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Raphael Mechoulam, Israel’s ‘father of cannabis research,’ dies at 92
(JTA) — In the early 1960s, a Bulgarian-born scientist named Raphael Mechoulam was caught carrying five kilograms of, as he called it, “superb, smuggled Lebanese hashish” on a bus from Tel Aviv to Rehovot. But he wasn’t planning on smoking the stuff.
Mechoulam was a fledgling researcher keen on exploring the science behind cannabis, a stigmatized plant whose specific medical properties were not yet known. Over the decades he became a pioneer in cannabis research, whose findings about the psychoactive substance helped ease its entry out of the counterculture and into the mainstream.
Mechoulam died in Israel at age 92; his death was announced Friday by American Friends of the Hebrew University, where Mechoulam helped form The Hebrew University Multidisciplinary Center for Cannabinoid Research in 2017.
“Most of the human and scientific knowledge about cannabis was accumulated thanks to Prof. Mechoulam,” Hebrew University President Asher Cohen said in a statement. “He paved the way for groundbreaking studies and initiated scientific cooperation between researchers around the world. Mechoulam was a sharp-minded and charismatic pioneer.”
As a professor in the Hebrew University School of Pharmacy, Mechoulam and his research team isolated THC, the psychoactive component of cannabis, as well as cannabidiol, or CBD, an active ingredient in cannabis with a range of medicinal benefits.
He also pioneered the study of the body’s own cannabinoid system, which produces chemicals similar to THC to help regulate appetite, manage pain and operate the immune system.
As Mechoulam discovered more about cannabis and its efficacy in easing symptoms of cancer, epilepsy and other diseases, he lamented that strict drug laws in the United States and elsewhere suppressed research and kept the derivatives of cannabis off the market.
“Medicinal cannabis has to follow medical lines of thought and development and modern medical routes” in order to be part of proper drugs, he told the New York Times in 2017. “Israel has more [clinical trials] than the United States at the moment, which is ridiculous.”
Mechoulam was a founding member of the International Association for Cannabinoid Medicines and the International Cannabinoid Research Society. In 1994, he was elected to be a member of the Israel Academy of Sciences and Humanities.
Mechoulam was born in Bulgaria in 1930 and immigrated in 1949 with his family to Israel, where he later studied chemistry. He received his PhD at the Weizmann Institute in Rehovot, writing a thesis on the chemistry of steroids. After postdoctoral studies at the Rockefeller Institute in New York, he joined the scientific staff of the Weizmann Institute.
Mechoulam became a full professor at Hebrew University in 1972 and was named the Lionel Jacobson Professor of Medicinal Chemistry in 1975, serving as the university’s rector from 1979-1982.
In 2022, the YIVO Institute for Jewish Research in New York City mounted its exhibition on Jewish contributions to the history of cannabis and highlighted the work of Mechoulam. “He’s worked on cannabis his entire life, and in the 1990s he and his colleagues discovered the endocannabinoid system, which regulates homeostasis — a significant discovery on how the human body deals with cannabinoids,” Eddy Portnoy, who curated the exhibit, told the Jewish Telegraphic Agency at the time. “I read an interview with him where he says that because he was in a small country, he would have to find a niche that other people weren’t working in.”
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Report: Regime Change Not Ruled Out as US Mulls Escalation Against Venezuela
Venezuelan President Nicolas Maduro speaks during a march amid the disputed presidential election, in Caracas, Venezuela, Aug. 3, 2024. Photo: REUTERS/Maxwell Briceno
i24 News – The United States is poised to launch a new phase of Venezuela-related operations in the coming days, as the US administration of President Donald Trump ratchets up pressure on President Nicolas Maduro’s government, Reuters reported Saturday citing four officials familiar with the matter. An escalation that would go so far as overthrowing Maduro’s dictatorial regime could not be ruled out, it is understood.
