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Raphael Mechoulam, Israel’s ‘father of cannabis research,’ dies at 92
(JTA) — In the early 1960s, a Bulgarian-born scientist named Raphael Mechoulam was caught carrying five kilograms of, as he called it, “superb, smuggled Lebanese hashish” on a bus from Tel Aviv to Rehovot. But he wasn’t planning on smoking the stuff.
Mechoulam was a fledgling researcher keen on exploring the science behind cannabis, a stigmatized plant whose specific medical properties were not yet known. Over the decades he became a pioneer in cannabis research, whose findings about the psychoactive substance helped ease its entry out of the counterculture and into the mainstream.
Mechoulam died in Israel at age 92; his death was announced Friday by American Friends of the Hebrew University, where Mechoulam helped form The Hebrew University Multidisciplinary Center for Cannabinoid Research in 2017.
“Most of the human and scientific knowledge about cannabis was accumulated thanks to Prof. Mechoulam,” Hebrew University President Asher Cohen said in a statement. “He paved the way for groundbreaking studies and initiated scientific cooperation between researchers around the world. Mechoulam was a sharp-minded and charismatic pioneer.”
As a professor in the Hebrew University School of Pharmacy, Mechoulam and his research team isolated THC, the psychoactive component of cannabis, as well as cannabidiol, or CBD, an active ingredient in cannabis with a range of medicinal benefits.
He also pioneered the study of the body’s own cannabinoid system, which produces chemicals similar to THC to help regulate appetite, manage pain and operate the immune system.
As Mechoulam discovered more about cannabis and its efficacy in easing symptoms of cancer, epilepsy and other diseases, he lamented that strict drug laws in the United States and elsewhere suppressed research and kept the derivatives of cannabis off the market.
“Medicinal cannabis has to follow medical lines of thought and development and modern medical routes” in order to be part of proper drugs, he told the New York Times in 2017. “Israel has more [clinical trials] than the United States at the moment, which is ridiculous.”
Mechoulam was a founding member of the International Association for Cannabinoid Medicines and the International Cannabinoid Research Society. In 1994, he was elected to be a member of the Israel Academy of Sciences and Humanities.
Mechoulam was born in Bulgaria in 1930 and immigrated in 1949 with his family to Israel, where he later studied chemistry. He received his PhD at the Weizmann Institute in Rehovot, writing a thesis on the chemistry of steroids. After postdoctoral studies at the Rockefeller Institute in New York, he joined the scientific staff of the Weizmann Institute.
Mechoulam became a full professor at Hebrew University in 1972 and was named the Lionel Jacobson Professor of Medicinal Chemistry in 1975, serving as the university’s rector from 1979-1982.
In 2022, the YIVO Institute for Jewish Research in New York City mounted its exhibition on Jewish contributions to the history of cannabis and highlighted the work of Mechoulam. “He’s worked on cannabis his entire life, and in the 1990s he and his colleagues discovered the endocannabinoid system, which regulates homeostasis — a significant discovery on how the human body deals with cannabinoids,” Eddy Portnoy, who curated the exhibit, told the Jewish Telegraphic Agency at the time. “I read an interview with him where he says that because he was in a small country, he would have to find a niche that other people weren’t working in.”
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Report: Iran’s New Military Plan Is Regime Survival Through Regional Escalation
Members of the Islamic Revolutionary Guard Corps (IRGC) attend an IRGC ground forces military drill in the Aras area, East Azerbaijan province, Iran, Oct. 17, 2022. Photo: IRGC/WANA (West Asia News Agency)/Handout via REUTERS
i24 News – After last year’s devastating conflict with the United States and Israel, Iranian leaders have reportedly adopted a major strategic shift aimed at expanding the war across the Middle East to secure the regime’s survival, according to the Wall Street Journal.
Previously, Iran responded to foreign strikes with limited, targeted reprisals. The new doctrine abandons that approach, aiming instead to escalate the conflict regionally, particularly against Gulf Arab states and critical economic infrastructure. The goal is to disrupt the global economy and pressure Washington into shortening the war.
This decision followed the twelve-day war with Israel in June 2025, during which Israeli and US strikes eliminated senior Iranian military leaders, destroyed key air defense systems, and severely damaged nuclear facilities. In response, Supreme Leader Ali Khamenei—before his elimination early in the current conflict—activated a strategy designed to maintain continuity even if top commanders were neutralized.
