Features
Famed biographer Walter Isaacson’s latest book examines how “Crispr” tecnnology developed and how it’s changing our world

By MARTIN ZEILIG During the recent rebroadcast of an interview on CBC Radio’s science show, Quirks & Quarks, Dr. Jennifer Doudna told how it “was a real shock” when she received an early morning telephone call notifying her of having been co-awarded the 2020 Nobel Prize in Chemistry.
She’s a humble person. But, she shouldn’t have been so surprised.
Doudna, a professor of molecular and cell biology at University of California, Berkeley, and her collaborator, a French professor and researcher in microbiology, genetics, and biochemistry at the Max Planck Institute in Berlin, Germany, were awarded the prize for the development of the CRISPR-Cas9 genome editing technique.
This meticulously researched book by author Walter Isaacson takes a reader into the quest by Doudna and Charpentier that eventually led to their breakthrough discovery. We see Doudna as a liberal minded and generous person, as well as a brilliant and driven research scientist.
Walter Isaacson, a professor of history at Tulane University, has been CEO of the Aspen Institute, chair of CNN, and an editor at Time Magazine. He is the author of “Leonardo da Vinci”, “The Innovators”, “Steve Jobs”, “Einstein: His Life and Universe”, “Benjamin Franklin: An American Life”, and “Kissinger: A Biography”, also the coauthor of “The Wise Men: Six Friends and the World They Made”.
The essence of CRISPR (an acronym for clustered regularly interspaced short palindromic repeats) is simple: It’s a way of finding a specific bit of DNA inside a cell.
“CRISPR technology also has the potential to transform medicine, enabling us to not only treat but also prevent many diseases. We may even decide to use it to change the genomes of our children. An attempt to do this in China has been condemned as premature and unethical, but some think it could benefit children in the future, notes online information. After that, the next step in CRISPR gene editing is usually to alter that piece of DNA. However, CRISPR has also been adapted to do other things too, such as turning genes on or off without altering their sequence.
“There were ways to edit the genomes of some plants and animals before the CRISPR method was unveiled in 2012 but it took years and cost hundreds of thousands of dollars,” says the science site.
“CRISPR has made it cheap and easy.
“CRISPR is already widely used for scientific research, and in the not too distant future many of the plants and animals in our farms, gardens or homes may have been altered with CRISPR. In fact, some people already are eating CRISPRed food.
“CRISPR is being used for all kinds of other purposes too, from fingerprinting cells and logging what happens inside them to directing evolution and treating gene drives.
“The key to CRISPR is the many flavours of “Cas” proteins found in bacteria, where they help defend against viruses. The Cas9 protein is the most widely used by scientists. This protein can easily be programmed to find and bind to almost any desired target sequence, simply by giving it a piece of RNA to guide it in its search.”
Isaacson describes how a young Doudna came home one day from grade school to find that her father had left a paperback issue of the book, “The Double Helix”, by James Watson, on her bed. That classic and compelling story about Watson and his collaborator Frances Crick’s (1916-2004) race to discover the structure of DNA delighted Doudna.
Years later, Watson praised Doudna for her role in, as the author writes, “the most important biological advance” since his codiscovery of the structure of DNA.
There are many other prominent and not so well known names, at least to the non-science community, referenced in this superb story.
“The inner workings of molecules may remain, for most people, as mysterious as those of microchips, but at least all of us will be a bit more aware of the beauty and power of both,” the author writes.
“By honoring CRISPR, a virus-fighting system found in nature, in the midst of a virus pandemic, the Nobel committee reminded us how curiosity-driven basic research can end up having very practical applications. CRISPR and COVID are speeding our entry into a life-science era. Molecules are becoming the new microchips.”
This book helps us to understand that brave new world.
“The Code Breaker: Jennifer Doudna, Gene Editing, and the Future of the Human Race”
by Walter Isaacson
(Simon & Schuster 536 pg. $40.00)
Features
How DIY Auto Repairs Can Help You Cut Costs—Safely

Regular maintenance and minor repairs are the greatest approach for many car drivers to save money without sacrificing dependability. DIY repairs can save you a lot of money over the life of your car since most of the expense is in the labour. DIY helps you learn how things work and notice tiny issues before they become costly ones. Every work requires planning, patience, and safety.
Test Your Talents with Safe Limits
DIY solutions succeed when one is honest about their talents. Wiper blades, air filters, and occupant filters are beginner-friendly. With the correct equipment, intermediate owners can replace brake pads, spark plugs, coolant, and brake fluid. Pressurized fuel, high-voltage hybrids, airbags, and timing components are risky. Only professionals should manage them. Limitations protect you and your car. Drivers trust sources like Parts Avenue to find, install, and schedule manufacturer-approved work.
