Features
Famed biographer Walter Isaacson’s latest book examines how “Crispr” tecnnology developed and how it’s changing our world
By MARTIN ZEILIG During the recent rebroadcast of an interview on CBC Radio’s science show, Quirks & Quarks, Dr. Jennifer Doudna told how it “was a real shock” when she received an early morning telephone call notifying her of having been co-awarded the 2020 Nobel Prize in Chemistry.
She’s a humble person. But, she shouldn’t have been so surprised.
Doudna, a professor of molecular and cell biology at University of California, Berkeley, and her collaborator, a French professor and researcher in microbiology, genetics, and biochemistry at the Max Planck Institute in Berlin, Germany, were awarded the prize for the development of the CRISPR-Cas9 genome editing technique.
This meticulously researched book by author Walter Isaacson takes a reader into the quest by Doudna and Charpentier that eventually led to their breakthrough discovery. We see Doudna as a liberal minded and generous person, as well as a brilliant and driven research scientist.
Walter Isaacson, a professor of history at Tulane University, has been CEO of the Aspen Institute, chair of CNN, and an editor at Time Magazine. He is the author of “Leonardo da Vinci”, “The Innovators”, “Steve Jobs”, “Einstein: His Life and Universe”, “Benjamin Franklin: An American Life”, and “Kissinger: A Biography”, also the coauthor of “The Wise Men: Six Friends and the World They Made”.
The essence of CRISPR (an acronym for clustered regularly interspaced short palindromic repeats) is simple: It’s a way of finding a specific bit of DNA inside a cell.
“CRISPR technology also has the potential to transform medicine, enabling us to not only treat but also prevent many diseases. We may even decide to use it to change the genomes of our children. An attempt to do this in China has been condemned as premature and unethical, but some think it could benefit children in the future, notes online information. After that, the next step in CRISPR gene editing is usually to alter that piece of DNA. However, CRISPR has also been adapted to do other things too, such as turning genes on or off without altering their sequence.
“There were ways to edit the genomes of some plants and animals before the CRISPR method was unveiled in 2012 but it took years and cost hundreds of thousands of dollars,” says the science site.
“CRISPR has made it cheap and easy.
“CRISPR is already widely used for scientific research, and in the not too distant future many of the plants and animals in our farms, gardens or homes may have been altered with CRISPR. In fact, some people already are eating CRISPRed food.
“CRISPR is being used for all kinds of other purposes too, from fingerprinting cells and logging what happens inside them to directing evolution and treating gene drives.
“The key to CRISPR is the many flavours of “Cas” proteins found in bacteria, where they help defend against viruses. The Cas9 protein is the most widely used by scientists. This protein can easily be programmed to find and bind to almost any desired target sequence, simply by giving it a piece of RNA to guide it in its search.”
Isaacson describes how a young Doudna came home one day from grade school to find that her father had left a paperback issue of the book, “The Double Helix”, by James Watson, on her bed. That classic and compelling story about Watson and his collaborator Frances Crick’s (1916-2004) race to discover the structure of DNA delighted Doudna.
Years later, Watson praised Doudna for her role in, as the author writes, “the most important biological advance” since his codiscovery of the structure of DNA.
There are many other prominent and not so well known names, at least to the non-science community, referenced in this superb story.
“The inner workings of molecules may remain, for most people, as mysterious as those of microchips, but at least all of us will be a bit more aware of the beauty and power of both,” the author writes.
“By honoring CRISPR, a virus-fighting system found in nature, in the midst of a virus pandemic, the Nobel committee reminded us how curiosity-driven basic research can end up having very practical applications. CRISPR and COVID are speeding our entry into a life-science era. Molecules are becoming the new microchips.”
This book helps us to understand that brave new world.
“The Code Breaker: Jennifer Doudna, Gene Editing, and the Future of the Human Race”
by Walter Isaacson
(Simon & Schuster 536 pg. $40.00)
Features
Musings from Dizengoff Street – by Bruce Brown
(August 8, 2026)
Outside Basimta Café in Central Jerusalem. Love the red shirt against a tiny sea of black. Not sure I am shrugging because of the ultra-orthodox uproar over a Jerusalem café operating on Shabbat or the lack of an ultra-orthodox uproar over a Jerusalem café operating on Shabbat. For the last six weeks Israeli headlines shouted about the cafe chaos. With the ultra-religious blocking entrances and storming the café. While shouting ‘Shabbos! Shabbos!’ Upsetting the secular amongst us just wanting to enjoy our Saturday iced matchas. So the wife and I thought we would check it out. And. Yes. Buy something to support the business. Uproar. Not. Blocked entrances. Not. Storming the café. Not. Albeit there were police barriers separating the devout protesters from the coffee drinkers. The protesters being just a few dozen black clad, pious Jews. Mostly teenagers. And yes. Shouting ‘Shabbos! Shabbos!’ Certainly underwhelming in its reported mayhem. Reminds me of the famous saying misattributed to Mark Twain – “If you don’t read the newspaper, you’re uninformed. If you do, you’re misinformed.” But I did enjoy my iced matcha.
