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Raphael Mechoulam, Israel’s ‘father of cannabis research,’ dies at 92
(JTA) — In the early 1960s, a Bulgarian-born scientist named Raphael Mechoulam was caught carrying five kilograms of, as he called it, “superb, smuggled Lebanese hashish” on a bus from Tel Aviv to Rehovot. But he wasn’t planning on smoking the stuff.
Mechoulam was a fledgling researcher keen on exploring the science behind cannabis, a stigmatized plant whose specific medical properties were not yet known. Over the decades he became a pioneer in cannabis research, whose findings about the psychoactive substance helped ease its entry out of the counterculture and into the mainstream.
Mechoulam died in Israel at age 92; his death was announced Friday by American Friends of the Hebrew University, where Mechoulam helped form The Hebrew University Multidisciplinary Center for Cannabinoid Research in 2017.
“Most of the human and scientific knowledge about cannabis was accumulated thanks to Prof. Mechoulam,” Hebrew University President Asher Cohen said in a statement. “He paved the way for groundbreaking studies and initiated scientific cooperation between researchers around the world. Mechoulam was a sharp-minded and charismatic pioneer.”
As a professor in the Hebrew University School of Pharmacy, Mechoulam and his research team isolated THC, the psychoactive component of cannabis, as well as cannabidiol, or CBD, an active ingredient in cannabis with a range of medicinal benefits.
He also pioneered the study of the body’s own cannabinoid system, which produces chemicals similar to THC to help regulate appetite, manage pain and operate the immune system.
As Mechoulam discovered more about cannabis and its efficacy in easing symptoms of cancer, epilepsy and other diseases, he lamented that strict drug laws in the United States and elsewhere suppressed research and kept the derivatives of cannabis off the market.
“Medicinal cannabis has to follow medical lines of thought and development and modern medical routes” in order to be part of proper drugs, he told the New York Times in 2017. “Israel has more [clinical trials] than the United States at the moment, which is ridiculous.”
Mechoulam was a founding member of the International Association for Cannabinoid Medicines and the International Cannabinoid Research Society. In 1994, he was elected to be a member of the Israel Academy of Sciences and Humanities.
Mechoulam was born in Bulgaria in 1930 and immigrated in 1949 with his family to Israel, where he later studied chemistry. He received his PhD at the Weizmann Institute in Rehovot, writing a thesis on the chemistry of steroids. After postdoctoral studies at the Rockefeller Institute in New York, he joined the scientific staff of the Weizmann Institute.
Mechoulam became a full professor at Hebrew University in 1972 and was named the Lionel Jacobson Professor of Medicinal Chemistry in 1975, serving as the university’s rector from 1979-1982.
In 2022, the YIVO Institute for Jewish Research in New York City mounted its exhibition on Jewish contributions to the history of cannabis and highlighted the work of Mechoulam. “He’s worked on cannabis his entire life, and in the 1990s he and his colleagues discovered the endocannabinoid system, which regulates homeostasis — a significant discovery on how the human body deals with cannabinoids,” Eddy Portnoy, who curated the exhibit, told the Jewish Telegraphic Agency at the time. “I read an interview with him where he says that because he was in a small country, he would have to find a niche that other people weren’t working in.”
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Netanyahu: ‘Our Forces Are Striking the Heart of Tehran With Increasing Strength’
Israeli Prime Minister Benjamin Netanyahu participates in the state memorial ceremony for the fallen of the Iron Swords War on Mount Herzl, in Jerusalem, Oct. 16, 2025. Photo: Alex Kolomoisky/Pool via REUTERS
i24 News – Israeli Prime Minister Benjamin Netanyahu stated that Israeli forces had “eliminated the dictator Ali Khamenei” along with dozens of senior officials of Iran’s regime during a statement delivered from the roof of the Kirya, Israel’s defense headquarters.
“Yesterday, we eliminated the dictator Khamenei. Along with him, dozens of senior officials from the oppressive regime were eliminated,” Netanyahu said after a meeting with the Minister of Defense, the Chief of Staff, and the Director of Mossad. He added that he had issued instructions to continue the offensive.
According to Netanyahu, Israeli forces are “now striking at the heart of Tehran with increasing intensity,” a campaign he said will “increase further in the days to come.”
The Prime Minister also acknowledged the toll of the conflict on Israel, calling recent days “painful” and offering condolences to the families of victims in Tel Aviv and Beit Shemesh, while wishing a speedy recovery to those injured.
Netanyahu emphasized that the operation mobilizes “the full power of the Israel Defense Forces, like never before,” in order to “guarantee our existence and our future.” He also highlighted US support, noting “the assistance of my friend, the President of the United States, Donald Trump, and of the American military.”
“This combination of forces allows us to do what I have hoped to accomplish for 40 years: strike the terrorist regime right in the face,” Netanyahu concluded. “I promised it — and we will keep our word.”
