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Nonapeptide-1: Melasma Research Results

Brown macules are characterized by the emergence of hyperpigmented patches in a symmetrical pattern along the epidermal barrier following sun-exposure. The three most prevalent clinical patterns are dentofacial, malar, and mandibular melasma. While melasma’s precise etiology remains a mystery, researchers believe that environmental and genetic variables contribute to the condition’s onset. Factors in the environment include things like sun exposure, chemical interactions, estrogen-progesterone supplementation, thyroid dysfunction, hormone replacement, among others.

Fitzpatrick’s skin type IV-VI models are believed to develop melasma at a higher rate. However, the condition’s incidence has not been studied in most countries.

Nonapeptide-1 Research

From November 2015 to September 2016, the research was done at the Dermatology Department of Command Hospital in Kolkata. The researchers evaluated models of moderate to severe hypomelanosis, which is consistent with a clinical diagnosis of melasma. Malar melasma affected 19 of the 46 research models, whereas centrofacial melasma affected 27. According to Wood’s lamp examination, all research models exhibited mixed melasma.

Computer-generated software randomly assigned the participants to either the case or control groups. The pilot research had three stages.

Nonapeptide-1: Phase 1

Every night before the shutdown, research models in both the case and control groups were given a 5% tretinoin, 0.01% fluocinolone acetonide, and 4% hydroquinone concentration, and they also used a physical blocker sunscreen with an SPF of 30. This regimen lasted for the first eight weeks of presentation. This product contains avobenzone. Octocrylene and 2% weight/weight octyl methoxycinnamate, 3% by weight + oxybenzone 7.5% w/w apply 3% water-based zinc oxide solution three times daily beginning at sunrise and continuing until sunset. There were three visits during phase 1, with a four-week ± three-day delay between each. These visits were visit 1 (baseline), visit 2, and visit 3. At predetermined intervals, research models in both groups received 3 milliliters of sunscreen .

At either visit one (P=0.7223) or visit three (P=0.3863), there was hypothesized to be no statistically significant difference between the control and case groups. Therefore, the data suggests that the groups may be similar in terms of mean melanin concentration as determined by the hexameter.

Nonapeptide-1: Phase 2

After that, for 16 weeks, the subjects in the case study were given the study formulation—which included phenyl ethyl resorcinol, nonapeptide-1, aminoethyl phosphinic acid, antioxidants, and sunscreen—exposed twice a day, at 08:00 and 14:00, respectively. The subjects in the control group were given sunscreen as a control compound. There were four visits during phase 2, with a four-week ± three-day delay between each visit (visit 4, visit 5, visit 6, and visit 7).

The findings implied that while there was an increase in the case group, the difference did not appear statistically significant. Between visits 3 and 7, the case group suggested a greater decrease in mean melanin content than the control group. At the seventh visit, the average melanin content in the case group was 403.9 (±13.25), while in the control group, it was 412.12 (±30.8). There was no statistically significant difference in melanin content between the two groups (P = 0.59).

Nonapeptide-1: Phase 3

Research models in the case and control groups with melasma did not receive any compounds throughout the follow-up period. With an interval of 8 weeks ± 3 days, there was a total of 1 visit during phase 3, which was visit 8.

The presentation of melasma was discontinued after visit 7 in both the case and control groups. In the case group, 10 research models (58%) were theorized to exhibit no change or improvement in melasma severity from receiving various approaches, whereas 7 research models (42%) indicated worsening symptoms.

In the control group, four test subjects (or 35% of the total) appeared to have exhibited no improvement, and nine research models (or 65% of the total) appeared to exhibit symptoms that became worse. Nonetheless, the disparity was not statistically significant. While the control group’s mean melasma area and severity index score grew from 9 at baseline to 9.9 at visit 8, the case group’s scores decreased from 9.9 at baseline to 7.8 at visit 8.

Nonapeptide-1: Concluding Remarks

Fourteen male and forty-two female melasma research models were recruited for the research. Seventeen research models made it through the research in the case group. Lack of follow-up was the main cause of early termination. Fourteen test subjects were made through the experiment in the control group. Lack of follow-up was once again the main cause of early termination.

Scientists interested in more Nonapeptide-1 research are encouraged to visit the Biotech Peptides website for more educational and informative peptide articles.

References

[i] Balkrishnan R, McMichael AJ, Camacho FT, Saltzberg F, Housman TS, Grummer S, et al. Development and validation of a health-related quality of life instrument for women with melasma. Br J Dermatol 2003;149:572-7.