The report could not provide the exact timing or scope of the new operations, nor confirm that Trump had made a final decision to act. Reports of looming action have proliferated in recent weeks as the US military has deployed forces to the Caribbean amid worsening relations with Venezuela.
Two of the US officials said covert operations would likely be the first part of the new action against Maduro. Another “senior administration official” said he did not rule anything out regarding Venezuela.
“President Trump is prepared to use every element of American power to stop drugs from flooding into our country and to bring those responsible to justice,” the official was quoted as saying.
Also on Saturday, three international airlines canceled their flights departing from Venezuela, the day after the US Federal Aviation Administration warned major airlines of a “potentially hazardous situation” when flying over the country.
Brazil’s Gol, Colombia’s Avianca and TAP Air Portugal canceled their flights departing from Caracas on Saturday, according to Flightradar24 and the official website of Simon Bolivar Maiquetia International Airport.
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Indonesia’s Biggest Islamic Group Asks Chief to Resign Over Invitation to Pro-Israeli Speaker
Then Israeli Prime Minister Benjamin Netanyahu meets with Yahya Cholil Staquf, secretary general of the 60-million member Nahdlatul Ulama, Indonesia’s largest Muslim organization, at his office in Jerusalem. Photo: Haim Zach/GPO.
Indonesia’s biggest Islamic organization, Nahdlatul Ulama, has asked its chief to resign for inviting a US scholar known for his support of Israel during the Gaza war to an internal event in August, according to meeting minutes reviewed by Reuters.
The leadership of NU, which is also the world’s biggest Islamic organization with around 100 million members and affiliates, has given Chairman Yahya Cholil Staquf three days to offer his resignation or be removed from his post, according to the minutes from a meeting on Thursday.
NU cited Staquf’s invitation to a person “affiliated with an International Zionism network” for an internal event and alleged financial mismanagement as reasons for his ouster.
Staquf, who has been NU’s chairman since 2021, did not immediately respond to a request for comment.
NU official Najib Azca told Reuters the decision was linked to Staquf’s invitation to former US official and scholar Peter Berkowitz for an August training event.
Staquf has apologized for the invitation and called it an oversight as he had not carefully checked Berkowitz’s background, adding that he condemned Israel‘s “brutal genocidal acts in Gaza.”
Berkowitz often writes in support of Israel‘s campaign in Gaza, according to his website, including a piece in September aiming to refute allegations of genocide against Israel.
Berkowitz spoke at NU seminars about the history of Western political thought in August, his website showed.
Berkowitz did not immediately respond to an email requesting comment that reached him outside of office hours.
Indonesia, the world’s Muslim-majority nation, has routinely condemned Israel‘s actions in the Palestinian enclave of Gaza since the war broke out in 2023. It has long advocated for a two-state solution and has no diplomatic relations with Israel.
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Protesters at Tel Aviv Rally Call for State Inquiry into Oct. 7 Failings
Israeli Prime Minister Benjamin Netanyahu participates in the state memorial ceremony for the fallen of the Iron Swords War on Mount Herzl. In Jerusalem on 16 October 2025. Photo: Alex Kolomoisky/POOL/Pool via REUTERS
i24 News – Israeli protesters gathered on Saturday in Tel Aviv, to demand the government of Prime Minister Benjamin Netanyahu appoint a committee to initiate a state inquiry on the security failings of October 7.
Saturday night rallies in Tel Aviv have been a fixture of the two-year-long war in Gaza that was triggered by the Hamas-led cross-border attack on October 7, 2023, that saw the worst massacre of Jews since the Holocaust.
Protesters charged that Netanyahu refuses to be held accountable for his share of responsibility in Israel’s blackest day. They likewise took exception to Netanyahu’s wish to select the members of the committee, arguing this represented subversion of the democratic process.
Protesters also demanded the return of remains of the three deceased hostages still remaining in Gaza: Ran Gvili, Dror or and Sudthisak Rinthalak.