(August 6, 2026)
Here we go again. Another round of forever negotiations. As someone who negotiates for a living. The way things are going in the straits. If I had to recommend a book on the subject to a new hire. Between The Art of the Deal, A Presidential Edition by Donald J. Trump or The Real Art of the Deal by the Mullahs of Iran with a special forward by the IRGC. Well. I would choose the latter.
(August 3)
Bravo Yoav Segalovitz, Liberal Yesh Atid MK and Monsour Abbas, United Arab Ra’am MK and party head. For breaking a glass ceiling where a Jewish lawmaker joins an Arab political party. No less a political earthquake in my little shtetl. Which can significantly impact coalition block arithmetic and posturing and strategy in the upcoming elections. Now Ra’am can be considered a legitimate ‘Zionist’ partner when forming coalition blocks and potentially pushing the ‘center left/right’ party over the 60 seat majority threshold. In our crazy parliamentary democracy defined by a multi-party (about fourteen!!), proportional representation system. To paraphrase Winston Churchill, Israel’s proportional representation model of governance is the best parliamentary democracy system except for all other forms of working democracies. Stay tuned for more amateurish political musings as we move towards Israel’s 26th national election – five of them held since 2019.
(August 1)
Although both sides say they are open to diplomacy. Neither really trusts the other. And American military action, or its threat, continues. I read headlines in the middle of the night -it’s a nervous habit lately– that the Dynamic Duo of Trump and Netanyahu may again strike in unison. Possibly this weekend. Yikes! Prompting me, at 2:30 AM, to dash around the house stocking my safe room. Bottled water. Canned food. Medicines. Documents. The beat goes on….
If it’s crazy here. It’s insane in Italy. With a recent online ‘Jew Hunt’ in the Milan area. Before being removed, the digital forms urged reportings of Israelis and Italian Jews staying in local hotels. The infamous Global Sumud Movement -yes, the one coordinating ‘peace and humanitarian’ flotillas to Gaza- was somehow connected. Although they deny involvement?! This deranged decree was looking to identify Zionist tourism and Zionist neo-colonization in Italy. I’ll stick with stocking the saferoom.
Then there’s New York Mayor Mamdani, a Global Sumud Movement supporter, threatening to arrest Prime Minister Netanyahu if he comes to New York. But since discovered he has no legal right for such a grandstanding, antisemitic, anti-Israel, anti-Western, anti-democratic antic. Maybe Mandami should be arrested! Or at least impeached. For being a grandstanding, antisemitic, anti-Israel, anti-Western, anti-democratic mayor.
Here’s a post Bruce sent us Friday, July 31:
WARTIME MUSINGS
Should credible threats against FLOTUS and ‘FSOTUS’ (first son..) not be justification to attack first.
As for yesterday’s summit. Netanyahu really can’t win. Explainer. If Trump now attacks without victory its ’cause of Netanyahu. If Trump now attacks with victory its ’cause of Trump. And, in Israel, if Trump doesn’t attack -victory or not- Netanyahu failed in his eighth meeting with Trump. And if Trump does attack -victory or not- half the country will vilify Bibi anyway. Missing a permutation?
Ya. I know. Kinda’ need a definition of victory for that musing to work.
And here in my little shtetle. We go to sleep unsure if there will be a code red in the middle of the night. And if not. We wake up thinking it will be tonight. How do you define stress?
Seemed like an appropriate way to end this musing.
Bruce Brown is a former Winnipegger who made aliyah to Israel over 35 years ago. Bruce first began writing for us – in his own inimitable style, in 2012, during what was known as “Operation Pillar of Defense.” His occasional musings on aspects of life in Israel that were far from what you’d typically read in other reports from Israel were hugely popular – both in the print Jewish Post & News and on this website.
We’re now glad to report that Bruce is back writing for us – this time on a regular basis. We will post Bruce’s reports as they arrive – with the date of each post at the beginning of that post.
Here’s some information about Bruce – and awards he’s received for his writing:
Bruce Brown. Canadian born. Now living in Israel (for a long time). Bruce works in Israel’s hi-tech sector by day and, in spurts, is a somewhat inspired writer by night. He received the American Jewish Press Association’s award for writing excellence in 2019 and 2025. And wrote the 1998 satire, “An Israeli is….” Bruce’s musings are political, social, economic and personal. With lots of biting, contrarian, sardonic and irreverent insight.
Features
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Features
Israel pavilion ambassadors – then and now
By BERNIE BELLAN Given that Folklorama is on again and the Israel pavilion – Shalom Square, is in full swing, I thought it timely to resurrect an article I first posted to this website in August 2023.
But before reading that article, I wanted you to see who this year’s ambassadors are for Shalom Square:
It was back in 2023, however, that I set out to answer a question that I had asked our readers to help answer: Where was the very first Israel pavilion located? Some readers had thought it was the Golden Age Club, which used to be located on Pritchard and Salter. But others weren’t so sure. Here then is what I wrote back in August 2023 – when, with the help of a librarian at the Winnipeg Public Library, I was able to solve the riddle of where the first Israel pavilion was located:
It was earlier in August 2023 that I had raised a number of questions about the history of the Israel pavilion at Folklorama.
