Features
Famed biographer Walter Isaacson’s latest book examines how “Crispr” tecnnology developed and how it’s changing our world
By MARTIN ZEILIG During the recent rebroadcast of an interview on CBC Radio’s science show, Quirks & Quarks, Dr. Jennifer Doudna told how it “was a real shock” when she received an early morning telephone call notifying her of having been co-awarded the 2020 Nobel Prize in Chemistry.
She’s a humble person. But, she shouldn’t have been so surprised.
Doudna, a professor of molecular and cell biology at University of California, Berkeley, and her collaborator, a French professor and researcher in microbiology, genetics, and biochemistry at the Max Planck Institute in Berlin, Germany, were awarded the prize for the development of the CRISPR-Cas9 genome editing technique.
This meticulously researched book by author Walter Isaacson takes a reader into the quest by Doudna and Charpentier that eventually led to their breakthrough discovery. We see Doudna as a liberal minded and generous person, as well as a brilliant and driven research scientist.
Walter Isaacson, a professor of history at Tulane University, has been CEO of the Aspen Institute, chair of CNN, and an editor at Time Magazine. He is the author of “Leonardo da Vinci”, “The Innovators”, “Steve Jobs”, “Einstein: His Life and Universe”, “Benjamin Franklin: An American Life”, and “Kissinger: A Biography”, also the coauthor of “The Wise Men: Six Friends and the World They Made”.
The essence of CRISPR (an acronym for clustered regularly interspaced short palindromic repeats) is simple: It’s a way of finding a specific bit of DNA inside a cell.
“CRISPR technology also has the potential to transform medicine, enabling us to not only treat but also prevent many diseases. We may even decide to use it to change the genomes of our children. An attempt to do this in China has been condemned as premature and unethical, but some think it could benefit children in the future, notes online information. After that, the next step in CRISPR gene editing is usually to alter that piece of DNA. However, CRISPR has also been adapted to do other things too, such as turning genes on or off without altering their sequence.
“There were ways to edit the genomes of some plants and animals before the CRISPR method was unveiled in 2012 but it took years and cost hundreds of thousands of dollars,” says the science site.
“CRISPR has made it cheap and easy.
“CRISPR is already widely used for scientific research, and in the not too distant future many of the plants and animals in our farms, gardens or homes may have been altered with CRISPR. In fact, some people already are eating CRISPRed food.
“CRISPR is being used for all kinds of other purposes too, from fingerprinting cells and logging what happens inside them to directing evolution and treating gene drives.
“The key to CRISPR is the many flavours of “Cas” proteins found in bacteria, where they help defend against viruses. The Cas9 protein is the most widely used by scientists. This protein can easily be programmed to find and bind to almost any desired target sequence, simply by giving it a piece of RNA to guide it in its search.”
Isaacson describes how a young Doudna came home one day from grade school to find that her father had left a paperback issue of the book, “The Double Helix”, by James Watson, on her bed. That classic and compelling story about Watson and his collaborator Frances Crick’s (1916-2004) race to discover the structure of DNA delighted Doudna.
Years later, Watson praised Doudna for her role in, as the author writes, “the most important biological advance” since his codiscovery of the structure of DNA.
There are many other prominent and not so well known names, at least to the non-science community, referenced in this superb story.
“The inner workings of molecules may remain, for most people, as mysterious as those of microchips, but at least all of us will be a bit more aware of the beauty and power of both,” the author writes.
“By honoring CRISPR, a virus-fighting system found in nature, in the midst of a virus pandemic, the Nobel committee reminded us how curiosity-driven basic research can end up having very practical applications. CRISPR and COVID are speeding our entry into a life-science era. Molecules are becoming the new microchips.”
This book helps us to understand that brave new world.
“The Code Breaker: Jennifer Doudna, Gene Editing, and the Future of the Human Race”
by Walter Isaacson
(Simon & Schuster 536 pg. $40.00)
Features
The Popularity of Simpler Slot Games in 2026: Review From Casino Online CrazyTower Experts
Online casinos now fill their libraries with numerous video slots that have dozens of functions, long bonus rounds, complex mechanics, and so on. Interestingly, despite this huge range of modern options, many Canadian visitors at sites like Casino Online CrazyTower here https://crazytower.com/ca/ no longer want complicated gameplay that requires constant attention and long explanations.
Simpler slots now attract a wider audience because they save time and create faster sessions. So, let’s figure out why this change happened and reasons for the popularity of simpler machines.
Why Many Players Are Returning to Basic Gameplay
Modern websites like Casino Online CrazyTower pushed complex video slots for years, but many people now prefer classic formats again. Simple gameplay has fewer interruptions and is simpler in terms of budgeting, which is important when you gamble for fun.
These are a few potential reasons explain why simpler slots became popular again in 2026:
- Faster rounds. Symbols appear quickly, and rounds continue without long animations or extended bonus sequences.
- Easier controls. Most classic slots have simple menus and familiar layouts that don’t confuse new visitors.
- Smaller feature lists. Simple slots usually have standard wilds, scatters, and multipliers instead of dozens of random mechanics.
- Better session flow. People spend more time on gameplay instead of reading explanations about symbols and special functions.
- Lower visual pressure. Simpler slots use calmer designs and shorter effects that don’t overload attention.
Classic gameplay also suits mobile devices better because shorter rounds work well on smaller screens. Plus, many visitors now prefer games that start instantly and explain their mechanics within seconds.
Features That Make Simpler Slots Appealing
Simple machines at Casino Online CrazyTower and similar websites continue to attract attention because they have a high gameplay speed. Many classic titles also replicate older casino machines that people already know from physical casinos.
