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Raphael Mechoulam, Israel’s ‘father of cannabis research,’ dies at 92
(JTA) — In the early 1960s, a Bulgarian-born scientist named Raphael Mechoulam was caught carrying five kilograms of, as he called it, “superb, smuggled Lebanese hashish” on a bus from Tel Aviv to Rehovot. But he wasn’t planning on smoking the stuff.
Mechoulam was a fledgling researcher keen on exploring the science behind cannabis, a stigmatized plant whose specific medical properties were not yet known. Over the decades he became a pioneer in cannabis research, whose findings about the psychoactive substance helped ease its entry out of the counterculture and into the mainstream.
Mechoulam died in Israel at age 92; his death was announced Friday by American Friends of the Hebrew University, where Mechoulam helped form The Hebrew University Multidisciplinary Center for Cannabinoid Research in 2017.
“Most of the human and scientific knowledge about cannabis was accumulated thanks to Prof. Mechoulam,” Hebrew University President Asher Cohen said in a statement. “He paved the way for groundbreaking studies and initiated scientific cooperation between researchers around the world. Mechoulam was a sharp-minded and charismatic pioneer.”
As a professor in the Hebrew University School of Pharmacy, Mechoulam and his research team isolated THC, the psychoactive component of cannabis, as well as cannabidiol, or CBD, an active ingredient in cannabis with a range of medicinal benefits.
He also pioneered the study of the body’s own cannabinoid system, which produces chemicals similar to THC to help regulate appetite, manage pain and operate the immune system.
As Mechoulam discovered more about cannabis and its efficacy in easing symptoms of cancer, epilepsy and other diseases, he lamented that strict drug laws in the United States and elsewhere suppressed research and kept the derivatives of cannabis off the market.
“Medicinal cannabis has to follow medical lines of thought and development and modern medical routes” in order to be part of proper drugs, he told the New York Times in 2017. “Israel has more [clinical trials] than the United States at the moment, which is ridiculous.”
Mechoulam was a founding member of the International Association for Cannabinoid Medicines and the International Cannabinoid Research Society. In 1994, he was elected to be a member of the Israel Academy of Sciences and Humanities.
Mechoulam was born in Bulgaria in 1930 and immigrated in 1949 with his family to Israel, where he later studied chemistry. He received his PhD at the Weizmann Institute in Rehovot, writing a thesis on the chemistry of steroids. After postdoctoral studies at the Rockefeller Institute in New York, he joined the scientific staff of the Weizmann Institute.
Mechoulam became a full professor at Hebrew University in 1972 and was named the Lionel Jacobson Professor of Medicinal Chemistry in 1975, serving as the university’s rector from 1979-1982.
In 2022, the YIVO Institute for Jewish Research in New York City mounted its exhibition on Jewish contributions to the history of cannabis and highlighted the work of Mechoulam. “He’s worked on cannabis his entire life, and in the 1990s he and his colleagues discovered the endocannabinoid system, which regulates homeostasis — a significant discovery on how the human body deals with cannabinoids,” Eddy Portnoy, who curated the exhibit, told the Jewish Telegraphic Agency at the time. “I read an interview with him where he says that because he was in a small country, he would have to find a niche that other people weren’t working in.”
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US-Israeli Attack Triggers Fear and Panic in Iran
Buildings stand, after Israel and the US launched strikes on Iran, in Tehran, Iran, February 28, 2026. Photo: Majid Asgaripour/WANA (West Asia News Agency) via REUTERS
Iranians fled cities in search of safety, and long queues formed at fuel stations as an attack on Iran by the United States and Israel spread fear and panic throughout the country.
When the strikes began on Saturday morning, explosions rocked Tehran and columns of smoke rose into the sky, shaking the city at the start of the Iranian working week.
Residents reached by phone described scenes of chaos and alarm as they rushed to collect their children from school or made preparations to leave home for now.
“We are going to our hometown in Yazd, Tehran is not safe anymore. They said roads are safe, but I am worried,” said Gholamreza, a Tehran shopkeeper and father of two. “I am leaving everything behind in Tehran.”
It marks the latest upheaval for Iranians weeks after thousands of people were killed in a government crackdown on nationwide unrest, and comes just eight months after last year’s 12-day war with Israel, during which the United States bombed Iranian nuclear sites.
Iran’s top security body said it expected attacks to continue on Tehran and some other cities, and urged people to “travel to other cities where possible so that you may remain safe from the harm of these two regimes’ acts of aggression.” Schools and universities would be closed until further notice.
“We are scared, we are terrified. My children are shaking, we have nowhere to go, we will die here,” said Minou, a 32-year-old mother of two from the northern city of Tabriz, one of many areas where explosions were reported.
“What is going to happen to my children?” she said, crying as she spoke by phone.
US President Donald Trump said the operation would end a security threat to the United States and offer Iranians a chance to topple their rulers. The Pentagon said that US strikes against Iran were named “OPERATION EPIC FURY.”
An Iranian from the central city of Yazd said he hoped the attack would topple the clerical establishment that has run the country since the 1979 Islamic Revolution. “Let them bomb,” the resident of Yazd said.
Samira Mohebbi, speaking from the northern city of Rasht, disagreed.
“I am against this regime, to hell with them. But I don’t want my country to be attacked by foreign forces, I don’t want my Iran to turn into Iraq,” she said, referring to the neighboring country that suffered years of chaos and bloodshed following the U.S.-led invasion that toppled Saddam Hussein.