Among those questions were: Where was the first Israel pavilion located and when did the Israel pavilion actually become a permanent fixture in the YMHA on Hargrave (before moving to its current home in the Asper Campus)?
As part of my search for answers to those questions I turned to David Cohen, who had long been the coordinator of the Israel pavilion when it was located on Hargrave, but who didn’t step into that role until 1975.
David thought that the Israel pavilion hadn’t moved to Hargrave until 1974, but he wasn’t sure where the first Israel pavilion had been located.
I tried to find information using the Winnipeg Public Library online digital archive. In case you didn’t know, anyone with a library card can access the library’s online archive. You can also have access to newspaperarchive.com through the library’s digital archive. Newspaperarchive.com is an invaluable reference tool for journalists especially – or anyone wanting to access old newspaper archives, for that matter, but ordinarily you would need a subscription to newspaperarchive.com in order to use it. For some reason, however, the search function in the Winnipeg Public Library’s digital search engine didn’t produce results when I entered the word “Folklorama.”
As a result I called the Winnipeg Public Library for assistance and received great help from someone by the name of Louis-Phillipe. After taking my information, Louis-Phillipe phoned me to say that he had found out that the library had compiled a file of press clippings related to Folklorama going back to the very first year, 1970.
Further, Louis-Phillipe said, he had found a list of the 22 pavilions in that first year of Folklorama, along with where they were located. It turns out that the Israel pavilion was actually located in two different venues that first year: the Rosh Pina and the Shaarey Zedek.
The next day I also heard from reader Phyllis Dana, who confirmed that the Israel Pavilion had been in both synagogues. Phyllis also remembered that the only food served that first year was honey cake.
But the pièce de resistance came when I heard from reader Marilyn Breitman (née Stitz), who now lives in Calgary, when she phoned me on Monday, August 21 (which is when she received the August 16 issue of the paper with my story about Folklorama).
Marilyn told me that, not only did she remember that the first Israel pavilion alternated between the Rosh Pina and the Shaarey Zedek, she had actually been the female representative of the Israel pavilion that first year. Her title, Marilyn said, was simply “Jewish.”
But, as you might also recall, the entire confusion over where the first Israel pavilion was located began with an email I had received from Roz Greenfeld, who had written to correct my mistake when I had written in the August 2 issue that the Israel pavilion had been located in the YMHA from the very beginning.
Roz pointed out that, in 1971, the second year of Folklorama, the Israel pavilion was located in “Council House” or, as it was better known, “The Golden Age Club,” on Pritchard and Salter. How did she remember that? Roz was the female representative of the pavilion that year. Her title, as I found out was “Miss Judea,” she said.
So, if the Israel pavilion was located at both the Rosh Pina and Shaarey Zedek in that first year of Folkorama, and in the Golden Age Club that second year, where was it after that?
It was left to Jewish Heritage Centre of Western Canada archivist Andrew Morrison to come up with the answer to that question. Andrew informed me that the Israel pavilion did indeed move to the YMHA in 1972 and remained there for the next 25 years, until it moved to the Asper Campus in 1997.
There was a further footnote to the story, which is when I decided to try my luck with the Winnipeg Public Library’s online archive one more time. This time, rather than searching for “Folklorama,” I tried searching for old copies of both the Free Press and the Tribune from August 1970. I did manage to get results for the Tribune and when I entered a specific search within the Tribune I found a picture of all the famale representatives of pavilions – in bathing suits.
It turned out – and this was corroborated by both Marilyn Breitman and Roz Greenfeld, the female representatives had to parade in unison – in bathing suits, as part of Folklorama festivities. Each year, as well, a queen of Folklorama was chosen. Neither Marilyn nor Roz was made queen, both of them told me, although Roz was voted “Miss Congeniality.”
In addition to finding out about the early days of the Israel pavilion, I also learned that the Chai dancers were not regular performers at the Israel pavilion in those early years – as they eventually did become. Chai performers would dance only one night in those first years, with other entertainment the other nights.
I did enlist Andrew Morrison’s help once again and did find that Chai performed only one evening during the first few years of Folklorama – from 1970 to 1976. In 1977 Chai began performing every night of Folklorama, but there were other performers on hand as well, including Jerry Maslowsky and Rabbi Yosel Rosenzweig. In 1978 the Chai Folk Ensemble was the featured entertainment every evening; however, a notice that appeared in our paper did say that whistler Harvey Pollock would “be on hand” to entertain – whatever that meant.
While some may wonder of what earth shaking importance all this is, I ask: Isn’t it fun to look back in time – for just a little while, instead of worrying about more immediate problems, such as global warming, inflation, terrorist attacks in Israel, and whether Donald Trump will be president while he’s in jail?