[ii] Grimes PE. Melasma. Etiologic and therapeutic considerations. Arch Dermatol 1995;131:1453-7.

[iii] Pandya AG, Guevara IL. Disorders of hyperpigmentation. Dermatol Clin 2000;18:91-8, ix.

[iv] Ting PT, Barankin B. Can you identify this condition? Melasma. Can Fam Physician 2005;51:353-5.

[v] Estrada CR, Torres BB, Alarcon HH, Arrizon VA, Sandoval ME, Lopez CG, et al. Cutaneous epidemiology in two sectors of Guerrero, Mexico. Dermatologia Rev Mex 1992;36:29-34.

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Winnipegger behind restoration of historic Jewish cemetery in Portugal

Bonnie Neil

By MYRON LOVE The Butterfly Effect is roughly the idea that, metaphorically, great trees grow from small seeds or, to be more specific, the theory that tornadoes in North America may be triggered by a butterfly in Africa – or a seagull in the Atlantic – flapping its wings multiple times.
This story is an example of the Butterfly Effect in human terms.  Roughly 40 years ago, a Winnipegger by the name of Bonnie Neil – she was known as Bonnie Griffith back then – happened to be visiting Portugal – in her role as program director of the old Hargrave YMHA’s Stay Young seniors group – and came across an abandoned Jewish cemetery in the south of the country.  She mentioned the sorry state of the cemetery to a member of the small Jewish community in Lisbon.  Now, that cemetery is a Jewish heritage site.
A social worker by training, she was hired by the Y in 1975 to work with teens. After a short time, she switched her focus to developing programming for older Jewish adults. “I founded the Stay Young Club,” recalls Neil (who isn’t Jewish).  “When I started at the Y, there were no programs for older adults.  I first proposed to Les Marks (who was then the Y’s executive director) the idea of programming for older adults and he gave me carte blanche to create programming.”
With funding from the Jewish Foundation and the Federal Government’s New Horizons program, Neil set to work. She began with a weekly gym and swim program, then added a weekly lunch, a Yiddish group, a choir and a light exercise group. Within a couple of years, the Stay Young Club was offering activities for older adults every week day.
The ambitious Neil then began going further afield.  She began organizing short trips for Stay Young members, starting with Calgary and Edmonton, subsequently to Florida and Palm Springs. Looking even further afield, she took her charges to  Israel three times –with assistance the first time from the well known Noach Witman (who operated Witman Travel in addition to hosting the Jewish Radio Hour).  Subsequent Israeli trips were organized through Beth Shore at Flair Travel.
Les was always asking me where we were going to go next,” she remembers.  “I had come across a little book listing places of Jewish interest.  I noticed that Portugal wasn’t listed.  We had been flying with CP Air -which flew to Portugal. I decided to go to Portugal to see for myself what might be of interest to Jewish travellers.
“As I knew nothing about the country, I asked a Jewish woman I met what there was in Portugal that might be of interest to Jewish travellers?  She suggested I visit the southern city of Faro where there was a Jewish cemetery.”
Now some background: It is common knowledge (I think) that all Jews (except those who were willing to convert to Christianity) were expelled from Portugal in 1496 – four years after Jews were expelled from Spain.  I hadn’t given much thought to what Jewish life in Portugal was like following the expulsion.  According to information that Neil gave me, Portugal began allowing some Jews back into the country in the early 1800s.  During World War II, the country became a haven for Jews fleeing Nazi persecution. Thousands of Jewish refugees found safety in Portugal. After the war, most left for other destinations.  The Jewish population currently is about 900 – with two-thirds living in Lisbon, the capital.
(Ed. note: Portugal has become a prime destination for Israelis seeking to obtain citizenship in a different country, although without actually leaving Israel. According to the Times of Israel, over 60,000 Israelis have been granted Portugese citizenship, although only 569 had actually moved there as of September 2023. According to the TOI article, ‘The surge of Israeli applicants began after Portugal passed its “law of return” in 2015, allowing the descendants of Portuguese Sephardic Jews who were affected by the 16th-century Inquisition to apply for nationality. The Portuguese government has announced plans to end this policy in December 2023, saying its purpose of reparation will be ‘fulfilled.’ “
It sounds quite similar to the vast number of Lebanese who hold Canadian citizenship – between 40-75,000. It seems that Portugal and Canada offer attractive alternative destinations for Israelis on the one hand, and Lebanese on the other. If either group thought their lives were truly in peril, then they would have a safe place to where they could run, but in the meantime both Israelis and Lebanese seem content to stay where they are.)
In the 15th century, Faro had been a centre of Hebrew printing.  The Jewish community began to be reconstituted in the 19th century.  The cemetery was opened in 1820.  In the 1860s, Jews from Morocco settled in the community – with some Russian and Polish Jews coming before World War I.