Set Up a Reliable Workspace and Tools
Good tools pay for themselves quickly. Ratchets, torque wrenches, combination wrenches, heavy jack stands, and wheel chocks are essential. It is advisable to engage specialists for specific tasks. A clean, flat, well-lit, and open space is essential. Please take your time. While working, keep a charged phone nearby to read repair instructions or write torque patterns.
Find the Problem before Replacing the Parts
It may cost more to replace something without diagnosing it. Instead of ideas, start with symptoms. OBD-II readers detect leaks, sounds, and DTCs. Simple tests like voltage, smoke indicating vacuum leaks, pad thickness, and rotor runout might reveal failure. A good analysis saves components, protects surrounding parts, and fosters future trust.
Maintenance That Pays off is Most Crucial
Jobs compensate for time and tools differently. Prioritize returns and maintenance. Change the oil and filter, rotate the tires, evaluate the air pressure, replace low brake fluid, clean the coolant with the right chemicals, and replace belts and filters before they fail. These items extend automotive life, stabilize fuel efficiency, and reduce roadside towing issues that can take months to resolve.
Do as Instructed, Utilize Quality Parts, and Follow Torque Requirements
Understand the service. Set the jacking points, tighten the screws in the appropriate order, and use threadlocker or anti-seize as suggested by the maker. Rotor wear can cause leaks, distortions, or broken threads. Choose components that meet or exceed OEM requirements and fit your car’s VIN, engine code, and manufacturing date. Cheap parts that break easily cost extra.
Test, Record, and Discard Carefully
Safely test the system before patching. Check under the car for drops, bleed the brakes again, and check fluid levels after a short drive. Note torques, parts, miles, and repair date. Photo and document storage for car sales. Properly dispose of oil, filters, coolant, and brake fluid. Controlling hazards protects your community and workplace.
Know When to Seek Professional Help
Self-employed individuals recognize their constraints. If a task is challenging, requires special instruments, or involves safety, consult an expert. Collaboration makes cars safer, cheaper, and more efficient. Selecting, planning, and implementing processes properly improves performance, lowers costs, and ensures safety.
Features
What It Means for Ontario to Be the Most Open iGaming Market in Canada

Ontario is the most open commercial iGaming market in Canada, having been the first province to open up to commercial actors in the online casino and betting space since 2022.
Since gambling laws in Canada are managed on a provincial level, each province has its own legislation.
Before April 4th, 2022, Ontario was similar to any other Canadian province in the iGaming space. The only gaming site regulated in the province was run by government-owned Ontario Lottery and Gaming Corporation, also known as OLG. However, when the market opened up, numerous high-quality gambling companies established themselves in the province, quickly generating substantial revenue. As the largest online gambling market in Canada, it’s now, three years later, also one of the biggest in North America.
The fully regulated commercial market is run under iGaming Ontario and the Alcohol and Gaming Commission of Ontario. These licensed casinos and online sportsbooks are thus fully legal and safe for players to play at, while at the same time, the open market allows companies to compete and offer different products and platforms as long as they all fit within the requirements set up by the state of Ontario.
This means that Ontarians have a wide choice of licensed sites, whether they’re interested in sports betting, live dealer games, or slots – all with strict consumer-protection rules that keep them safe while exploring the many options. (Source: https://esportsinsider.com/ca/gambling/online-casinos-canada)
There are many benefits to online gaming, especially in a country that’s as sparsely populated as Canada, leaving physical venues often few and far between for those living outside the biggest cities.
Even before Ontario launched its own gambling sites, online gambling had been common among Ontarians. Regulating the market and offering alternatives regulated by the province has often added safer and more controlled options.
Since 85% of Ontarians now play at regulated sites, the initiative of opening up the market seems a clear win in more than one way.
Despite the huge success of the Ontario market, most provinces in Canada haven’t changed much in the iGaming sector in the past few years. Some provinces keep Crown-run monopolies, while others limit activity to a single government-run platform. This often leads Canadians to seek offshore alternatives instead, since the options are so few in their own province.
But 2025 marks an important change. The provinces seem to have noticed that Ontario picked a winning strategy, and Alberta has clearly been taking notes.
While the province of Alberta has previously opted for controlled gambling through one government website, the province is now opening up the commercial online gambling market. The Alberta iGaming Corporation will be in charge of licensing and inspecting actors that operate in the province. This will mean many more options for players, coupled with consumer protection and a high level of safety.