Central to this approach is the so-called “mosaic defense” doctrine: a decentralized military structure in which the Islamic Revolutionary Guard Corps (IRGC) operates through multiple regional command centers. Each center can conduct operations independently, allowing local commanders to continue fighting even if national leadership is incapacitated. This makes the military apparatus more resilient to targeted strikes.
Analysts cited by the Wall Street Journal suggest that Tehran’s calculation is to make the conflict costly enough for all parties to force the US and its allies into a diplomatic resolution.
However, the plan carries enormous risks. By escalating attacks on regional states and international economic interests, Iran could provoke a broader coalition against itself. Despite prior military losses, Iranian forces retain the capability to launch drone and missile strikes, maintaining their influence over the ongoing conflict.
For Iranian leaders, the immediate priority remains unchanged: the survival of the regime, even if it requires a major regional escalation.
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Katz Warns Lebanon to Disarm Hezbollah or ‘Pay a Heavy Price’
Israel’s Defense Minister Israel Katz and his Greek counterpart Nikos Dendias make statements to the press, at the Ministry of Defense in Athens Greece, Jan. 20, 2026. Photo: REUTERS/Louisa Gouliamaki
i24 News – Israeli Defense Minister Israel Katz on Saturday warned Lebanon’s leadership that it must act to disarm Hezbollah and enforce existing agreements, cautioning that failure to do so could lead to severe consequences for the Lebanese state.
Speaking after a high-level security assessment with senior military officials, Katz directed a message to Lebanese President Joseph Aoun, saying Beirut had committed to enforcing an agreement requiring Hezbollah’s disarmament but had failed to follow through.
“You pledged to uphold the agreement and disarm Hezbollah — and this is not happening,” Katz said. “Act and enforce it before we do even more.”
The meeting took place in Israel’s military command center and included Chief of Staff Lt. Gen. Eyal Zamir and other senior defense officials, as Israel continues operations on multiple fronts.
Katz emphasized that Israel would not tolerate attacks on its communities or soldiers from Lebanese territory.
“We will not allow harm to our communities or to our soldiers,” he said. “If the choice is between protecting our citizens and soldiers or protecting the State of Lebanon, we will choose our citizens and soldiers — and the Lebanese government and Lebanon will pay a very heavy price.”
The defense minister also referenced Hezbollah’s leadership, warning that the group’s current chief could lead Lebanon into further destruction.
“If Hassan Nasrallah destroyed Lebanon, then Naim Qassem will destroy it as well,” Katz said.
Katz stressed that Israel has no territorial ambitions in Lebanon but said it would not accept a return to the years in which Hezbollah launched repeated attacks on Israel from Lebanese territory.
“We have no territorial claims against Lebanon,” he said. “But we will not allow Lebanese territory to again become a platform for attacks against the State of Israel.”
He concluded with a warning to Lebanese authorities to take action against Hezbollah before Israel escalates its response.
“Do and act before we do even more,” Katz said.
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Trump Explores Possibility of Limited US Ground Deployment in Iran
United States President Donald J Trump in White House in Washington, DC, USA, on Thursday, December 18, 2025. Photo: Aaron Schwartz via Reuters Connect.
i24 News – US President Donald Trump has discussed the possibility of sending American ground forces into Iran as part of broader planning for how the country could be managed after the current conflict, reports NBC News.
The topic reportedly arose in discussions with senior aides and Republican figures outside the White House, where Trump outlined his thinking about what a post-war Iran might look like if the current confrontation significantly weakens the ruling regime. According to people briefed on those talks, the president has spoken about the need to secure Iran’s uranium reserves and prevent nuclear materials from falling into the wrong hands during any potential political transition.
Sources say Trump’s comments did not focus on the idea of a large-scale US military invasion. Instead, the discussions centered on a far more limited scenario involving a small contingent of American troops tasked with specific strategic missions. Such forces could potentially be deployed to secure sensitive nuclear facilities, protect critical infrastructure, or support stabilization efforts during a transitional period.
Those familiar with the conversations said the idea has been presented as one possible option among several scenarios being considered as the conflict evolves. Trump has reportedly also described a longer-term vision in which a new Iranian leadership could cooperate with Washington economically, particularly in the energy sector. In private conversations, he has suggested that the United States could eventually work with a post-regime Iran on oil production arrangements, drawing comparisons to the current cooperation between Washington and Venezuela.