
However, the reopening contradicts recommendations from the Home Front Command, which has advised keeping sensitive sites closed due to the ongoing risk of missile attacks.
Israeli Justice Minister Yariv Levin has proposed transferring authority over such security-related decisions exclusively to defense officials, an initiative that could reshape the balance between the judiciary and security establishment regarding restrictions on public access.