‘THEY FOOLED US AGAIN’
Security forces blocked roads in the area of Tehran that is home to the offices of Supreme Leader Ayatollah Ali Khamenei, President Masoud Pezeshkian and parliament, witnesses said.
The latest round of negotiations between the United States and Iran in Geneva on Thursday failed to secure a breakthrough over Tehran’s nuclear programme, though Omani mediators reported progress.
“They said the nuclear talks are going well. They fooled us again,” said a resident of Tehran.
Zohreh, 28, said she would leave the port city of Bushehr with her three-year-old daughter and go to her parents’ home in a village in northern Iran.
“Why are we paying this price? I want my daughter to grow up safe and in peace,” she said.
Western governments have long suspected Iran aims to build a nuclear bomb. Tehran has always denied this.
Witnesses said people were rushing to buy hard currency.
In Isfahan, another area where attacks were reported, some said they were unable to withdraw cash from ATMs.
Reza Saadati, 45, said he was taking his family to the city of Urumieh near the Turkish border. “If the border is open, we will cross and then fly to Istanbul,” he said.
Mohammad Esmaili, 63, speaking from the town of Ilam, some 500 km (300 miles) from Tehran, said he would leave the town with his family. “God knows what will happen to us. Pray for us,” he said.
“People are shocked, scared. What is going to happen to us? Save us please,” said a woman from Tehran.
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Prior to Iran attacks, CIA assessed Khamenei Would Be Replaced by IRCG Elements if Killed
Members of the Islamic Revolutionary Guard Corps (IRGC) attend an IRGC ground forces military drill in the Aras area, East Azerbaijan province, Iran, Oct. 17, 2022. Photo: IRGC/WANA (West Asia News Agency)/Handout via REUTERS
In the run-up to the US and Israeli attacks on Saturday, the US Central Intelligence Agency assessed that even if Iran’s Supreme Leader Ayatollah Ali Khamenei was killed in the operation, he would likely be replaced by hardline figures from the Islamic Revolutionary Guard Corps (IRGC), two sources briefed on the intelligence said.
The assessments, which were produced over the past two weeks, looked broadly at what could occur in Iran following a US intervention and the extent to which a military operation could trigger regime change in the Islamic Republic — now a pronounced objective for Washington.
The IRGC is an elite military force whose purpose is to protect Shi’ite Muslim clerical rule in Iran.
The intelligence agency reports did not conclude any scenario with certainty, said the sources, who spoke on condition of anonymity to discuss intelligence matters.
The Central Intelligence Agency declined to comment.
President Donald Trump has for weeks signaled the US was interested in seeing regime change in Iran, but has not given in any detail Washington’s thinking on who could lead the country.
In an early morning video address on Saturday, Trump described Tehran as a “terrorist regime” and encouraged the Iranian people to take over the government, saying the US military strikes would set the stage for an uprising.
The US and Israeli assault comes after weeks of deliberation inside the US government about whether to strike Iran following the deadly protests that broke out there in December.
US officials in recent weeks have tried to strike a nuclear deal with Tehran in an attempt to stave off intervention.
In a briefing last week, Secretary of State Marco Rubio told top congressional lawmakers known as the Gang of Eight that a US operation would likely move forward, but that Trump could change his mind, particularly if nuclear negotiations were successful. Those talks in Geneva did not result in an agreement.
Rubio notified the Gang of Eight on Friday night that the operation to attack Iran was likely to commence in the following hours but said Trump could still change his mind, two sources familiar with the matter said.
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US and Israel Launched Military Operation Against Islamic Republic: This Is What We Know So Far
Iranian mourners wave the country’s flags while participating in a memorial ceremony for IRGC commanders, nuclear scientists, and civilians killed in the Iran-Israel war at the Imam Khomeini Grand Mosque in downtown Tehran, Iran, on July 2, 2025. Photo: Morteza Nikoubazl via Reuters Connect.
i24 News – It’s been just over ten hours since the US and Israel launched operations “Epic Fury” and “Roaring Lion” against the Islamic Republic. And while this is still a developing story, here is what we know.
Just after 8 am local time the US and Israel launched a series of strikes on Iranian military targets across Iran. The main targets were Iran’s leaders and IRGC senior commanders in Iran and some targets in Iraq.
The IDF says it struck hundreds of targets, including ready-to-fire ballistic missile launchers. While there is no official confirmation of any specific eliminations, Iran’s foreign minister confirmed that some senior commanders were eliminated.
As Israeli and US strikes continued, Iran launched numerous ballistic missile barrages across Israel, and against six Arab countries, namely Saudi Arabia, the UAE, Qatar, Jordan, Kuwait and Bahrain, who all condemned the Iranian strikes on their territory. Iran claims it targeted US military bases in the region.
The escalation also saw a rare sign of unity between Riyadh and Abu Dhabi, who have suffered from tense relations in recent weeks.
Iran has vowed to continue its strikes across the region, with Israeli officials saying they expect the strikes against Iran to continue for at least a few days.
While Iran has already turned this into a regional conflict, it still has potential to expand further. So far, neither Hezbollah in Lebanon nor Pro-Iranian militias in Iraq have joined the fray.
Lebanese Prime Minister Nawaf Salam sent a warning message to Hezbollah not to drag the country into, quote, “adventures that threaten its security and unity.”