Meanwhile, the Ontario iGaming market continues to prosper, grow, and develop. Now that a second province is following in its footsteps, it seems more likely that other provinces will also start following the trend.
Features
I know exactly why leftists aren’t celebrating this ceasefire

Relief that the fighting may be at an end is one thing. Joy — after all this suffering — is another
This story was originally published in the Forward. Click here to get the Forward’s free email newsletters delivered to your inbox.
“We can’t hear you, Zohran,” read one New York Post headline this week: “Pro-Hamas crowd goes quiet on Trump’s Gaza peace deal.”
“It seems awfully curious that the people who have made Gazans a central political cause do not seem at all relieved that there’s at least a temporary cessation of violence … Why aren’t there widespread celebrations across Western cities and college campuses today?” the article asked.
The Post wasn’t alone in voicing that question. A spokesperson for the Republican Jewish Coalition posted on X that “The silence from the ‘ceasefire now’ crowd is shameful and deafening.” Others went so far as to imply that the protesters had been lying and never actually wanted a ceasefire — because what they really wanted wasn’t freedom and security for Palestinians, but the ability to blame Israel. If pro-Palestinian voices had really wanted a ceasefire, the thinking went, they would be celebrating.
I read these various posts and articles and thought of Rania Abu Anza.
I have thought of her every day since I first read her story in early March 2024. Anza spent a decade trying to have a child through in vitro fertilization. When her twins, a boy and a girl, were five months old, an Israeli strike killed them. It also killed her husband and 11 other members of her family.
A year and a half later, a ceasefire cannot bring her children, her husband, or her 11 family members back. They were killed. They will stay dead. What is there to celebrate?
This does not mean that the ceasefire is not welcome, or that it is not a relief. On the contrary: It is both. Of course it’s a relief that the families of hostages don’t need to live one more day in torment and anguish. Of course it’s a relief that more bombs will not fall on Gaza.
But celebration implies, to me anyway, that this is a positive without caveats. And in this situation, there are so many caveats.
The families of the surviving hostages will still have spent years apart from their loved ones, in no small part because their own government did not treat the hostages’ return as the single highest priority. The families of those hostages who were killed in the war will never again sit down to dinner with their loved ones, who could have been saved. And it is difficult to fathom what’s been taken from the hostages themselves: time spent out exploring the world, or with family and friends, or at home doing nothing much at all but sitting safely in quiet contemplation.
And a ceasefire alone will not heal Israeli society, or return trust to the people in their government. It will not fix some of the deep societal problems this war uncovered. A Chatham House report this August found that: “Israeli television ignores the suffering of Palestinians in Gaza, while the rhetoric is often aggressive. Critical voices, from inside Israel or abroad, are attacked or silenced.” If the country is ever going to find its way back from Oct. 7 and this war, a ceasefire is a necessary precondition, but not a route in and of itself.
In Gaza, Palestinian health authorities have said that about 67,000 people — not distinguishing between combatants and civilians — have been killed by Israel’s campaign in response to Oct. 7. A full third of those killed were under the age of 18. The ceasefire cannot bring those children back to life.
It cannot turn back time and make it such that Israel admitted more than minimal aid to the embattled strip. It will not undo the damage that has been done to the people of Gaza who were denied enough to eat and drink and proper medical care. It will not give children back their parents, or parents back their children. It will not heal the disabled, or make it so that they were never wounded.
It will not change that all of this happened with the backing of the United States government. (This is to say nothing of the West Bank, which has seen a dramatic expansion of Israeli settlements and escalation of settler violence over the course of the war). And as American Jewish groups put out statements cheering the ceasefire, we should also remember that it does not reverse the reality that too many American Jews were cheerleaders for all this death.
Protesters calling for a ceasefire have regularly been denounced as hateful toward Jews or callous toward the plight of Israelis; American Jews who called for one were called somehow un-Jewish. (Yes, some pro-Palestinian protesters also shared hate toward Jews; the much greater majority did not.) The charge of antisemitism — toward those calling for a ceasefire, those calling for a free Palestine, and those who called attention to Israel’s abuses during this war — was used to silence criticism of Israel and of U.S. foreign policy. Some American Jews went so far as to call for the deportation of students protesting the war.
A ceasefire doesn’t change any of that. It can’t.
I have hopes for this ceasefire. At best, it will allow people — Israelis and Palestinians and, yes, diaspora Jews — to chart a new, better course going forward. But it almost certainly will not do that if we delude ourselves into thinking of this as a victory or a kind of tabula rasa, as though the lives lost and hate spewed are all behind us, forgotten, atoned for. The last two years will never not have happened. What happens next depends on all of us fully appreciating that.
This story was originally published on the Forward.