However, these aren’t the only factors that attract gamblers. So, check out this list:
- Short bonus rounds. Free spins and multipliers finish quickly instead of interrupting gameplay for several minutes.
- Common and standard paylines. Traditional layouts help people understand payouts without long explanations.
- Faster loading times. Simpler graphics reduce waiting time on phones, tablets, and older computers.
- Stable gameplay pace. Long cutscenes and constant pop-up notifications don’t interrupt the session.
- Traditional themes. Fruit symbols, bars, sevens, and classic casino designs still attract large audiences.
- Smaller menus. Important information appears immediately without complicated tabs or hidden sections.
Modern video slots often contain too many mechanics in a single game. Developers now combine expanding reels, random modifiers, mission systems, tournaments, and multiple bonus levels in one title. Many visitors lose interest because gameplay turns repetitive and overloaded with constant interruptions.
Compare this to a session when you get results immediately and aren’t interrupted. These still have free spins and even mini risk games, but not as loaded as innovative titles.
Conclusion
Simple slots usually create better replay value because people understand the mechanics immediately. Common and standard gameplay doesn’t cause frustration and allows faster decisions during casino sessions.
Many classic slots also function better during short breaks because rounds finish quickly without long bonus interruptions. That’s why simpler slots became popular again at many casinos, including Casino Online CrazyTower and such.
Features
Football: Which team from Israel could we see in the European Cup next year?
With Europe’s club competitions heading into another summer of drama, Israeli football is on the table. The domestic season is done, trophies picked up and now a new batch of clubs can now try their luck against continental competition.
What are the prospects of these teams in Europe next year and who are they? It all starts with Hapoel Be’er Sheva’s title, Maccabi Tel Aviv’s cup win and the competition of the best Israel football teams against each other, as fans look to Champions League on Wincomparator to see what teams are in contention.
How Israel’s clubs qualify for Europe: The 2026-2027 spots
Qualification to join the European elite hinges on the 2025-26 Israeli Premier League table and the Israel State Cup. Israel will have one Champions League spot, one Europa League spot, and two Europa Conference League spots in 2026-27.
That means the league winner gets into the Champions League, the State Cup winner goes on to Europa League qualifying. The next eligible league’s finishers take the Conference League slots. It’s a good model as it provides a tangible reward for consistency at home, while at the same time demonstrating the importance of each playoff game. A top three finish can help a club’s summer, bring in better players and provide fans with a European tour before the next season’s start.
The Champion’s quest: Israel’s hope for the Champions League
Meet the 2025-26 Premier League winner: Hapoel Be’er Sheva
Hapoel Be’er Sheva have qualified for Israel’s Champions League after their Israeli Premier League title win with 79 points scored in 36 games. Ran Kozuch’s side closed the gap on the three-point lead but also showed significant strength in the attacking phase to secure a win in a crucial championship round with Beitar Jerusalem.
Their challenge also comes as their reward. Hapoel Be’er Sheva are only expected to begin in the second round of the Champions League, not the league round. To get to the main competition they need to pass through the first round of the other national champions in two-legged ties, and their seeding, fitness and sharpness in early-season competition could be a game breaker.
While the club has experience in Europe and a rabid Turner Stadium following, the path is tough. It takes one bad outing to wipe out a year’s worth of work. However, as long as the bedrock remains the same and they are able to put some depth into the team, the champions have the balance to fight.
Battling in the Conference League: Israel’s other European contenders
The State Cup winner and league runners-up
Maccabi Tel Aviv go to Europe after the Israel State Cup final 2-1 win against Hapoel Be’er Sheva at Teddy Stadium, Jerusalem. That win denied Be’er Sheva a home double, and also meant that Maccabi got into the Europa League qualifying, where they were put in the second qualifying round thanks to access-list rebalancing.
The Conference League qualifiers are Beitar Jerusalem who finished second in the league with 76 points, and Hapoel Tel Aviv who finished fourth with 60 points. The importance of Maccabi Tel Aviv’s cup victory lies in the fact that it unlocked the rest of the way in the league. Beitar’s season was particularly impressive as they scored 78 goals and lost just four matches. On the other hand, Hapoel Tel Aviv managed to remain above Maccabi Haifa in the final table standing, earning them a well-deserved European berth.
The Europa Conference League is no consolation prize for these clubs. It’s a realistic platform. Although there are still a few hurdles to navigate, Israeli sides consider this competition to be the most realistic one for European football in the autumn.
A look at past successes and future hopes
This group has reason for belief, based on recent history. Israeli teams can make significant nights in Europe, and Maccabi Haifa did just that, when they made it into the Champions League group stage in 2022-23, and then impressively took out Juventus 2-0 in Haifa.
There is significant monetary and sporting worth in qualification. A UEFA cup can make a difference to a club, as can better attendance, TV coverage and recruitment opportunities. The early storylines will be the draw for Hapoel Be’er Sheva in the Champions League, as well as Maccabi Tel Aviv in the Europa league and the two Conference League routes — Beitar Jerusalem and Hapoel Tel Aviv. They all have tricky paths to follow, but all four provide Israeli football with a realistic European presence next summer.
Features
At one time one entire block of McAdam Ave. was almost totally Jewish
This story originally appeared in a November 2014 issue of The Jewish Post & News:
1994 McAdam Ave. reunion (names inside story)By GERRY POSNER (This story first appeared in November 2014.)
Once upon a time when life was simpler and gentler, there was a street in the north end of Winnipeg which was like all other streets in the city except in one significant way. Everyone, but for one family, living on McAdam east of Main Street was Jewish.