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Trump Says Iran Military Operations Are ‘Ahead of Schedule,’ CNBC Reports
U.S. President Donald Trump speaks with White House Chief of Staff Susie Wiles and Secretary of State Marco Rubio during military operations in Iran, at Trump’s Mar-a-Lago resort in Palm Beach, Florida, U.S. February 28, 2026. The White House/Social Media/Handout via REUTERS
US President Donald Trump told CNBC on Sunday that US military operations against Iran are “ahead of schedule.”
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Iranian Missile Strike on Beit Shemesh in Israel Kills 9
Emergency personnel work at the site of an Iranian strike, after Iran launched missile barrages following attacks by the US and Israel on Saturday, in Beit Shemesh, Israel, March 1, 2026. Photo: REUTERS/Ammar Awad
An Iranian missile strike hit the Israeli city of Beit Shemesh on Sunday, killing nine people and wounding dozens, in what authorities described as a direct impact on a public bomb shelter.
A ballistic missile leveled the bomb shelter, leaving a large crater in its wake. Most, if not all, of those killed had been taking cover inside the shelter when it hit, Jerusalem Police Deputy Commissioner Avshalom Peled said at the impact scene.
Those in critical condition were airlifted to Shaare Zedek Medical Center, a spokesperson for the Israel Defense Forces (IDF) said.
At least 20 people were still missing late on Sunday afternoon local time.
As you read this, an Iranian missile has just struck a residential neighborhood in Beit Shemesh, Israel, only 30 kilometers/about 18 miles from Jerusalem.
Nine people are dead.
More than 20 are wounded, including children. A
public shelter collapsed from the direct hit. An… pic.twitter.com/mEVDlPEqgf
— Ella Kenan (@EllaTravelsLove) March 1, 2026
Several buildings surrounding the shelter in Beit Shemesh, which is west of Jerusalem, were also damaged in the attack, with two collapsing entirely. A synagogue was also destroyed.
Emergency crews from Magen David Adom, ZAKA, and United Hatzalah joined fire and rescue units at the site, combing damaged buildings and debris for possible survivors. Many people were trapped under rubble or inside apartments, first responders said.
The Iranian Regime directly fired missiles toward the civilian neighborhood of Beit Shemesh, killing innocent civilians.
The Iranian regime purposely targets civilian targets while we precisely target terror targets. This is who we’re operating against—a regime who uses… pic.twitter.com/9W8Fp4T2tH
— Israel Defense Forces (@IDF) March 1, 2026
Chaim Wingarten, deputy director of operations at rescue organization ZAKA, described the scenes as “very difficult.”
“When I arrived, it was a huge chaos, with wounded people everywhere,” he said.
The strike was part of a larger volley that triggered air-raid sirens across the country. A man in his fifties was wounded by shrapnel elsewhere in central Israel.
IDF foreign media spokesman Lt. Col. Nadav Shoshani charged Iran with deliberately firing at civilians. “We know this is their strategy,” he said, adding that Israel would do “everything in our power to remove these capabilities from this bloodthirsty terrorist regime.”
The Beit Shemesh hit marked the highest single-incident death toll inside Israel since the confrontation with Iran began a day earlier. The previous peak came during the 12-day war in June 2025, when a missile slammed into an apartment block in Bat Yam and killed nine people.
The Beit Shemesh strike came a day after US and Israeli forces struck a compound in Tehran killing senior Iranian officials, including Supreme Leader Ayatollah Ali Khamenei, whose death was later announced on Iranian state television.
In an interview with Fox News on Sunday, Trump said 48 Iranian leaders were killed in the strikes. “Nobody can believe the success we’re having; 48 leaders are gone in one shot. And it’s moving along rapidly,” he said.
Separately, the American president told CNBC that the US operation was “ahead of schedule.”
Thousands of Iranians braved the strikes and took to the streets to celebrate Khamenei’s death on Saturday evening. Many people stood on balconies and at windows chanting “freedom, freedom,” The New York Times reported. People in the Iranian city of Shiraz were “abandoning their cars for an impromptu dance party, whistling, cheering, clapping, and screaming with joy. In many videos, celebrants joined together in a cheer that is typically reserved for weddings, symbolizing pure joy,” the report said.
GeoConfirmed Iran.
People chanting – Celebrations through the Foolad Shahr area in Isfahan with joy and jubilation over the killing of Khamenei.
Rough location – 32.48169, 51.39167
F9JR+MMF Fuladshahr, Isfahan Province, IranGeoLocated by @Mitch_Ulrich
Geolocation:… https://t.co/iv9TlSPPfS
— GeoConfirmed (@GeoConfirmed) February 28, 2026
Can you hear the joy in his voice?
“I am dreaming, hello world!” pic.twitter.com/ICq77zBerv— William Mehrvarz (@WilliamMehrvarz) March 1, 2026
Iran retaliated by firing repeated waves of missiles and drones, with launches aimed not only at Israel but also at US bases in the Middle East, including Qatar, Kuwait, the United Arab Emirates, and Bahrain. Iran on Sunday morning also launched two missiles at Cyprus, where thousands of British military personnel are stationed, which fell short.
Later in the afternoon, the US acknowledged its first losses with US Central Command, saying three American service members were killed and five were seriously wounded during the operations in Iran.