The Jewish cemetery in Faro, Portugal


So Neil traveled to Portugal on an exploratory visit and asked her guide to show her the cemetery. She was horrified by what she saw.
“The last Jewish resident of Faro had died a  year before,” she recalls.  “When I arrived, the gates were locked.  I could see that there was garbage and weeds everywhere. I also learned that the city was planning to tear down the cemetery to expand a sports field nearby.  I let it be known that I was planning to bring a group of Jewish tourists and I got a promise that the cemetery would be cleaned up.”
During a stopover in Lisbon, she mentioned the cemetery’s deplorable condition. Then she went home.  As it happened, the tour was cancelled due to a lack of registrants. 
She says that she never gave Portugal another thought.
In 1985 she left the Y for government employment.  “While I loved working at the Y,” she says, “I was a single mother by then with two children – and the government was offering a salary that was twice what the Y was paying.”
Recently, Neil learned what happened to the cemetery.  It seems that shortly after she alerted the Jewish community in Lisbon,   a community member by the name of Ike Bitton founded the Faro Cemetery Restoration Fund.  The result of the fundraising effort resulted not only in the cemetery’s restoration, but also the opening a small Jewish museum containing a display of furniture from Faro’s synagogues.
Neil left government in 1992 to go into private practice in the social work field.  She notes that she did some programming with seniors at the Simkin Centre. She retired in 2014.  She still supports some Jewish institutions such as the Winnipeg Jewish Theatre. 

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Famous Gambling Scandals and Controversies: Allyspin Casino Opinion

The gambling industry is full of scandals and controversies. There are various cases of fraud and manipulation schemes. That is why it is very important to pay attention to reliable gambling sites like Allyspin online casino, which follows the rules of responsible and safe gambling for its fans. Research shows that more than one trillion dollars are bet worldwide every year. That is why it is very important to be able to distinguish safe and reliable sites from fraudulent ones.
Casino Fraud and Money Laundering
Honest and secure gambling websites like Allyspin casino are careful not to fall victim to scammers. However, many sites are often targets for money laundering and fraud. Due to the large volume of transactions and cash flow, it is difficult to track all the directions of the flow of funds.
Among the largest scandals, the Crown Resorts in Australia stands out. An investigation showed that the casino was used to launder millions. Macau casino networks have also been involved in high-profile scandals. Thus, the region has faced close attention due to allegations of organized crime and laundering billions of dollars through betting. In addition, there are many money laundering cases in Las Vegas casinos.
There are many different methods of money laundering in online casinos. For example, fraudsters use chip dumping, cashing out winnings. Also, structuring is used by entering small amounts that are difficult to track over time.
Gambling Industry Reforms after Scandals
Sites like Allyspin casino do everything possible to prevent such scandals. Thus, the latest security measures and solutions are actively implemented:
Advanced fraud detection based on artificial intelligence. With the help of modern algorithms, monitoring of suspicious behavior when placing bets is simplified.
Strict identity verification protocols. Users need to confirm their identity before being able to withdraw funds.
Secure data using blockchain. Modern online casinos use cryptocurrency payments and blockchain in order to reduce the risks of unauthorized access to transactions.
Responsible gaming programs are also actively implemented. Online casinos offer the option of self-exclusion, as well as provide full support to players. All this allows you to minimize possible risks in the process of gambling and ensure the transparency of payment transactions.
The Future of Casino Security and Fraud Prevention
Large sites like Allyspin casino continue to expand, introducing enhanced security and fraud prevention tools. In the near future, such unique features will be available:
Fraud detection systems based on artificial intelligence and machine learning. Automation of processes helps to detect any fraudulent facts much faster compared to traditional methods.
Blockchain technology and cryptocurrency. Cryptocurrency payments help not only simplify payments for users, but also reduce the risks of unauthorized transactions.
Biometric and multi-factor authentication. Thus, users undergo unambiguous identification, which reduces the risk of account use by fraudsters.
Cybersecurity plays an important role in online casino gambling. Modern sites implement the latest mechanisms to combat fraud, ensure fair gaming process and fully protect honest players.

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